Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Discovery of T-type Calcium Channel Antagonists from Multicomponent Reactions and Their Application in Paclitaxel-induced Peripheral Neuropathy

    SBC: Regulonix            Topic: 101

    Summary Abstract Chemotherapy induced peripheral neuropathyCIPNis detected inof cancer patients during all phases of cancerSensory symptoms in the hands and or feettypically in astocking glovepatternare commonand manifested as painnumbnessand or tinglingCIPN can result in chemotherapy dose reduction or discontinuationand can also have long term effects on the quality of lifeThe course of CIPN can ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Developing a High-throughput Bioprinting Platform for 3D iPSC-derived Liver Tissues for Early Drug Screening

    SBC: Allegro 3D, Inc.            Topic: NIBIB

    SummaryCurrent drug discovery and development practices have resulted in considerably long development time frames and low success rates of new drugs reaching marketFew improvements on efficiency and poor cost versus benefits in Randamp D have also caused post approval costs as high as $billion inTogetherthese factors drive the demand to improve current practices and turn to new innovative technol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Using Virtual Reality Psychological Therapy to Develop a Non-Opioid Chronic Pain Therapy

    SBC: CognifiSense, Inc.            Topic: 600

    Project SummaryAbstract Chronic pain affects overmillion Americanscosting society about $billion annuallyDespite numerous pharmacological and non pharmacological therapiesoverof chronic pain sufferers feel little control over their painThe need for alternativemore effective pain therapies is urgentas the U Sfaces a widening prescription opioid abuse epidemicCognifiSense has developed a patent pend ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Radiation Sterilizable, RFID Tagged Vials for Biomedical Samples

    SBC: Biotillion, LLC            Topic: OD

    Abstract The Specific Aim of this Phase IIbPhase II competitive renewalSBIR proposal is to advance the prototypes we developed under our Phase I and II SBIR grants into commercial productionWe will produce SBSformat radiation sterilizable electronically tagged sample vials that can be read at ultra low temperaturesHundreds of millions of SBSvials are sold each year and each of these vials must be ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Therapeutic Antibody for RSV IIB

    SBC: Trellis Bioscience, LLC            Topic: R

    Abstract Respiratory syncytial virusRSVis a leading cause of serious lower respiratory tract disease in infantsleading annually todeaths andmillion hospitalizations worldwideClose to $billion has been invested by the RSV community over the past two decades in clinical trials seeking to improve upon the marketed monoclonal antibody Synagiswhich is only approved for prophylaxis of very low birth wei ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A Transporter Platform Technology For Discovery of Drugs to Treat Autoimmune Disease

    SBC: Apricity Therapeutics            Topic: 300

    Project Summary Abstract ! The longterm goal of Apricity TherapeuticsIncApricityis to target pharmacological transporters in the Solute Carrier superfamilySLCto treat diseases for which there are no available pharmacological therapies or current therapies are inadequateSLCs are emerging drug targets because of their numerous associations in human genetic studies with a wide array of common and rar ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. SIRT1 and BCL6: Dual Biomarkers of Endometriosis and Endometrial Receptivity

    SBC: CiceroDx, Inc.            Topic: NICHD

    PROJECT SUMMARY ABSTRACT Endometriosis is a common and poorly understood disease affecting millions of women around the worldThe impact on fertility and pelvic pain is estimated to cost $billion dollarsbut this does not include the costs to treat IBSinterstitial cystitis and the cost of failed Assisted Reproductive TechnologyARTcyclesIt is estimated thatof failed ART cycles are due to undiagnosed ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Peripherally-restricted and long-acting MAS1(LA-MAS1) agonists for pain

    SBC: Peptide Logic LLC            Topic: NIDA

    PROJECT SUMMARYThe current USopioid crisisfueled by overmillion annual prescriptions of mu opioid receptorMORagonist analgesics and characterized by unprecedented levels of addictionabuse and death by overdosehas emphasized the need for novelefficaciousnon addictive and safe analgesicsThe proposed program seeks to develop a first in classFICperipherally restricted and long acting MASLA MASagonist ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Non-Invasive Assay for Diagnosis and Treatment of Endometriosis

    SBC: Ribomed Biotechnologies, Inc.            Topic: NICHD

    Project Summary AbstractEndometriosis affects up toof women of reproductive age often causing painful symptoms and an increased risk of infertilityA major clinical problem is the lack of a noninvasive and early diagnostic procedureThe diagnostic gold standard is laparoscopic surgery and histology of the recovered lesionsThe goal of this Phase I project is to develop a noninvasive diagnostic test f ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Multi-center prospective study assessing a panel of microRNAs as a non-invasive test for endometriosis

    SBC: Dot Laboratories, Inc.            Topic: NICHD

    Project Summary Endometriosis is an inflammatory disorder that affects up toinwomen of reproductive agewhich is characterized by the attachment and growth of endometrial cells outside the uterus on the walls of the pelvic cavity and organsThis condition affectsof women with chronic pelvic pain and may be found in up toof infertile womenAlong with dysmenorrheapainful periodsendometriosis creates in ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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