Award Data

DESCRIPTION provided by applicant A key application of deep sequencing is gene expression analysis at the RNA level commonly known as RNA seq Reads from RNA seq cover all regions of an mRNA sequence However sequences derived from the andapos end region are sufficient to indicate gene expression levels All andapos end sequencing methods have revealed that most eukaryotic genes display a ...

Project Summary Abstract The long term objective of this project is the generation of a universal drug discovery platform based on protein arginine methylation mechanisms involved in human disease The importance of protein arginine methylation in the context of human disease has become clear in the last few years with the realization that protein arginine methyltransferases and the target prot ...

Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments for a new thin walledsteerable sheath that can pass through a standard colonoscope port and dexterously maneuver surgical instruments at its tipClinical significance comes from the fact that overpatients per year in the USA have unnecessaryinvasive surgery to remove a section of their colonClinical li ...

DESCRIPTION provided by applicant The global market for nanoparticles NP in biotechnology drug development and drug delivery was estimated to be $ B for and is expected to reach more than $ B by The two most active areas of product development are NPs for drug delivery and for in vivo imaging In these applications it is often critical that he outer surfaces of NPs are functiona ...

DESCRIPTION provided by applicant Sanfilippo disease type B also called mucopolysaccharidosis type III or MPS III is a devastating neuro degenerative genetic disorder of childhood that is fatal There is no cure or effective treatment MPS IIIB is caused by the lack of a lysosomal enzyme called NAGLU alpha N acetylglucosaminidase that is required to degrade heparan sulfate glycosaminoglyca ...

Lack of recruitment of qualified research participants into clinical trials remains to be one of the most important issues in clinical research Studies often struggle to meet recruitment goals on time resulting in costly time extensions underpowered results and in some cases early termination Many reasons attribute to suboptimal recruitment including the challenges related to informing and c ...

The goal of this STTR is to provide a preclinically validated monoclonal antibody or antibody combination for the prevention of respiratory syncytial virusRSVin high risk patients including infants and the elderlyWorldwideof children are infected with RSV before the age ofresulting in an estimatedmillion lower respiratory tract infectionsIn the United States adults overhavemillion RSV infections c ...

Our overarching goal is to develop a monoclonal antibody based product for the prevention of seasonal influenza in high risk patientsIt is estimated there aredeaths annually related to seasonal influenza worldwideIn the United Statestheinfluenza season was classified a high severity season withdeathsandhospitalizations attributed to influenzaserving as a reminder of the continued severity of influ ...

AbstractLEXEO TherapeuticsLLCis an early stage biotechnology company focused on using in vivo gene therapy technologies to treat disorders of unmet medical needLEXEO is developing an in vivo gene therapy strategy as a preventative therapy to protect individuals with aldehyde dehydrogenaseALDHdeficiency from the high risk for esophageal cancerAs the next step in the development paththe goal of this ...

AbstractThe focus of this proposal is the development of therapy to protect the lung with an extracellular anti oxidant defense to treat chronic obstructive pulmonary diseaseCOPDa chronic disorder in which inhaled oxidants from tobacco smokepollution and generated within the lung by activated inflammatory cells perpetuate injury to the lung epithelium and endotheliumThe LEXEO strategy is to use in ...