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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Development of a Clinical Screening Platform for Type 1 Diabetes

    SBC: Op-T-Mune, Inc            Topic: NIDDK

    AbstractA major shortfall in clinical care for diabetes is a rapid and accurate screen for progression to diseaseCurrent criteria involve HLA haplotypeand the presence of auto antibodiesAAGenome wide associated studiesGWASrevealed only immune associated genes including HLA as T D predictorsThe ability to differentiate from other diseases was very limitedPre typediabetesp T Dis now being identified ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Definition of pharmacodynamic biomarkers for juvenile dermatomyositis for clinical trials

    SBC: REVERAGEN BIOPHARMA, INC.            Topic: NIAMS

    Definition of pharmacodynamic biomarkers for juvenile dermatomyositis for clinical trials Juvenile dermatomyositisJDMis a rare disease with an incidence rate in the United States ofchildren per million per yearMendez et aland is the most commonmember of the group of inflammatory juvenile myopathiesJMChildren with JDM display a classic heliotrope rashGottronandapos s papulessymmetrical proximal mus ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Establishing a biomarker framework for feasibility studies of vamorolone in vasculitis

    SBC: REVERAGEN BIOPHARMA, INC.            Topic: NIAMS

    Project Summary Abstract Antineutrophil cytoplasmic antibodyANCAassociated vasculitisAAVis a group of rare organ and lifethreatening multisystem diseases involving inflammation and destruction of small blood arteriesAAV appears mediated by neutrophilsbut the mechanisms underlying the neutrophil infiltration and activation are poorly understoodThe disease is treated with glucocorticoids and other a ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Interactive Training in Emergency Operations for the Response Community

    SBC: GRYPHON SCIENTIFIC, LLC            Topic: NIEHS

    In this competitive revision Phase II SBIR, Gryphon Scientific proposes to expand the scope of the ongoing project to support the urgent need to develop and deploy training for two populations of citizen responders at risk of coronavirus exposure. The ongoing Phase II SBIR project focuses on training responders, including Community Emergency Response Teams (CERT) and the Medical Reserve Corps (MRC ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Synergistic Anti-tumor Efficacy of an Interleukin 2 Analog and PD-1 blockade

    SBC: APT THERAPEUTICS, INC.            Topic: 102

    Principal Investigator Program DirectorLastFirstMiddleChenRidong Abstract The durable clinical efficacy of immune checkpoint inhibitors in a variety of cancers has demonstrated the tremendous potential of tumor immunotherapyHowevercurrent approaches are limited to immunogenic tumors that acquire adaptive resistanceInterleukinILimmunotherapy can result in remarkable long term responses in some canc ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Immunomodulatory Therapy for Neuropathic Pain

    SBC: APT THERAPEUTICS, INC.            Topic: 101

    Principal Investigator Program DirectorLastFirstMiddleRidong Chen Project SummaryNeuropathic pain can be difficult to treat with onlyof patients achieving meaningfulandgtpain reliefCurrent therapiese ggabapentinmainly address symptoms by focusing on blocking neurotransmission in the pain pathway with limited efficacypotentially severe side effects and narrow therapeutic indexThusnovel therapies ar ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  7. A nanotechnology approach to higher brain penetrance and sustained brain delivery of intranasal oxytocin

    SBC: DD Therapeutics, LLC            Topic: NIDA

    Psychostimulant abuse is a significant public health problemwithmillion Americans reporting cocaine use andmillion reporting methamphetamine useCurrentlythere are no FDA approved pharmacotherapies to treat stimulant dependencePrevious cocaine medications development efforts have focused on small molecule drugs as they can readily enter the brainThe lack of brain penetrance by large molecules was s ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Novel genotoxicity assay incorporating the toxicogenomics biomarker TGx-28.65 with a direct digital counting

    SBC: AMELIA TECHNOLOGIES LLC            Topic: NIEHS

    Regulatory agencies including EPAFDAECHAand EMA require thorough assessment of the health effects of chemicals present in the environment and marketplaceInterpretation of positive genotoxicity findings using the current standard in vitro testing battery is a major challenge to both industry and regulatory agenciesThese tests have high sensitivitybut suffer from low specificityleading to high rates ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Self-advocacy training for students with cochlear implants entering higher education

    SBC: KDH Research & Communication, Inc.            Topic: NIDCD

    KDH Research andampCommunicationKDHRCsubmits this Phase II Small Business Innovation ResearchSBIRapplication to expand and fully evaluate Cochlear Implant UniversityCIUCIU is an onlineselfadvocacy skills building resource for high school and college students with cochlear implantsCIsagedand their parentsCIU seeks to develop high school and college studentsself advocacy knowledge and skills to supp ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of NanoShield for Ambient handling of labile Bio-products

    SBC: Topogen, Inc            Topic: 300

    Project Summary TopoGENin a strategic partnership with Nanoly Bioscienceproposes to develop ambient condition stable Research Use OnlyRUOproductse genzymesantibodiesand Kitsthrough the use of a syntheticsafeand biocompatible polymer encapsulation technologyNanoShieldNanoShield uses a patent protected photodegradable polyethylene glycolPEGhydrogel network to encapsulate and shield sensitive biomole ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
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