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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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SBC: BioTime, Inc. Topic: 100
ABSTRACT Stroke is a leading cause of disability worldwideGloballythere aremillion stroke survivors each year who have significant neurological deficits including sensory and motor disabilityleading to excessive socioeconomic burdenCell therapy using primary MSCs has been actively explored by us and others as a therapeutic solution to this unmet medical needHoweversince the therapeutic efficacy of ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Mitovation, Inc. Topic: 101
Neonatal hypoxia ischemia is a known cause of cerebral damage resulting from inadequate blood flow and or oxygen delivery to the infant brain beforeduringor after birthThe occurrence among hospital deliveries isperfull term births with a drastic increase among premature newbornsThe deficit in oxygen delivery to the brain results in extensive damage and severe disabilitiesRestoration of blood flow ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Production and Characterization of Human Immunoglobulin Producing Goats for Diagnostic Reagents and TherapeuticsSBC: SAB CAPRA, LLC Topic: NIAID
Project Summary A research plan is proposed to engineer goats that produce fully human immunoglobulinThese animals will be evaluated as a candidate platform system for production of both targeted therapeutic immunoglobulin as well as reagent antibodies for standards and controls of serological assays of human clinical samplesPrevious studies have demonstrated that ungulates such as cattle can prod ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Validating the MicroKine Assay for Use in Identifying Personalized Precision Therapies for Pediatric SepsisSBC: PreDxion Bio, Inc. Topic: NICHD
Project Summary Abstract PreDxion BioLLC is a precision medicine diagnostic company developing an assay platformthe MicroKineassay cartridge and readerthat measures serum proteins in less thanminutes from a single drop of bloodThis fastactionable information allows for the first time individualized precision medicine aimed at reducing pediatric morbidity and mortality in pediatric sepsisthe number ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: C. Light Technologies, Inc. Topic: NINDS
Abstract The goal of this project is to validate an innovativehighly sensitive retinal eye tracking technologythe tracking scanning laser ophthalmoscopeTSLOas a prognostic and monitoring tool for neurodegenerative disordersnamely multiple sclerosisMSThe applications of effective treatments for multiple sclerosis are constrained bythe absence of methods for early detection andquantitativehighly sen ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: ADELPHI TECHNOLOGY INC Topic: N/A
DESCRIPTION (provided by applicant): We propose to develop a commercial neutron source for the treatment of brain and liver cancer based on boron neutron capture therapy (BNCT). Boron-containing compounds are injected into a patient's bloodstream and accumulate in a malignant tumor. When irradiated with neutrons, the boron atoms preferentially capture neutrons and decay, releasing short-range radi ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: Aguila Technologies, Inc. Topic: N/A
DESCRIPTION (provided by applicant): In several recent PA's, the NIH has articulated a clear vision for the future of medical imaging systems a) enhanced spatial or temporal resolution, b) better sensitivity and specificity, c) multi-modality, and d) new functional or molecular imaging or spectroscopy methods. Owing to their unique combination of properties, direct conversion gamma radiation imagi ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: APEX DX, LLC Topic: N/A
DESCRIPTION (provided by applicant): In developed countries, approximately 1:1000 children are born deaf and approximately 1:300 children are born with some lesser degree of hearing loss. At least 50% of the deafness and hearing impairment is likely to be attributable to genetic factors, with a large number of genes involved in the pathogenesis. The molecular genetic basis for the majority of case ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: ARTYX PHARMACEUTICALS, INC. Topic: N/A
DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most prevalent joint disease, causing joint pain and dysfunction. OA is also associated with substantial co-morbidity and reduces life expectancy. Pharmacologic therapy is limited to symptom modification and disease-modifying therapies are currently not available. Furthermore, even symptom-modifying therapies are limited in efficacy a ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: BANDEMAR NETWORKS, LLC Topic: N/A
DESCRIPTION (provided by applicant) Skilled Service Personnel (SSP) support emergency response organizations during an emergency incident involving weapons of mass destruction and include laborers, operating engineers, carpenters, ironworkers, sanitation workers and utility workers. SSP called to an emergency incident rarely have recent detailed training on the chemical, biological, radiological, ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health