Award Data

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Laser Technology Inc. (LTI) proposes a Phase II SBIR research project to further develop a Compact Shearography System, Analysis Method and Software for micro-crack detection in concrete. There is an urgent need to detect and characterize fine cracks in concrete that form because of various damage mechanisms including alkali-silicate reaction, delayed ettringite formation or frost damage. Fine s ...

DESCRIPTION (provided by applicant): The applicant, Leversense, has recently licensed the piezoelectric-excited millimeter-sized cantilever (PEMC) sensor technology from Drexel University. The PEMC sensors are relatively simple devices that measure concent ration of protein biomarkers through antibody-antigen binding chemistry and have a demonstrated sensitivity that is 100,000 times higher than t ...

DESCRIPTION (provided by applicant): The first step in any protein therapeutic exercise is expression of the protein. In some cases, this step is not troublesome. For increasing numbers of designer proteins and requirements for post-translation modificatio ns, however, enhanced expression and increasing protein yield have become very challenging tasks. Cost of goods is an important factor. In some ...

DESCRIPTION (provided by applicant): Rather modest success has yet been achieved in expressing and purifying membrane proteins as a prerequisite to obtain high resolution structures. Only 124 unique structures for membrane proteins have been resolved out o f gt 30,000 soluble proteins. This bottleneck can be divided into at least three major parts: i) the difficulty to express quantitatively and ...

DESCRIPTION (provided by applicant): It has been well established that the ubiquitin pathway plays an important role as a key regulator of neuronal biology. The ubiquitin pathway enzymes are essential and critical mediators of synaptic adaptability in matu re neurons, and dysfunctional ubiquitin pathway enzymes or regulation is associated with diverse neurodegenerative disorders. Deubiquitinating ...

DESCRIPTION (provided by applicant): A major bottleneck in protein expression and purification is the costs associated with functional protein production in biomedical, biopharmaceutical and other research fields. Because proteins of interest originating f rom eukaryotic organisms often require specific components for post- translational events to mature into active forms, their functional product ...

DESCRIPTION (provided by applicant): Interstitial cystitis (IC) is a chronic, severely debilitating disease of the urinary bladder. It can be described as a chronic inflammatory condition of the bladder wall, characterized by urinary frequency and urgency, and severe suprapubic and/or pelvic pain. Presently, there is limited medical therapy for IC and new and effective treatment is a major unmet ...

DESCRIPTION (provided by applicant): Hypoxia-inducible factor-1 (HIF-1) is the primary regulator of the transcriptional response of mammalian cells to low oxygen and other stresses that lower ATP levels. Our investigations on the mechanism of action of HIF -1 have led us to the fundamental observation that adenosine 5'-monophosphate-activated protein kinase (AMPK) activity is important for tumor b ...

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