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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A Device to Assess Sleep Breathing in Children at Home

    SBC: APNEOS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Sleep-related breathing disorders (SRBDs), such as sleep apnea, take a heavy public health toll, especially on children. Mounting evidence suggests that these disorders can impact physical and mental development. Diagnosing and understanding these disorders are major challenges. Polysomnography, an imperfect gold standard, is not practical to apply on a wide ba ...

    SBIR Phase I 2007 Department of Health and Human Services
  2. Gridless Simulation of Flow-MPHV Interaction

    SBC: Applied Scientific Research            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to develop a CFD software for the grid-free simulation and analysis of the complex dynamics of the Fluid-Structure Interaction (FSI) associated with Mechanical Prosthetic Heart Valve (MPHV) "systems" as they respond to physiologically realistic 3-D pulsatile flow. The final product will be the first commercially available grid-f ...

    SBIR Phase II 2007 Department of Health and Human Services
  3. Drug-eluting Tracheobronchial Stents to treat Obstruction caused by Lung Cancer

    SBC: ARAVASC, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Airways can be obstructed by a variety of diseases resulting in breathing difficulties and compromised quality of life for the patients. Lung cancer is one of the major diseases causing airway obstruction. According to the American Cancer Society it is the single largest cause of cancer deaths in the United States (173,000 estimated new cases diagnosed in 2006) ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. Human Monoclonal Antibody To Treat P. aeruginosa Infections in Cystic Fibrosis

    SBC: ARIDIS PHARMACEUTICALS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Cystic Fibrosis (CF) is an autosomal recessive disorder, which leads to the abnormal composition and physical properties of airway secretions in CF patients. Additionally, the lungs of CF patients are particularly susceptible to chronic bacterial infections with >80% of CF patients becoming chronically infected by 18 years of life with mucoid forms of Pseudomon ...

    STTR Phase I 2007 Department of Health and Human Services
  5. Recombinant Enzyme Fusion Protein for Lysosomal Storage Disorders

    SBC: ARMAGEN TECHNOLOGIES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Zhang, Yun Abstract There are over 40 lysosomal storage disorders, and most of these diseases affect adversely the central nervous system (CNS). The mainstay of treatment is enzyme replacement therapy (ERT). However, ERT is not effective for the brain, because the enzymes do not cross the brain capillary wall, which forms the blood-brain barrier (BBB) in vivo. ...

    SBIR Phase II 2007 Department of Health and Human Services
  6. Magnetic Encoded Sortable Particle Arrays

    SBC: ARRAYOMICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of this project is to develop a novel 'liquid array' platform, based on Encoded Sortable Particle (ESP) technology. ESPs are optically-encoded microfabricated particles that can be manipulated using magnetic force. They are manufactured on commercially available photolithographic equipment using efficient and robust techniques borrowed from the semi-con ...

    SBIR Phase II 2007 Department of Health and Human Services
  7. Sustained Release Inner Ear Delivery of Corticosteroid

    SBC: AURITEC PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long term goal of this research is to reduce or eliminate deafness due to certain diseases of the inner ear by developing sustained release formulations for anti-inflammatory drugs which can be implanted directly into the inner ear. The initial project will be to develop an inner ear delivery system for corticosteroids. The specific aims of this proposal ar ...

    SBIR Phase I 2007 Department of Health and Human Services
  8. Sustained release calcineurin inhibitors for the prevention of graft rejection

    SBC: AURITEC PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long term goal of this research is to reduce toxicity and graft rejection due to dosing problems with the calcineurin inhibitors by developing sustained release subcutaneous injectable formulations for the drugs tacrolimus and cyclosporine. Substantial inter-and intra-patient variability means that even frequent drug monitoring cannot eradicate rejection du ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. Sustained Release Apomrophine for Parkinson's Disease

    SBC: AURITEC PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The broad long term goal of this work is to develop sustained release subcutaneous drug delivery systems in order to achieve a more continuous dopaminergic stimulation in the treatment of Parkinson's Disease (PD). The immediate goal of this project is to develop an injectable sustained release formulation for the recently approved anti-Parkinsonian agent apomor ...

    SBIR Phase II 2007 Department of Health and Human Services
  10. Hispanic Stress Inventory Adolescent Immigrant and Non-Immigrant (HSI-A I/NI)

    SBC: Behavioral Assessment, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Hispanic adolescents are at elevated risk for mental health and related behavioral problems. Culturally specific stress is associated with the risk for these problems. The objective of the proposed research is to develop a stress assessment inventory for Hispanic adolescents. This Phase II study builds upon the results of the Phase I feasibility study. The stud ...

    SBIR Phase II 2007 Department of Health and Human Services

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