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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Range Encoded Difference Compression of EEG on a chip for Implantable Devices

    SBC: NEURALYNX INC            Topic: 101

    Large scale electrophysiology recordings are recognized as a powerful tool for systems neurobiology and investigation of normal and pathological brain function Buzsaki Continuous high spatial and temporal resolution intracranial electroencephalography iEEG and single neuron recordings from animals and humans are increasingly being used to investigate both normal and pathologic brain f ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Prosthetic System for Large Scale Recording and Manipulation of Neural Circuit Activity in Non Human Primates

    SBC: Gray Matter Research            Topic: 105

    The fundamental objective of the BRAIN Initiative is to understand how dynamic activity in distributed neural circuits mediates human cognitive behavior The non human primate NHP is a key animal model in this effort due to the close similarities of its brain to that of humans and its ability to perform complex cognitive tasks However developing and testing novel hypotheses for how neural cir ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of an Open Speech Signal Processing Platform

    SBC: Flat Earth Inc            Topic: NIDCD

    This proposal will create an open speech signal processing platformThe open computational framework will be used for developing algorithms that will help accelerate acoustic and hearing science researchIt will permit researchers to more rapidly and easily test new algorithms with greater controlperformanceand easeSeveral example systems will be created to show that the platform can be adapted to a ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Development of technologies to advance fast and accurate tools for measuring fluorescence in living cells, with emphasis on developing assays optimized for screening in neuronal cells and brain tissue

    SBC: Montana Molecular LLC            Topic: 105

    Project SummaryMontana Molecular is in the business of developing and marketing genetically encoded biosensors for academic research and drug discovery in living cellsOur biosensors provide robust detection of crucial second messenger signalingincluding DAGPIPcAMP and Caon both fluorescence microscopes and the large installed base of automated plate readerswith metrics that match or surpass those ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Copy Number Variations CNVs are a common cause of disease in humans As of today CNVs are most often detected using microarrays However microarrays are expensive and are not able to effectively detect CNVs below K bp range This project is designed to detect both point mutations and CNVs in one clinical test without having to utilize microarrays It is our goal to develop an easy to use solu ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. A robust assay for detecting agonist bias in living cells

    SBC: Montana Molecular LLC            Topic: 300

    PROJECT SUMMARY The goal this Phase SBIR project is to develop an agonist bias assay for screening drugs that target seven transmembrane G protein coupled receptors GPCRs Phase will establish the feasibility of a robust assay platform to detect when particular GPCR agonists activate both arrestin and G protein pathways This assay will detect responses in living cells on automated fluores ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Ceramic-Metal Interfaces by Functional Grading

    SBC: GLACIGEN MATERIALS, INC.            Topic: A107

    Glacigen Materials proposes a novel technique for producing large-area sheets of functionally graded materials (FGM), which yield robust ceramic-metal interfaces capable of withstanding harsh environments that include high temperatures. Propulsion systems offer some of the harshest possible design conditions from a materials perspective and the demands placed on engineering materials will become m ...

    SBIR Phase I 2017 National Aeronautics and Space Administration
  8. Utilization of the International Space Station to Verify Photonic Devices for Enhanced Space-Based Atmospheric Profiling

    SBC: ADVR, Inc            Topic: H801

    The overall goal of the SBIR effort is completion of Technical Readiness Level (TRL) 5, component validation in a relevant environment, of the key photonics devices for a diode-based, locked wavelength, seed laser system currently being developed for space-based, High Spectral Resolution Lidar (HSRL) measurements. To achieve this goal, AdvR is proposing to the utilize the Materials International S ...

    SBIR Phase I 2017 National Aeronautics and Space Administration
  9. Polarization Entangled Photon Pair Source for Space-Based Quantum Communication

    SBC: ADVR, Inc            Topic: H905

    The overall goal of this NASA effort is to develop and deliver efficient, single-pass quantum optical waveguide sources generating high purity hyper-entangled photon pairs for use in high-rate long-distance links. The new devices will produce hyper-entangled photon pairs with high efficiency, pure spectral properties, and low attenuation, providing the key technology required for deployment of gr ...

    SBIR Phase I 2017 National Aeronautics and Space Administration
  10. High Power, Thermally Optimized Blue Laser for Lidar

    SBC: Bridger Photonics, Inc.            Topic: S101

    To enable widespread and rapid airborne bathymetric lidar to adequate depths in many ocean regions a low-cost, rugged, and high energy pulsed laser source must be developed in the ocean water transmittance spectrum of 450 - 490 nm. The ideal laser source will be high performance for lidar (high pulse energy, high rep rate, short pulse duration) with specific targeted emission spectrum to meet ocea ...

    SBIR Phase II 2017 National Aeronautics and Space Administration

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