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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Multiscale ab initio QM/MM and Machine Learning Methods for Accelerated Free Energy Simulations

    SBC: Q-CHEM INC            Topic: 400

    Q-Chem is a state-of-the-art commercial computational quantum chemistry software program that has aided about 60,000 users in their modeling of molecular processes in a wide range of disciplines, including biology, chemistry, and materials science. In this proposal, we seek to significantly reduce the computational time (now around 500,000 CPU hours) required to obtain accurate free energy profile ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel, Low-Cost Device to Guide Peripherally Inserted Central Catheter (PICC) Line Placement

    SBC: PICCOLO MEDICAL, INC.            Topic: NIA

    Abstract In the United States alone, more than three million peripherally inserted central catheters (PICCs) are placed each year to provide IV therapies, where in about half of cases navigation through the venous system is typically performed blind, or without navigation guidance. Improper PICC placement is relatively common, is costly, and has serious complications for critically-ill patients. U ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. SUPPORTING WHO ONCHOCERCIASIS ELIMINATION PROGRAMS: PROGRESSING A HIGHLY SENSITIVE AND ULTRA-SPECIFIC RAPID DIAGNOSTIC TEST TO COMMERCIALIZATION READINESS

    SBC: BIG EYE DIAGNOSTICS INC            Topic: NIAID

    PROJECT SUMMARY / ABSTRACT WHO needs new, highly sensitive and ultra-specific lateral flow assays (LFA) to support its endeavors to eliminate onchocerciasis, a disease also known as river blindness affecting 18 million people, with another 218 million living at risk of contracting the disease. Onchocerciasis is fought by mass drug administration (MDA). WHO critically needs new diagnostic tests to ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Novel, Targeted Small Molecule Inhibitor of the Nucleotide Salvage Pathway to Treat Underserved Tumor Types

    SBC: TRIANGLE THERAPEUTICS INC.            Topic: NCI

    PROJECT SUMMARY Trethera, a clinical stage biopharmaceutical company, has developed a small molecule drug, TRE-515, to target the nucleoside salvage pathway via a key rate-limiting enzyme, deoxycytidine kinase (dCK). We have shown that dCK is expressed at high levels in a variety of solid tumors, and TRE-515 selectively targets cancer cells based on their high expression of, and dependence on, dCK ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Evaluation of anti-fibrotic and anti-inflammatory semi-synthetic oxysterol, Oxy210, as a therapeutic drug candidate for non-alcoholic steatohepatitis

    SBC: Max Biopharma, Inc.            Topic: 300

    ABSTRACT Pathologic tissue fibrosis, impelled by uncontrolled wound healing responses to acute or chronic injury is a significant problem in many organs including kidney, lung, and liver. Liver fibrosis is a major health problem that causes morbidity and mortality in the affected patient population. Liver fibrosis occurs in various pathologies including chronic alcohol exposure, non-alcoholic fatt ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. A multicenter study in bronchoscopy combining Stimulated Raman Histology with Artificial intelligence for rapid lung cancer detection- The ON-SITE study

    SBC: INVENIO IMAGING INC            Topic: NCI

    Project Summary and Abstract Lung cancer accounts for about 25% of all cancer deaths in the US, as it is often caught at an advanced stage when treatment options are limited. This has led to the institution of screening programs with low-dose CT, resulting in ~1.6 million pulmonary nodules detected every year, most of them (~80%) in the periphery of the lung. Tissue biopsy is the standard of care ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. IVD EIT a Nonanimal Kit and Service for the Detection of Ocular Irritants: Phase II

    SBC: LEBRUN LABS LLC            Topic: 142

    Abstract Currently, the Draize live rabbit eye test is the benchmark to distinguish consumer products and materials that are safe from those that are hazardous and can cause mild, moderate, or severe ocular damage. However, new laws are currently being, or are planned to be, implemented in California, the United States, and the European Union to ban the use of animals for ocular irritation testing ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Development of ALM-488 for nerve and ureter visualization during abdominal surgery

    SBC: ALUME BIOSCIENCES, INC.            Topic: NCI

    PROJECT SUMMARY Fundamental to the goals of surgery are functional preservation of critical nerves and minimization of post- operative patient morbidity. Unfortunately, inadvertent nerve injury during surgery continues to be a major cause of post-surgical patient morbidity due to the inability of surgeons to visualize nerves during surgery. Nerve injury is a frequent postoperative complication of ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Koli: A non-surgical solution for gallstone disease

    SBC: Koli            Topic: 300

    Symptomatic gallstone disease affects nearly 5 million people in the United States and consumes over $6.3B annually. Complications occur when gallstones move from the wide body of the gallbladder and enter the narrow system of ducts connecting the gallbladder to the small intestine. The incidence of gallstones increases with age and is higher in women and obese people. Other risk factors include p ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Clustered home assessment of visual fields in patients with glaucoma

    SBC: Vivid Vision, Inc.            Topic: NEI

    Project summary/abstractGlaucoma is the second leading cause of irreversible vision loss in Americans. Effective treatment requires the patient to take visual field tests over time, to monitor for progression of visual field loss. In many patients there is no progression, but when it occurs it must be detected as quickly as possible in order to save vision by using a more aggressive treatment. Pat ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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