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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. FEASIBILITY OF AN INTEGRATED CONTINUOUS PROCESS USING AUTO- MATIC INSTRUMENTATION AND STATAISTICAL ANALYSES TO REDUCE COSTS AND TO INCREASE THE EFFICIENCY OF PEAK DETECTION AND POLLUTION CONTROL IN UNDERGROUND STORAGE TANKS

    SBC: Production Monitoring &            Topic: N/A

    OVER THE LAST SEVERAL YEARS, THE EPA HAS DEVOTED MAJOR EF- FORTS TO IDENTIFY AND DOCUMENT THE MAGNITUDE OF THE RISKS OFENVIRONMENTAL POLLUTION DUE TO LEAKING UDERGROUND STORAGE TANKS (UST). IN APRIL 1987, THE EPA PUBLISHED THE PROPOSED REGULATIONS FOR THE OWNERS AND OPERATORS OF UST, WHICH ARE EXPECTED TO BE FINALIZEDD IN EARLY 1988. THESE REGULATIONS INCLUDE REQUIREMENTS FOR TANK TIGHTNESS TESTS, ...

    SBIR Phase II 1989 Environmental Protection Agency
  2. FEASIBILITY OF AN INTEGRATED CONTINUOUS PROCESS USING AUTO- MATIC INSTRUMENTATION AND STATAISTICAL ANALYSES TO REDUCE COSTS AND TO INCREASE THE EFFICIENCY OF PEAK DETECTION AND POLLUTION CONTROL IN UNDERGROUND STORAGE TANKS

    SBC: Production Monitoring &            Topic: N/A

    N/A

    SBIR Phase I 1988 Environmental Protection Agency
  3. Fluorescent Nanoparticle-Aptamer-Magnetic Bead Sensor for Bioterrorism Detection in Water

    SBC: Operational Techologies Corporation            Topic: C3NCERB4

    Some bioterrorism agents cause disease at very low infective doses and their presence can be masked by the environment. Therefore, ultrasensitive detection is required for homeland defense applications. In this Phase I research project, Operational Technologies Corporation (OpTech) proposes to couple DNA aptamers made by the Systematic Evolution of Ligands by Exponential Enrichment (SE ...

    SBIR Phase I 2004 Environmental Protection Agency
  4. Fluorescent Nanoparticle-Aptmer-Magnetic Bead Sensor for Bioterrorism Detection in Water

    SBC: Operational Techologies Corporation            Topic: N/A

    Some bioterrorism agents cause disease at very low infective doses and their presence can be masked by the environment. Therefore, ultrasensitive detection is required for homeland defense applications. In this Phase I research project, Operational Technologies Corporation (OpTech) proposes to couple DNA aptamers made by the Systematic Evolution of Ligands by Exponential Enrichment (SELEX) proce ...

    SBIR Phase I 2004 Environmental Protection Agency
  5. FOLLOWING A POST-IRRADIATION THERMAL ANNEAL CYCLE

    SBC: Materials Engineering &            Topic: N/A

    THIS RESEARCH WILL DETERMINE THE CHARACTERISTICS OF FATIGUE INITIATION LIFE, FATIGUE CRACK GROWTH RATES, AND SLOW-STABLECRACK EXTENSIONS FOLLOWING A POST-IRRADIATION ANNEAL. FATIGUE INTITIATION LIFE WILL BE DETERMINED WITH SMOOTH SPECIMENS OF 308 STAINLESS STEEL WHICH HAVE BEEN ANNEALED AND THEN CYCLED IN PRESSURIZED, HIGH-TEMPERATURE WATER. SUBMERGED ARC WELD STEEL (LINDE 80 FLUX) WILL BE PARTIAL ...

    SBIR Phase I 1983 Nuclear Regulatory Commission
  6. Hand-Held Fluorometer Using Selex DNA Aptamer Strip Assays to Detect Cryptosporidium and Encephlitozoon

    SBC: Systems & Processes Engineering Corporation            Topic: N/A

    Systems & Processes Engineering Corporation (SPEC) proposes to develop receptors composed of DNA oligomers ("aptamers") from a combinatorial library for binding and detecting Cryptosporidium parvum oocysts and three species of Encephalitozoon spores. Aptamers will be generated by the Systematic Evolution of Ligands by EXponential enrichment (SELEX) combinatorial chemistry technique. SELEX aptamers ...

    SBIR Phase I 2001 Environmental Protection Agency
  7. Handheld FRET Aptamer Sensor to Satisfy the Beaches Act

    SBC: Operational Techologies Corporation            Topic: 06NCERC2

    Operational Technologies Corporation (OpTech) proposes to couple the ultrasensitivity of fluorescence-based detection with the high affinity and selectivity of DNA aptamers as improved replacements for antibodies to detect fecal indicator organisms in fresh and marine recreational waters. Fluorescence Resonance Energy Transfer (FRET) aptamer assays for fecal indicator organisms will be demon ...

    SBIR Phase I 2007 Environmental Protection Agency
  8. Handheld FRET Aptamer Sensor to Satisy the Beaches Act

    SBC: Operational Techologies Corporation            Topic: N/A

    Operational Technologies Corporation (OpTech) proposes to couple the ultrasensitivity of fluorescence-based detection with the high affinity and selectivity of DNA aptamers as improved replacements for antibodies to detect fecal indicator organisms in fresh and marine recreational waters. Fluorescence Resonance Energy Transfer (FRET) aptamer assays for fecal indicator organisms will be demonstrat ...

    SBIR Phase I 2007 Environmental Protection Agency
  9. Handheld FRET-Aptamer Sensor for Chem-Bio Threats

    SBC: Operational Techologies Corporation            Topic: J

    "Operational Technology Corporation (OpTech) proposes to couple the ultrasensitivity of fluorescence-based detection with the high selectivity of synthetic DNA aptamers as replacements for antibodies to detect chemical and biological (CB) terrorism threats in 10 minutes or less from a variety of swabbed surfaces and liquid matrices. OpTech has previously provided strong proof-of-concept for a rap ...

    SBIR Phase I 2011 Environmental Protection Agency
  10. HIGH SENSITIVITY URANIUM BIOASSAY

    SBC: Eastern Analytical Inc.            Topic: N/A

    DETERMINATION OF URANIUM IN THE URINE OF WORKERS IS REQUIRED BY THE NRC AT NUCLEAR FACILITIES. EXTREMELY LOW CONCENTRATIONS OF URANIUM, ESPECIALLY IN SMALL SAMPLES, ARE DIFFICULT TO MEASURE USING EXISTING TECHNOLOGY. FUTURE NRC PLANS TO CHARACTERIZE BIOAVAILABLE URANIUM FRACTIONS COMPRISING THE URANIUM BODY BURDEN WILL REQUIRE EVEN HIGHER SENSITIVITIES. HIGH SENSITIVITY TECHNOLOGY DEVELOPED FOR UR ...

    SBIR Phase I 1992 Nuclear Regulatory Commission

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