Award Data

Through this STTR contract, we propose to evaluate the efficacy of our vaccine, FlowVax Marburg, in nonhuman primates (NHPs). This will be achieved through four Tasks. In Task 1, we will manufacture the vaccine in a quantity sufficient for the animal studies. In Task 2, we will perform MHC genotyping on a representative population of NHPs and, based on results, select a set of MHC-matched NHPs for ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terrible morbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditional vaccines have contributed greatly to public health, they have some limitations especially in the context of operati ...

Triton Systems propose to integrate 3-D printing into the capabilities of the DLA medical supply chain. This proposed innovation includes development of our medical 3-D printing technology and the demonstration of its capability to print of a variety of life-saving suplies in the DLA medical supply chain such as medical equipment, human tissue, and medicine. Medical 3D printing will enable the DLA ...

This project will develop a new type of polymer concrete using recycled concrete aggregate (RCA) and a proprietarysustainable and biodegradable thermosetting thermoplastic polycarbonate that has the performance properties ofcurrent polymer concrete, but can be melt processed and recycled like asphalt. Consequently it will be morepractical than current polymer concrete in large scale applications l ...

The research resulted in the development of a new approach to hyperspectral imaging utilizing Compressive Sensing. The newly conceived snapshot spectral imager will provide spectral data in a very compact package. It will be virtually indistinguishable from a standard infrared camera but with the added capability for spectral measurement. The camera will thus deliver chemical species information m ...

To address the Chemical and Biological Defense programs (CBDs) need for medical countermeasures against mycotoxin intoxication, PhysicalOptics Corporation (POC) proposes to develop a new Mycotoxin Neutralization Treatment (MyNT). This proposed solution is based on neutralizingmycotoxin from its deleterious effects by acting on multiple levels of mycotoxin metabolism through the novel combination o ...

Infections of the central nervous system (CNS) are associated with brain swelling and increased cerebral blood volume, as well as focal cerebral perfusion deficits, variable levels of cerebral blood flow and cerebral vasculitis. The net result is increased intracranial pressure (ICP) along with significant risk of brain tissue herniation and ischemic syndromes. ICP monitoring is critical in the ma ...

Synthetic opioids including fentanyl and its derivatives pose a serious threat to both civilians and warfighters. The serum half-life of the current FDA-approved antidote for acute opioid poisoning, naloxone, is shorter than that for fentanyl and its synthetic analogs, and thus does not provide effective protection against these threat agents. The mechanism of action of naloxone is by competitive ...

This development is to address the current limitation in respiratory protection neck seal designs. The developed system will allow for a smart splitneck seal design that allows for donning versatility, improved comfort, and will provide feedback to the user regarding seal performance. Theapplication of smart technology will help balance comfort with protection in ensuring that a hermetic neck seal ...

Human butyrylcholinesterase (BChE) is an effective bioscavenger of organophosphates and has potential for acting as a pre-exposure prophylactic or post-exposure treatment for organophosphate (OP) nerve agents, such as sarin. Ideally, a single dose of BChE could be administered and protect the warfighter for days or even weeks while in combat. To be effective in a military setting, especially as a ...