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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Overcoming anti-PD-1 resistance by systemic delivery of an oncolytic adenovirus that targets TGF-beta

    SBC: Multivir Inc.            Topic: 102

    Project Summary The overall goal of this proposal is to test a novel systemic Adenoviral therapy that targets transforming growth factorTGFand reverses anti PDresistance to treat advanced breast and lung cancersThis STTR grant application illustrates the synergistic relationship between DrPrem Sethinventor of a novel TGFdecoyand MultiVir Inca leader in clinical development of gene based therapeuti ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Non-invasive device to assist selecting the level-of-amputation in patients with peripheral arterial disease

    SBC: Spectral Md, Inc.            Topic: NHLBI

    AbstractThis is a Phase I SBIR proposal to develop a non contact and non invasive imaging device for assisting cliniciansin selecting the appropriate level of amputationLOAin limbs with peripheral arterial diseasePADSurgeonsprefer to salvage as much limb tissue as possible during amputation to increase patient mobility while decreasingmorbidity and mortalityHoweverclinicians must balance this pref ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Quantitative Analysis of Single Molecule Microscopy

    SBC: Astero Technologies LLC            Topic: 400

    PROJECT SUMMARY ABSTRACTSingle molecule microscopy is a relatively novel technique that allows individual molecules to be imaged using the optical microscopeIt is of major interest to scientists because it enables the observation of cellular processes at the molecular levela task that is not achievable with classical optical imaging approaches due to the cellular processes being obscured by averag ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Novel strategies for enhanced analysis of repeat disorders

    SBC: ASURAGEN, INC.            Topic: NICHD

    SummaryThe goal of this project is to establish feasibility for diagnostic sequencing of clinically relevant short tandem repeatSTRDNA markers on therd generation MinION nanoporeNPsequencing platformusing tailored STR specific reagents and analytical softwareThis new and innovative modality has the potential to create a paradigm shift in clinical research and diagnostics of repeat disorderas it ca ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Home Cage System for Fine Motor Assessments in Aging Rodent Models

    SBC: VULINTUS, INC.            Topic: NIA

    Project Abstract In this Phase I proposalVulintusIncproposes to develop and testOmniHomea wirelessself contained home cage system for assessing fine motor function in rodentsCurrent methods for longitudinally assessing skilled motor function in aging rodent models are labor intensivetime consuming to administer frequently over long timescalesand stressful to the animalThe proliferation of new rode ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Small Molecule Inhibitor Therapeutic Target for Alzheimer's Disease.

    SBC: abSynapTex, LLC            Topic: NIA

    Project SummaryThe objective of our proposed research is to develop a water soluble molecule that can reduce the levels of amyloid betaAand Drpand prevent abnormal interactions between Aand Drpin Alzheimers diseaseADaffected neuronsOur previous AD studies foundincreased production and accumulation of Aand increased expression of Drpandan abnormal interaction between Aand Drpin AD neurons that was ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Development and non-clinical GLP testing of a new anti-arteriosclerosis gene therapy delivered by engineered adeno-associated viral vectors.

    SBC: Kiromic, Inc            Topic: NHLBI

    AtheroSclerotic CardioVascular DiseaseASCVDis caused by inflammation within arteriesWhite blood cells enter the arterial wallsmacrophages become engorged with lipid cholesterol and summon other inflammatory cells to form plaques which ultimately rupture or occlude the arterykilling down stream tissuee gheart attackASCVD remains a major cause of morbidity and mortality of the elderlyCoronary artery ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Deep Learning Gait Analytics for Primary Care

    SBC: GaitIQ LLC            Topic: NIA

    Alzheimerandapos s diseaseADis the most common cause of dementia and is the third leading cause of death in older adults in the USOvermillion Americans agedand older live with AD and this number is expected to climb to nearlymillion byHoweverfewer thanof individuals with AD have been diagnosedand patients who have the condition are unlikely to receive a full diagnostic workup to identify the cause ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Dose-ranging safety and efficacy studies to advance novel mechanism-of-action small molecule leads to treat obesity-linked type 2 diabetes

    SBC: RIDGELINE THERAPEUTICS LLC            Topic: NIDDK

    ABSTRACTA staggeringof US adults are obeseSince obesity greatly dysregulates glucose homeostasisalmost all obese individuals suffer from TypediabetesT Dor prediabetesThese diseasesand accompanying comorbid chronic health complicationsare largely responsible for burgeoning US healthcare costsUnfortunatelylife style modification programstypically the first line treatment for obesity linked T Drarely ...

    STTR Phase I 2018 Department of Health and Human Services
  10. An Inhaled Clofazimine Formulation for the Treatment of Tuberculosis

    SBC: Lynntech Inc.            Topic: NIAID

    PROJECT SUMMARY According to the World Health Organizationabout one third of the world s population is infected with Mycobacterium tuberculosisMtband as many asof infected individuals will develop active tuberculosisTBat some point after infectionTB is a curable diseaseyet it still has a high mortality rateinmillion people died from the diseaseThe global control of TB is complicated due to the hig ...

    SBIR Phase I 2018 Department of Health and Human Services

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