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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Ocular Flare Meter OFAM Development Phase II

    SBC: Chromologic LLC            Topic: N

    DESCRIPTION provided by applicant Although there are to individuals in the United States with active uveitis there is no clinically accepted method for quantitative assessment of ocular flare that would result in rapid non invasive diagnosis of uveitis Current methods of diagnosis for uveitis involve a thorough examination of the eye with a slit lamp microscope and ophthalmo ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. sEH Inhibitors to Treat Neuropathic Pain

    SBC: Eicosis, LLC            Topic: NIEHS

    DESCRIPTION provided by applicant With this proposal we aim to further the development of novel and safe oral inhibitors of sEH for the treatment of peripheral neuropathy in diabetic patients Preclinical studies with our candidate EC demonstrated efficacy for diabetic neuropathy EicOsis has selected EC for its efficacy with good PK ADME properties and stability to enter further develo ...

    SBIR Phase II 2016 Department of Health and Human Services
  3. An interactive wearable device for measuring and motivating hand use after stroke

    SBC: FLINT REHABILITATION DEVICES, LLC            Topic: NICHD

    DESCRIPTION provided by applicant Approximately of the individuals who survive a stroke each year have persistent upper extremity impairment One reason why this percentage is so high is that the number of rehabilitative practice movements that they perform is too small Ideally individuals with a stroke would augment their clinical therapy by regularly attempting to use their imp ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Neonatal EEG Monitor NEMO

    SBC: Quantum Applied Science And Research, Inc.            Topic: NICHD

    DESCRIPTION provided by applicant Neonatal seizures are a common neurologic diagnosis in the Neonatal Intensive Care Unit NICU occurring in some newborns annually in the US and are frequently associated with long term deleterious consequences including intellectual disability cerebral palsy epilepsy and other neurodevelopmental disabilities Early detection and treatment can resul ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. A high throughput high resolution and high sensitivity scanning X ray fluorescence microprobe for elemental mapping in cell cultures and tissues for medical research and diagnosis

    SBC: Sigray, Inc.            Topic: 400

    DESCRIPTION provided by applicant Trace elements are well known to have critical roles in a wide variety of diseases including cancer and neurodegenerative diseases such as Alzheimerandapos s and Wilsonandapos s diseases Due to their biological importance there have been numerous studies performed with spectroscopy techniques such as laser ablation inductively coupled mass spectrometry LA I ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Kinome wide Cell Based Assays

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: 300

    DESCRIPTION provided by applicant The human genome encodes protein kinases that catalyze the phosphorylation of client proteins Signal transduction mediated by protein impacts virtually all aspects of cellular physiology from the coordination of the cell cycle and cll division to apoptosis Not surprisingly the deregulation of kinases is implicated in many diseases including diabetes in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. A Web Enabled Database for Rapid Metagenomic Biocatalyst Discovery and Validation

    SBC: Radiant Genomics, Inc.            Topic: 300

    DESCRIPTION provided by applicant Radiant Genomics proposes to develop an integrated enzyme discovery service the Enzyme Variant Engine EVE built upon the largest cloned metagenomic sequence collection reported to date The goal is to combine a publicly accessible search engine richly annotated sequence database arrayed sample library and LIMS automation platform to deliver novel enzyme ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. TriadWeb An easy to use web based platform for protein engineering

    SBC: PROTABIT LLC            Topic: 400

    DESCRIPTION provided by applicant Monoclonal antibodies and other protein based therapeutics represent a $ billion and growing market with broad applications in the treatment of cancer metabolic diseases and other human disorders Thus any technology that facilitates the discovery of useful protein variants will have a major impact in biology and medicine application areas include drug ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Intrasaccular Flow Disrupters for Small and Ruptured Aneurysms

    SBC: SEQUENT MEDICAL, INC.            Topic: 101

    DESCRIPTION provided by applicant The long term goal of this Phase SBIR program is to provide a highly effective minimally invasive treatment option for patients suffering from small broad necked intracranial aneurysms To address the unmet clinical need for treating small broad necked aneurysms Sequent Medical Inc has developed the Woven EndoBridge or WEB device The WEB represents a ...

    SBIR Phase II 2016 Department of Health and Human Services
  10. Optimizing a Smartphone Application for Individuals with Eating Disorders

    SBC: Recovery Record Research            Topic: 104

    DESCRIPTION provided by applicant An important development in the field of public health is the emergence of behavioral health technologies and mobile health mHealth applications apps Recovery Record RR is a self monitoring app that aims to enhance engagement in recovery for individuals with eating disorders EDs and has demonstrated wide appeal and reach over its year period of prot ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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