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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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SBC: Oncosynergy, Inc. Topic: 102
PROJECT SUMMARY More thanpatients are diagnosed each year with glioblastomathe most common primary brain tumorCurrent treatments are inadequate and there have been no major therapeutic breakthroughs in decadesHencethere is an urgent need to develop novel strategies to address this devastating diseaseHoweverdevelopment of an effective treatment for glioblastoma is severely hampered bythe blood brai ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: PROTEIN METRICS INC Topic: 400
Project SummaryGlycosylation is one of the most prevalent and important post translational modifications of proteinsyet it is also one of the most difficult to studyNo single method nor analytical platform can give complete information about the glycosylation in a protein sampleand the analytical methods in current use include both ESI and MALDI single and tandem mass spectrometryat least four typ ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
SBC: MICROPROBES FOR LIFE SCIENCE INC Topic: 101
Project Summary Abstract The brain is by far the most complex and heterogeneous organ in the human bodyFor yearsthere has been a growing and unmet need to develop multielectrode arrays for neurotransmitter sensing in multiple brain regions simultaneouslyDisparate brain regions such as the nucleus accumbensstriatumprefrontal cortexhippocampusand others have been widely known to have greatly varying ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: ABRI SCIENCE, LLC Topic: 300
PhenylketonuriaPKUis a genetic disorder of metabolism characterized by a pathological elevation of phenylalaninePhein the body stemming from a dysfunctional phenylalanine hydroxylase enzymePAHThe resulting high concentrations of Phexcan result in severe intellectual disabilitybehavioral problemsand neurological deficitse gseizuresStrict control of dietary Phe is the primary treatment for PKU curre ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: NEXTRAST, INC Topic: 300
Project SummaryAbstract Our long term goal is to revolutionize the effectiveness of CT imaging for millions of Americans across a broad range of abdominal diseaseDual energy CTDECTprovides powerful clinical diagnostic potential but remains heavily underutilized despite wide scanner availabilityDECT allows materials to be differentiated based on their relative X ray attenuation at low versus high e ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
Enabling dexterous surgery at the tip of a flexible endoscope: A low-cost, disposable, steerable sheath.SBC: ENDOTHEIA INC Topic: NIBIB
Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments for a new thin walledsteerable sheath that can pass through a standard colonoscope port and dexterously maneuver surgical instruments at its tipClinical significance comes from the fact that overpatients per year in the USA have unnecessaryinvasive surgery to remove a section of their colonClinical li ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
Development of a Wearable Fluorescence Imaging Device for Intraoperative Identification of Brain TumorsSBC: BIOPTICS TECHNOLOGY LLC Topic: 102
ABSTRACTApproximatelypeople in the United States have been diagnosed with a primary brain tumorOf thesemalignant gliomasMGsaccount for approximatelyof all intracranial tumorswith an overall patient survival rate of onlyMore than any other cancerbrain cancer has lasting physicalcognitiveand psychological impacts on a patient s lifeand the highest per patient initial cost of careSurgical resection r ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: GalaxyWorks LLC Topic: NHGRI
Project Summary Galactic Core LLC aims to develop a robust, scalable, and managed service for performing enterprise-grade biomedical data analysis. The service will be based on the popular open-source Galaxy application (https://galaxyproject.org/), offering unlimited data storage and compute capabilities with an extremely powerful, flexible, and collaborative environment for analyzing data. ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: CoPlex Therapeutics, LLC Topic: NIA
ABSTRACT Traditional mon therapeutictarget driven approaches to drug development for Alzheimer s diseaseADare becoming increasingly expensive and in many cases disappointingly unsuccessfulBased on preliminary in vitro and in vivo studies we have identified a novel small moleculemethyldimethyloxodihydrobenzo cnaphthyridinecarboxylateBNCthat significantly decreases neuroinflammation and production o ...STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
Development of a novel mobile application to assist in the diagnosis of Fetal Alcohol Syndrome (FAS)SBC: Blue Resonance, LLC Topic: 270
Project Summary AbstractFetal alcohol spectrum disorderFASDis a major public health issue resulting from prenatal alcohol exposurePAEimpacting betweenof the US population and perhaps more thanchildren globally each yearWhen assessing for FASD the following facial features must to be evaluated as part of the diagnostic processpalpebral fissure lengthPFLthinness of the upper vermillionand the smooth ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health