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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Clinical Testing of the First Suspension BHK-M Cell Platform Derived Biotherapeutic

    SBC: EXPRESSION THERAPEUTICS LLC            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT The long term objective of current project is to commercialize a novel coagulation factor product manufactured using a novel production cell linedesignated ET i BHK M with a primary indication of treatment of anti drug antibodies that develop following the treatment of congenital hemophilia A with factor VIIIfVIIIreplacement productsExpression Therapeutics has developed mu ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less thanCurrentlythere is no effective treatment for advanced diseaseOne major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal responseEvidence suggests that cancer associated pancreatic stellate cellsCAPaSCproduce the stromal collagenThe ECM laid down by CAPaSC is considered to be o ...

    STTR Phase II 2018 Department of Health and Human Services
  3. Microhook nerve tape: A nerve repair coaptation aid

    SBC: Axion Biosystems, Inc.            Topic: 101

    Project Summary We will finalize development of a microhook based device for quick and consistently effective repair of nerve injuriesThismicrohook nerve tapeconsists of an array of microscale hooksdistributed across a fineflexible meshwork and embedded in a biologic backingThis device will be used during nerve repair surgeries in place of microsutures to wrap around and bind the approximated ends ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Quantifiable Thermal Therapy Using Magnetic Resonance Thermometry Imaging

    SBC: NeoTherma Oncology Inc.            Topic: 102

    Pancreatic Ductal AdenocarcinomaPDACis the third leading cause of cancer related death in the United Statesand is characterized with dismal odds due to advanced disease at late stage diagnosisTheyear survival rate ranges fromfor patients with non resectable diseaseof patientstofor patients with resectable tumorsandltof patientsPDAClike most solid tumorsis highly hypoxicresulting from both poor oxy ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Hemonauts- Interactive Digital Media for Increased STEM Learning Among Chronically Ill Children and Their Support Networks

    SBC: Thrust Interactive, Inc.            Topic: 500

    Abstract This proposal seeks to create the Hemonauts suite of interactive digital mediaIDMto serve chronically illfrequently hospitalized students in grades five through eight and their support networks toiIncrease STEM content knowledge through gameplayiiIncrease knowledge of and intent to persist in STEM careersandiiiIncrease disease literacy to improve patient self advocacytreatment compliancea ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Development of a Wearable Band-Aid Biosensor System for Alcohol Monitoring

    SBC: Design-Zyme LLC            Topic: 450

    Project Abstract The goal of this Phase I SBIR is to develop a non invasive wearable dermal deviceBand Aidcapable of extracting and sensing ethanol from interstitial space using reverse iontophoresisnot sweat!and transmitting the results wirelessly to a Bluetoothcapable deviceThe proposed band aid patch will be easily applied to the epidermisand will provide monitoring of ethanol levels in a cost ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Advanced Prodrug Treatment for CML

    SBC: INHIBIKASE THERAPEUTICS            Topic: 399

    Inhibikase Therapeutics is a clinical stagebio pharmaceutical company that has developed a novel prodrug formulation for the popular anticancer agent GleevecGleevectreatment is commonly accompanied by significantburdensome gastrointestinal side effectsfatigue and myalgias that erode therapy success due to poor patient complianceInhibikaseandapos s prodrug of GleevecIkTProProcompletely blunts these ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. Administrative Supplement to Promote Diversity for Development of a robust, color-based, disposable, standalone anemia test for low-resource settings (Parent grant: 1 R43 HL139250-01A1)

    SBC: Sanguina, LLC            Topic: NHLBI

    Parent Project AbstractHLSAnemiaor low blood hemoglobin levelsis a public health problem affecting overbillion people worldwideOverbillion of people affected live in low resource settingsCurrentlyanemia is typically diagnosed with a complete blood countCBCvia a clinical hematology analyzer that is clinic or hospital basedTo that endSanguina has completed development of a first generation AnemoChec ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Clinical Data Intelligence & Advanced Analytics to Reduce Drug Diversion across the Care Delivery Cycle and Drug Supply Chain in Health Systems

    SBC: Invistics Corporation            Topic: NIDA

    Project Summary Abstract This SBIR project will research mechanisms to detect when Health Care WorkersHCWsin hospitals steal ordivertlegal drugs either to abuse themselves or to illegally sell to othersWe focus on HCWs in hospitals because of the alarming rates of substance abuse and diversion in hospitalswith multiple studies finding roughlyof our nation s nursesanesthesiologistsand pharmacists a ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Isolation and Identification of Prebiotic Nutrient Components

    SBC: Design-Zyme LLC            Topic: NIA

    ABSTRACT Studies of the microbiome of older individuals has shown greatly reduced numbers of known beneficial bacteria coinciding with a greater presence of potentially detrimental bacterial strainsNot surprisinglythe decrease in beneficial microbes coincides with a loss of anti inflammatory activity and genes associated with short chain fatty acid productionThis age related decline in the gut mic ...

    SBIR Phase I 2018 Department of Health and Human Services

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