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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
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SBC: VALA SCIENCES, INC. Topic: N/A
DESCRIPTION (provided by applicant): Heart failure is a leading cause of mortality in modern society, and is results from the death of cardiac myocytes. Contractile function of failing hearts can be restored by injecting the heart with embryonic stem cell-derived cardiac myocytes (ESCMs) which integrate into the host tissue. To facilitate production of ESCMs, high throughput screening systems are ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: VALA SCIENCES, INC. Topic: N/A
DESCRIPTION (provided by applicant): We propose to develop an automated screen for small molecules that modulate insulin promoter activity. The assay is based upon a mouse insulinoma, MIN6, that normally expresses insulin mRNA. This cell was engineered to stably contain two cassettes that use a fluorescent reporter protein to monitor insulin promoter activity and a housekeeping gene activity. The ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: VESTAN INC Topic: N/A
DESCRIPTION (provided by applicant): The objective of this grant is to develop fluorescence endoscopy instrumentation to facilitate the surgical management of breast cancer, with possible application to other types of cancer. The specific aims for this project are to develop a combination holographic notch filter adapter and switchable high-intensity LED light source adapter for currently availabl ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: VISDEX CORP Topic: N/A
DESCRIPTION (provided by applicant): Photopolymerization has provided a powerful tool for tissue engineering through localized synthesis of therapeutic materials in situ. To date, strategies to create photopolymerized networks on the surface of a tissue, such as the inner lumen of a blood vessel or on the fracture surface of a bone have received the most attention. The proposal will demonstrate a ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
SBC: VIVO LABORATORY, INC. Topic: N/A
DESCRIPTION (provided by applicant): Apoptosis is well recognized as an important biological process that controls cancer development and progression and the efficacy of chemotherapeutic drugs depends largely on their ability to induce apoptosis. Modern biology has suggested that cancer drug discovery based on molecular differences between tumor and normal cells is a feasible approach. Bcl-2, a cr ...STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
Developing an efficient E-cigarette aerosol generation and exposure system for rodent models with aerosol characteristics equivalent to those inhaled by E-cigarette usersSBC: AUTOMATE SCIENTIFIC, INC. Topic: NIDA
Abstract E cigaretteE ciguse has rapidly proliferated worldwideIt is speculated that E cig use may exceed conventional cigarette use withinyearsCigarette smoking is the leading preventable cause of death and disabilityAs E cigs are a relatively new productstudies are needed to determine their long term detrimental effectssome of which may be similar to the long term detrimental effects of nicotine ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Validating the MicroKine Assay for Use in Identifying Personalized Precision Therapies for Pediatric SepsisSBC: PreDxion Bio, Inc. Topic: NICHD
Project Summary Abstract PreDxion BioLLC is a precision medicine diagnostic company developing an assay platformthe MicroKineassay cartridge and readerthat measures serum proteins in less thanminutes from a single drop of bloodThis fastactionable information allows for the first time individualized precision medicine aimed at reducing pediatric morbidity and mortality in pediatric sepsisthe number ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Inter-examiner Agreement of a Novel Device for the Measurement of Cervical Dilation in Labor: A Randomized Controlled TrialSBC: Elm Tree Medical Inc. Topic: NICHD
Measurement of cervical dilation during late pregnancy and labor informs decisions in the management of labor and deliveryPrior published research suggests that practitioners are onlytoaccurate when judging cervical simulatorsWhen measuring laboring womentwo practitionersandaposmeasurements agree onlyof the timeDrEva Martin of Elm Tree Medical Incdeveloped a novel deviceDilaCheckto enable practiti ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: DFUSION INC. Topic: NICHD
Althoughyear olds are onlyof the U Ssexually active populationthey account for nearlyof themillion new cases of sexually transmitted infectionsSTIeach yearAlthough historically lowthe U Steen pregnancy rate continues to be one of the highest in the developed worldEvidence based prevention efforts can help avoid the costs and health consequences associated with STIs and unwanted teen pregnancy amon ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: C. Light Technologies, Inc. Topic: NINDS
Abstract The goal of this project is to validate an innovativehighly sensitive retinal eye tracking technologythe tracking scanning laser ophthalmoscopeTSLOas a prognostic and monitoring tool for neurodegenerative disordersnamely multiple sclerosisMSThe applications of effective treatments for multiple sclerosis are constrained bythe absence of methods for early detection andquantitativehighly sen ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health