Award Data

Project Summary/AbstractEndoscopy is an important tool in the diagnosis and treatment of many gastrointestinal, urological, and kidney diseases. Endoscopes have typically been reusable and are cleaned with high level disinfection (HLD) between patients. Publications and reports in recent years have shown that endoscopes are not sufficiently cleaned between patients, resulting in unacceptable level ...

PROJECT SUMMARY Acute compartment syndrome (ACS) is a complication of extremity injury caused by increasingly elevated intracompartmental pressure (ICP) that eventually compromises perfusion, causing ischemia of the muscles within the compartment. If this persists longer than 6-8 hours, permanent ischemic damage to the muscle occurs (myofibrosis and ischemic contracture). ACS demands immediate sur ...

Project Summary/Abstract NeoTherma Oncology (NTO/www.neothermaoncology.com) has developed a novel non-invasive medical device that delivers mild hyperthermia (HT) loco-regionally as adjuvant therapy to standard of care treatment of abdominal deep-seated tumors. The VectRx™ device, designated “Breakthrough” by the FDA, has demonstrated its ability to safely heat abdominal organs (pancreas, li ...

Project Summary / Abstract Significance Lung cancer is the leading cause of cancer mortality with a 5-year survival rate of less than 20% following standard of care therapy. Problem Despite the use of aggressive surgery, combination chemotherapy and immunotherapy, a major limitation in the control of primary and metastatic non-small cell pulmonary tumors with the use of the systemic administration ...

Project Summary / Abstract Significance: In 2021, more than 75,000 people in the United States died from opioid overdoses. Clinics that treat Opioid Use Disorder (OUD) lack Food and Drug Administration (FDA)-regulated devices that can be prescribed to alleviate cravings and prevent drug use and overdoses. The objective of this SBIR Phase I project is to develop and test a portable neurotherapeutic ...

ABSTRACT Since the first FDA approval of chimeric antigen receptor (CAR) T cell therapy in 2017, the use of engineered T cells expressing specific CARs to treat cancer has generated durable cures for many patients. Nevertheless, a significant subset of patients with B cell malignancies relapse following treatment due to lack of CAR T cell persistence and the ability of cancer cells to change with ...

Project Summary/Abstract The proposed project focuses on creating a simulation system that provides hands-on skills training of musculoskeletal, soft tissue, and ligament function for medical and health science students. Significance: Musculoskeletal (MSK) disorders are the most frequent chronic health problems in the United States. Despite this reality, education in the prevention, diagnosis, and ...

PROJECT SUMMARY Hepatocellular carcinoma (HCC) is a global health burden ranking as the fourth most common and second deadliest cancer in the world. Effective therapeutic strategies for HCC, especially at advanced stages, are limited due to tumor heterogeneity, underlying patient comorbidities, and lack of identified biomarkers for disease management. Overall survival rates for advanced disease ar ...

Project Summary/Abstract This proposed project relates to the development and evaluation of a novel closed-loop long-term oxygen therapy control system that includes an innovative smartphone-based companion software application. We hypothesize that such a system will optimize oxygen delivery in mobile patients, minimize hypoxemia and air hunger during physical exertion, avoid hyperoxia and improve ...

Project Summary/Abstract Minnesota HealthSolutions Corporation in collaboration with the Mayo Clinic proposes to develop an adaptable platform to support patients with behavior change to improve adherence to treatment and prevention for multiple chronic diseases. The proposed platform will utilize remote monitoring combined with health coaching to create behavior change aimed at improving self-man ...