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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Decide, Discover, and Do: An Intervention for Community-Dwelling Older Adults with Alzheimer's and Other Dementias

    SBC: HEARTHSTONE ALZHEIMER CARE, LTD            Topic: NIA

    Project Summary Abstract Family caregivers are an integral part of the U Shealth care systemasof all care for persons with Alzheimer s disease is done by unpaid caregiversPersons with dementia also receive approximatelytimes the amount of informal care that a cognitively intact older adult does roughlyhours per monthSothere is an urgent need for products and programs that enable family caregivers ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Optical probe for real-time assessment of periodontal health status

    SBC: MixZon, Inc.            Topic: NIDCR

    Project Summary AbstractPhysical SciencesIncPSIin collaboration with The Forsyth InstituteCambridgeMA is proposing to develop a technology that will address a major unmet medical need in periodontologythe lack of tools to quantitatively and objectively assess the health disease status of the gingival soft tissuesThe proposed technology will combine high resolution micro Optical Coherence Tomograph ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. LEAD IT! An App to Enable Persons with Early Stage Dementia to Lead Group Activities for Their Peers

    SBC: HEARTHSTONE ALZHEIMER CARE, LTD            Topic: NIA

    Project Summary AbstractBehavioral disturbances are consistently reported to be among the most stressful aspects of providing care to persons with dementiaPWDPWD also often undergo an existential crisisespecially in the early stagesas they feel a loss of purpose in lifeThis is unfortunatebecause many skills remainespecially for persons in the early stages of dementiaPESDAlsomany PESD maintain a de ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Novel targeted therapy for pancreatic cancer

    SBC: Abtelum Biomedical, Inc.            Topic: 102

    ABTELUM BIOMEDICALINCaims to advance a humanized anti DEspR neutralizing antibodyABTwith a stabilized IgGkappa frameworkas a potential first in class therapy for pancreatic adenoductal carcinomaPDACwith the worst prognosis among all cancersTo advance IND enabling experiments for ABTthis SBIR Phase I tests the therapeutic hypothesis that ABTwill inhibit metastatic progression and increase overall s ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Development of first-in-class TREM-1 inhibitors for neovascular retinal diseases

    SBC: SIGNABLOK, INC.            Topic: NEI

    Project Summary Abstract Retinal neovascularizationRNVis a determinant cause of vision loss in retinopathy of prematurityROPdiabetic retinopathyDRand retinal vein occlusionRVOIn the USaboutof premature infants are affected by ROP annually and aboutmillion adults overyears have DRRVO is the second most common sight threatening retinal vascular disorder after DRComplications of conventional therapeu ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Development of a sample-to-answer sequencing pipeline for detection of viral infections and co-infections in immunocompromised transplant patients.

    SBC: ARC Bio, LLC            Topic: NIAID

    ABSTRACTNext generation sequencingNGShas the potential to revolutionize how infectious disease is diagnosed and treatedenabling the detection of a wide variety of pathogens in a single testHoweverdespite the increasing adoption of molecular diagnostics in clinical virology and microbiology labsNGS has not become widespread due to its costturnaround timeand the technical and computational expertise ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Exploration of Low-Cost Long-Timescale Free Energy Perturbations on FPGAs

    SBC: Silicon Insite, Inc.            Topic: 400

    Drug discovery is challenging and expensiveespecially in the phase of lead optimization whichpredicts binding to a targetComputational approaches can add substantial valueComputingrelative binding free energiesRBFEbetween congeneric molecules using molecular dynamicsMDgreatly reduces the search space and considerably improves convergenceThe Silicon TherapeuticsSTXINSITE platform uses an RBFE proto ...

    STTR Phase I 2018 Department of Health and Human Services
  8. Clinical Translation of a Novel Diagnostic Agent to Predict Immunotherapy Response in Solid Tumors

    SBC: CytoSite BioPharma Inc.            Topic: 102

    Over the past three years an entirely new cancer treatment paradigm has emerged following the FDA approval ofdifferent checkpoint inhibitors for a number of indications includingmetastatic melanoma and non small cell lung cancerThese new agents work by effectively releasing the brakes on the immune system that normally limit the body s natural responses to tumor cells and have generated long term ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Voice Recognition for Improved Prosthesis Control

    SBC: Liberating Technologies, Inc.            Topic: NICHD

    PROJECT SUMMARY ABSTRACT It is generally agreed that only about half of upper limbULamputees wear a prosthesisand this is often because it does not return enough function for the burdens of weightdiscomfortuncosmetic appearancelack of durabilityetcOne primary reason for lack of prosthesis acceptance is the lack of ability to control the device effectivelyDifficulties with control result because mu ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. MDCT Quantification of hepatic tumor viability for assessment of cancer therapy

    SBC: IQ Medical Imaging LLC            Topic: 102

    Project SummaryAbstract Tumor imaging quantification is critical for diagnosisstagingand treatment evaluationand multi detector CTMDCTis the clinical imaging modality commonly used for patients diagnosed with hepatic malignancy because of its relatively low cost and wide availabilityConventional tumor quantification using either linear or volumetric measurement has demonstrated significant limitat ...

    STTR Phase II 2018 Department of Health and Human Services

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