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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Optimization of a Novel Thread Geometry for Various Orthopaedic Surgery Applications

    SBC: Osteocentric Technologies, Inc.            Topic: NIAMS

    PROJECT SUMMARY ABSTRACTAmong the multiplicity of thread shapesthe buttress thread design remains the historic paradigm for the shape of current orthopedic screwsThe popularity of buttress threads in current orthopedic screw designs is reflected by the advantage of handling high axial thrust in one directionwhich leads to increased shear strength and improved unidirectional pullout resistance comp ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    A Reliable Switched Angle SpinningSASProbe with GradientsPFGfor Proteins in Solid State NMR AbstractSolid state NMRssNMRbiotechnology is emerging as an alternative method of choice for highresolution structure determination for integral membrane proteinsIMPsssNMR provides a unique platform to investigate protein dynamicsand functional studies of wide range of biomolecules in their supramolecular a ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Pediatric Implantable Low-Shear Pulsatile Blood Pump with Physiologic Sensing and Control

    SBC: WINDMILL CARDIOVASCULAR SYSTEMS, INC.            Topic: NHLBI

    Project SummaryAbstract The goal of this project is to develop high level physiological controlimprove low level dynamic piston controland develop hemodynamic sensing capabilities for the pediatric TORVADTMa unique ventricular assist system that delivers low shearsynchronouspulsatile flowusing controlled piston motion within a torus shaped pumping chamberThe pediatric TORVAD is intended for patien ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Overcoming anti-PD-1 resistance by systemic delivery of an oncolytic adenovirus that targets TGF-beta

    SBC: Multivir Inc.            Topic: 102

    Project Summary The overall goal of this proposal is to test a novel systemic Adenoviral therapy that targets transforming growth factorTGFand reverses anti PDresistance to treat advanced breast and lung cancersThis STTR grant application illustrates the synergistic relationship between DrPrem Sethinventor of a novel TGFdecoyand MultiVir Inca leader in clinical development of gene based therapeuti ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Non-invasive device to assist selecting the level-of-amputation in patients with peripheral arterial disease

    SBC: Spectral Md, Inc.            Topic: NHLBI

    AbstractThis is a Phase I SBIR proposal to develop a non contact and non invasive imaging device for assisting cliniciansin selecting the appropriate level of amputationLOAin limbs with peripheral arterial diseasePADSurgeonsprefer to salvage as much limb tissue as possible during amputation to increase patient mobility while decreasingmorbidity and mortalityHoweverclinicians must balance this pref ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Feasibility study of a nanostructural system for bone regeneration in preparation for dental implants

    SBC: NuShores Biosciences LLC            Topic: 100

    Project SummaryCurrent bone grafting techniques for functional rehabilitation with dental implants have limitationshighcostdifficulties with fixation and stabilizationinsufficient bone regenerationhigh morbidity using autogenous block grafts and prolonged healing of up tomonthsExisting synthetic bone fillers cannot match defect shape and volumeare weakly resorbedif at allare not easily and quickly ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Quantitative Analysis of Single Molecule Microscopy

    SBC: Astero Technologies LLC            Topic: 400

    PROJECT SUMMARY ABSTRACTSingle molecule microscopy is a relatively novel technique that allows individual molecules to be imaged using the optical microscopeIt is of major interest to scientists because it enables the observation of cellular processes at the molecular levela task that is not achievable with classical optical imaging approaches due to the cellular processes being obscured by averag ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Novel strategies for enhanced analysis of repeat disorders

    SBC: ASURAGEN, INC.            Topic: NICHD

    SummaryThe goal of this project is to establish feasibility for diagnostic sequencing of clinically relevant short tandem repeatSTRDNA markers on therd generation MinION nanoporeNPsequencing platformusing tailored STR specific reagents and analytical softwareThis new and innovative modality has the potential to create a paradigm shift in clinical research and diagnostics of repeat disorderas it ca ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Home Cage System for Fine Motor Assessments in Aging Rodent Models

    SBC: VULINTUS, INC.            Topic: NIA

    Project Abstract In this Phase I proposalVulintusIncproposes to develop and testOmniHomea wirelessself contained home cage system for assessing fine motor function in rodentsCurrent methods for longitudinally assessing skilled motor function in aging rodent models are labor intensivetime consuming to administer frequently over long timescalesand stressful to the animalThe proliferation of new rode ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Small Molecule Inhibitor Therapeutic Target for Alzheimer's Disease.

    SBC: abSynapTex, LLC            Topic: NIA

    Project SummaryThe objective of our proposed research is to develop a water soluble molecule that can reduce the levels of amyloid betaAand Drpand prevent abnormal interactions between Aand Drpin Alzheimers diseaseADaffected neuronsOur previous AD studies foundincreased production and accumulation of Aand increased expression of Drpandan abnormal interaction between Aand Drpin AD neurons that was ...

    STTR Phase I 2018 Department of Health and Human Services

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