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SBC: L2 DIAGNOSTICS LLC Topic: NIAMS
ABSTRACT Systemic autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus are characterized by polyclonal T cell activation driving the production of pathogenic class switched autoantibodiesThe class switchedsomatically mutated antibodies are generated from germinal centerGCB cellsA subset of effector CDT cellsknown as T follicular helperTfhcellshas been shown to play an ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
The Novel Biopsy Needle Design and Delivery System to Minimize Needle Deflection and Optimize Needle Positioning to Improve Lesion Sampling Accuracy Using a Co-registered MRI/US Fusion Biopsy PlatformSBC: ProDevice Medical Supplies and Equipment LLC Topic: 101
Project Abstract Accurate diagnosis of prostate cancer is essential for individualized treatment decisionsWith more recent advances in multiparametric magnetic resonance imagingmpMRIsuspicious cancer lesions can be identifiedCo registered MRI ultrasound fusion targeted biopsyMRF TBallows the sampling of specific lesions of concern within the prostate has emerged as the preferred diagnostic procedu ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: L2 DIAGNOSTICS LLC Topic: NICHD
ABSTRACT Kawasaki DiseaseKDis a febrile childhood vasculitis with potentially catastrophic clinical outcomesUntreatedone in five children develop coronary artery aneurysms causing significant morbidity and mortalityTypical KD presents as a febrile illness andgtdays in children andltyears oldThere are no diagnostic tests for KDit is diagnosed clinically based on a fever andgtdays with at leastofphy ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Hybrid DNN-based Transfer Learning and CNN-based Supervised Learning for Object Recognition in Multi-modal Infrared ImagerySBC: TOYON RESEARCH CORPORATION Topic: 1
On this effort Toyon Research Corp. and The Pennsylvania State University are developing deep learning-based algorithms for object recognition and new class discovery in look-down infrared (IR) imagery. Our approach involves the development of a hybrid classifier that exploits both transfer learning and semi-supervised paradigms in order to maintain good generalization accuracy, especially when li ...STTR Phase I 2018 Department of DefenseNational Geospatial-Intelligence Agency
SBC: SIGNATURE RESEARCH, INC. Topic: 1
Signature Research, Inc. (SGR) and Michigan Technological University (MTU) propose a Phase I STTR effort to develop a learning algorithm which exploits the spatio-spectral characteristics inherent within IR imagery and motion imagery.Our archive of modelled and labeled data sets will allow our team to thoroughly capture the variable elements that will drive machine learning performance.The overall ...STTR Phase I 2018 Department of DefenseNational Geospatial-Intelligence Agency
SBC: ADELPHI TECHNOLOGY INC Topic: N/A
DESCRIPTION (provided by applicant): We propose to develop a commercial neutron source for the treatment of brain and liver cancer based on boron neutron capture therapy (BNCT). Boron-containing compounds are injected into a patient's bloodstream and accumulate in a malignant tumor. When irradiated with neutrons, the boron atoms preferentially capture neutrons and decay, releasing short-range radi ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: Aguila Technologies, Inc. Topic: N/A
DESCRIPTION (provided by applicant): In several recent PA's, the NIH has articulated a clear vision for the future of medical imaging systems a) enhanced spatial or temporal resolution, b) better sensitivity and specificity, c) multi-modality, and d) new functional or molecular imaging or spectroscopy methods. Owing to their unique combination of properties, direct conversion gamma radiation imagi ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: APEX DX, LLC Topic: N/A
DESCRIPTION (provided by applicant): In developed countries, approximately 1:1000 children are born deaf and approximately 1:300 children are born with some lesser degree of hearing loss. At least 50% of the deafness and hearing impairment is likely to be attributable to genetic factors, with a large number of genes involved in the pathogenesis. The molecular genetic basis for the majority of case ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: ARTYX PHARMACEUTICALS, INC. Topic: N/A
DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most prevalent joint disease, causing joint pain and dysfunction. OA is also associated with substantial co-morbidity and reduces life expectancy. Pharmacologic therapy is limited to symptom modification and disease-modifying therapies are currently not available. Furthermore, even symptom-modifying therapies are limited in efficacy a ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: BANDEMAR NETWORKS, LLC Topic: N/A
DESCRIPTION (provided by applicant) Skilled Service Personnel (SSP) support emergency response organizations during an emergency incident involving weapons of mass destruction and include laborers, operating engineers, carpenters, ironworkers, sanitation workers and utility workers. SSP called to an emergency incident rarely have recent detailed training on the chemical, biological, radiological, ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health