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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Novel iobio analysis supporting genome scale data quality control

    SBC: Frameshift Labs, Inc.            Topic: 172

    Project Summary Identifying disease causing genetic variants is a complex process often involving the analysis of the genomes of affected patients and their immediate families When employing these state of the art techniques however the number of patients receiving a successful diagnosis is still only at approximately One reason for this low diagnosis rate is the presence of localised dat ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Interactive Digital Intervention to Prevent Violence among Young Adults

    SBC: Happy People Games, LLC            Topic: NICHD

    Project Summary Abstract Sexual assault SA is prevalent among students at and year colleges The rate of SA among college students is three times greater than the rate in the general population making prevention on college campuses a public health priority There are no college SA prevention programs that document reductions in SA in a rigorous research design Digital applications that us ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Infant Slumber Safety An Immersive Smartphone Experience

    SBC: MEDIA REZ LLC            Topic: NICHD

    Abstract This study aims to assess the feasibility and acceptability of using state of the art interactive technology and social media and to improve adherence with the safe sleep guidelines by young mothers and their families Public health messages which can be effective in older adults are not achieving the same results with young mothers They do not always make choices supported by medical r ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of New Improved Perflutren Ultrasound Contrast Agent

    SBC: MICROVASCULAR THERAPEUTICS LLC            Topic: NHLBI

    Three ultrasound contrast agents Definity Optison and Lumason are FDA approved for echocardiography in the U S Definity currently has over market share Definity s dominance in the market is due to its ease of administration via IV infusion and robust ultrasound contrast Definity has shelf life of years and must be stored under refrigerated conditions Definity has an unpleasant ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A novel approach to treat non alcoholic steatohepatitis NASH

    SBC: Mitotherapeutix LLC            Topic: 300

    Abstract The Specific Aim of this Phase I STTR proposal is to test the feasibility of treating non alcohol steatohepatitis NASH by increasing mitochondrial metabolism which is the main pathway for lipid catabolism in the liver NASH is a stage of non alcohol fatty liver disease NAFLD that has progressed to a pathological state NASH can lead to cirrhosis leading to liver failure or hepatocel ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. High Resolution Microbiome Profiling System

    SBC: SHORELINE BIOME, LLC            Topic: NIDA

    Shoreline Biome is developing kits methods and software as part of a comprehensive high resolution amplicon microbiome profiling system that revolutionizes ease of use while solving several problems with current S rRNA gene microbiome protocols The entire bp rRNA ITS gene space is targeted permitting veteran researchers to compare directly to previous assays encompassing any portion of t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A fluorescent reporter detecting precise homologous recombination transgenesis activity

    SBC: KDT, LLC            Topic: NICHD

    The broad long term objective and specific aims of the fast track SBIR research are to create a reagent RecombiRED for use in microinjection of embryos for identifying a subset of embryos as recombination competent injections The ability to quickly identify genome editing events in an embryo allows researcher to quickly make precision animal models of human disease states Precise animal m ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. I PARTS INTEGRATED PLATFORM FOR ANTI CANCER RADIATION THERAPEUTICS SCREENING

    SBC: PACT & HEALTH LLC            Topic: NCI

    We propose to develop an integrated module for high throughput clonogenic cell survival assay in cancer drug screening I PARTS Integrated platform for anti cancer radiation therapeutics screening combines the recent advances in cell culture automation microfluidics and high speed image analysis with the highthoughput X ray irradiation Commercially the product also has the scope and feasibili ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. VIRTUAL REALITY FOR MOBILE PAIN CONTROL

    SBC: MEDIA REZ LLC            Topic: NIDA

    Under this Small Business Innovation Research SBIR Phase II project Topic the Contractor will produce anditeratively test a virtual reality VR intervention with diverse populations of patients with chronic pain The Contractorwill develop and refine VR content based on patient and clinician feedback develop and implement a plan forusing the VR content as a therapeutic tool in a ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. PREDICTIVE BIOMARKERS OF ADVERSE REACTIONS TO PROSTRATE CANCER RADIOTHERAPY

    SBC: L2 DIAGNOSTICS, LLC            Topic: NCI

    The overall objective of this project is to advance the development of a clinically usefully multiplex assay todetect biomarkers of radio sensitivity that will identify subsets of prostate cancer patients for whichradiotherapy should be contraindicated This assay will be capable of predicting the risk of developingadverse effects principally urinary morbidity and rectal injury resulting from ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health

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