Award Data

Antimicrobial resistance is a major public health problem worldwide Neisseria gonorrhoeae Ng the causative agent of the sexually transmitted infection gonorrhea has become multidrug resistant and has achieved superbug status Novel therapeutics against Ng are urgently needed Complement C is a key arm of innate immune defenses A mechanism used by several pathogens including Ng to esca ...

DESCRIPTION provided by applicant Over a half billion individuals worldwide are infected with herpes simplex virus type and or type HSV andamp HSV which cause genital herpes Most HSV seropositive individuals are asymptomatic ASYMP and never have any recurrent herpetic disease In contrast a small proportion is symptomatic SYMP with frequent often lifelong bouts of recurrent ...

DESCRIPTION provided by applicant According to the CDC in ischemic heart disease is the leading cause of death worldwide and in the US approximately patients died of ischemic heart disease It is well established in clinical practice that recanalization of he infarct related artery IRA using percutaneous coronary intervention PCI enhances myocardial salvage and outcomes in pa ...

Abstract Nasogastric enteral feeding is a non invasive life saving therapy for older adults who are unable to eat or swallow due to functional decline or age related medical conditions such as stroke Every year nursing facility and home care residents and of stroke patients in the United States receive enteral feedings Nasogastric NG tubes are widely used but pose a serious ...

DESCRIPTION provided by applicant Our goal is to develop a low cost therapy for hepatocellular carcinoma HCC an important worldwide cause of cancer related death with over cases diagnosed each year year survival rates are less than and there is an urgent need for effective therapies Risk factors include chronic hepatitis viral infections cirrhosis of any cause and non alco ...

In prior research and development, the project team developed Woot Math, a web- and app-based mathematics intervention for algebra. With this Phase I funding, the team will develop and test a prototype of Woot Math Polls, an interactive formative assessment platform to facilitate teachers' real-time decision-making while students use Woot Math in the classroom. The prototype will allow teachers to ...

Project Summary Abstract X ray computed tomography CT has been increasingly used in medical diagnosis currently reaching more than million CT scans every year in the US The increasing use of CT has sparked concern over the effects of radiation dose on patients It is estimated that every CT scans will cause one future cancer i e cases of future cancers from million CT scan ...

PROJECT SUMMARY ABSTRACT Accurate and timely detection of circulating autoantibodies against pancreatic islet antigens is critical to both research and clinical care for patients with type diabetes T D However this measurement remains highly variable across commercially available assays and such assays also may not adequately detect particularly low but clinically relevant levels of circulat ...

ABSTRACT Ventilator associated pneumonia VAP is one of the most costly and deadly nosocomial infections Over cases of VAP occur per year resulting in over deaths and a cumulative annual cost to the US Healthcare system over Billion Endotracheal tubes ETT are inserted into the trachea to allow mechanical ventilation They are a critical part of the ventilator circuit but also ...

Abstract Alzheimerandapos s disease AD is the most common dementia in the elderly Currently there is no cure for the disease Pathologically AD is characterized by the presence of extracellular amyloid A plaques and intracellular tau neurofibrillary tangles in patientandapos s brain Although being vigorously pursued multiple attempts targeting on A generation clearance have been fail ...