Award Data

Applied Physical Sciences Corp. will develop a distributed buoy detection system using an advanced acoustic receiver. The sonar array will consist of a vertical line of vector hydrophones to maximize gain against unwanted ambient noise and provide 20+nm detection ranges for targets of interest. Additionally the single vector vertical line array will provide target bearing and tracking data that ca ...

The focus of this proposal is to develop BioPhalanx a rapid, hand portable, robust detection system for multiplexed detection of bio-threats, in harsh environments. We have developed a new method of detection called Combinatorial Probe Analysis (CPA), which provides an exponential increase in detection reliability. This type of analysis will greatly reduce false positives and false negatives; in a ...

This proposal describes a battery operated cryocooler to be used for cooling High Purity Germanium (HPGe) detectors, commonly used for the detection of gamma rays. HPGe detectors are highly suitable for identifying nuclear materials, which is of great interest in the Department of Homeland Security (DHS) applications. HPGe detectors need to operate near 110 K requiring refrigeration for portable H ...

This proposal describes a transportable cryocooler to be used for cooling High Purity Germanium (HPGe) detectors, commonly used for the detection of gamma rays. HPGe detectors are highly suitable for identifying nuclear materials, which is of great interest in the Department of Homeland Security (DHS) applications. HPGe detectors need to operate near 110 K requiring refrigeration. High cooling per ...

Rapid detection of pathogens in air and/or liquid samples is of paramount importance to minimize a potential threat of biological warfare agent attack as well appearance of emerging infectious diseases. Current methods, particularly those that target aerosols are determined by the efficiency and speed of sample preparation which comprises collection of air sample its conversion into a liquid sampl ...

To develop advanced ¿channel-to-droplet¿ sample extraction and purification functions on a compact cartridge that is free of sensitive and complex microfluidic components, Core Microsolutions (CMSS) and Professor Sung Cho of the University of Pittsburgh propose to integrate Electrowetting-on-Dielectric (EWOD) droplet handling and in-droplet concentration capabilities with well proven channel-bas ...

The proposed research is to determine feasibility of developing a stable, simple, rapid method of detecting the nucleic acid (NA) from bioterrorism agents. This method would be based on Investigen?s novel and elegant ?smartDNA? technology. This system utilizes a peptide nucleic acid probe cocktail to produce a rapid color change when probes hybridize to complementary NA sequences. Phase 1 will: 1) ...

Emergency responders require a hand-held instrument in the field for screening specific sites for biological threat materials. In Phase I we will complete a design for an instrument, called MENTOR, which meets the needs and specifications of the emergency response teams. Innovative methods will be used to test electronic and software modules to transition the MENTOR system from a desktop to hand-h ...

This proposal describes a completely automated, NanoBioSentinel sample preparation instrument for biodefense. The NanoBioSentinel will contain two modules: a bead-based Sample Capture and Purification Module (SCPM) front-end and a microchip-based NanoBioProcessor Module. Built partly upon existing devices, the SCPM will use immunocapture and multi-dimensional purifications to process milliliter vo ...

Gamma ray and neutron emitting isotopes can be located and identified with the use of a directional gamma ray and neutron detection system having excellent spectroscopic energy resolution. Segmented germanium gamma-ray detectors are the best detectors for such a system. Recent evolutions in germanium detector technology, imaging techniques, electronics, and cryogenics make such a system viable. To ...