Award Data

This SBIR addresses EPA’s need for improved sampling and analysis technologies to detect Per- and Polyfluoroalkyl Substances (PFAS). PFAS are used in firefighting sprays, at airports, and for wild fires, and have been used in textile treatments (e.g., it is a component in Scotchgard). It is estimated that 65 million Americans are at risk of PFAS exposure in their drinking water. Seacoast propose ...

Advances in materials and automation are rapidly reshaping the American manufacturing economy. These advances must be embraced to sustain a strong manufacturing sector in the United States. Additive manufacturing is possibly the fastest growing example of this trend, growing at an astonishing compound annual growth rate of 25.7%. The plastic materials market for additive manufacturing, valued at $ ...

Of the 300 million tons of plastic produced per year most will require 500 years to biodegrade. Currently only 9% is recycled, and 50 million tons of thermoset plastic produced annually that can't be recycled. _x000D_ _x000D_ This project will develop a sustainable and easily biodegradable polycarbonate plastic that is uniquely a recyclable thermoset resin. We call it a thermosetting thermoplastic ...

The drinking water crisis in Flint, Michigan reminds us that lead remains dangerous and insidious toxicant that can impact public health for months or years before it is detected and remedied.Increasing awareness of lead contamination has motivated the general public to test their own drinking water, but few tools are availiable to help these "citizen scientist" do so effectively.Current lead scre ...

In resource limited settings, rapid and accurate diagnosis of infections is critical for managing potential exposures to highly virulent pathogens,whether occurring from an act of bioterrorism or a natural event. This is especially important for hard to detect intracellular bacterial andalphavirus infections, that overlap symptomatically and often treated empirically due to a lack of reliable and ...

There are currently no vaccines or therapeutics available for Marburg Virus Disease (MVD). Given the specter of weaponization and the terriblemorbidity and high mortality rate of MVD, this represents a critical threat to the operational readiness of the Warfighter. While traditionalvaccines have proven to be a huge contribution to public health, they do have some limitations especially in the cont ...

Marburg virus (MARV) is a filamentous enveloped non-segmented negative sense RNA virus. This viruse is considered to be extremelydangerous with case fatality rates as high as 88-90%. Extensive efforts have gone towards effective vaccines for MARV prevention, however,none have been successfully established as licensed vaccines. Glycoprotein (GP) is the only surface protein of MARV. There are substa ...

Flow Pharma, Inc. is a biotechnology company in the San Francisco Bay Area developing fully synthetic cytotoxic T lymphocyte (CTL)stimulating peptide vaccines for Marburg virus. The FlowVax vaccine platform allows us to create dry powder formulations of biodegradablemicrospheres and TLR adjuvants incorporating class I and class II T cell epitopes. FlowVax vaccines can be designed for delivery by i ...

GeneCapture, Inc. is proposing to develop a rapid in vitro diagnostic prototype using our patented molecular-based CAPTURE (ConfirmActive Pathogens Through Unamplified RNA Expression) assay. Based on the results and experience gained in our Phase I STTR contractHDTRA1-16C-0061: Infectious Disease Diagnostics and Differentiation of Viral vs. Bacterial Infections for Point of Care Applications, we p ...

For effective protection against radiated threats, it is important to understand not only the physics of the threats, but also to quantify the effects they have on mission-critical electrical systems. Radiated vulnerability and susceptibility testing requires delivery of high peak power and peak electric fields to distant targets. The most practical solution to simulate such environments on large ...