Award Data

THE PRIMARY OBJECTIVE OF THIS STUDY IS TO EVALUATE THE FEASIBILITY OF DEVELOPING A REAL-TIME 3-D DYNAMIC ROBOT VISION SYSTEM FOR USE STS ASSEMBLY, CONSTRUCTION, AND ROUTINE MAINTENANCE. THE BASIC TECHNIQUE PROPOSED FOR STUDY USES THE "FLOW-FIELD" INFORMATION IMPLICIT IN ALL IMAGED SCENES INVOLVING RELATIVE MOTION BETWEEN IMAGING SENSOR AND VIEWED OBJECTS, AND USES IT TO GENERATE A DYNAMICESTIMATE ...

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THE RAPID GROWTH AND MATURATION OF OUR CAPITAL INFRASTRUCTURE HAS CREATED A MAINTENANCE BURDEN GREATER THANEVERE BEFORE. A CRITICAL ASPECT OF THE INFRASTRUCTURE MAINTENANCE PROCESS IS THE INPUT FROM INSPECTIONS AND CONDITION SURVEYS OF THE LARGE STRUCTURES (E.G. DAMS, BRIDGES, ROADS) THAT CONSTITUTE OUR INFRASTRUCTURE SYSTEMS. THE TRADITIONAL AND TIME HONORED TECHNIQUE OF VISUAL INSPECTION BY TRAI ...

TESTING ITS IMMUNOTHERAPEUTIC POTENTIAL THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP PROCESSES FOR THE PRODUCTION OF B-CELL GROWTH FACTOR (BCGF) AND TO TEST THE POTENTIAL APPLICATIONS OF BCGF FOR THE TREATMENT OF HUMAN IMMUNOPATHOLOGICAL CONDITIONS. BCGF MAY BE USEFUL AS AN IMMUNOTHERAPEUTIC AGENT IN THE TREATMENT OF PRIMARY IMMUNODEFICIENCY DISEASES AND POSSIBLY IN CERTAIN B-CELL LEUKEMI ...

THE OBJECTIVE OF THIS RESEARCH PLAN IS TO ISOLATE A CDNA SEQUENCE ENCODING TUMOR NECROSIS FACTOR (TNF) AND, BY MANIPULATION OF THAT SEQUENCE, TO PRODUCE AND SECRETE THE MATURE TNF PROTEIN FROM THE YEAST SACCHAROMYCES CEREVISIAE. PREVIOUS WORK ON TNF HAS SHOWN IT TO HAVE CYTOSTATIC OR CYTOLYTIC ACTIVITY IN VITRO AGAINST A NUMBER OF TRANSFORMED CELL LINES AND TO HAVE TUMOR NECROTIC ACTIVITY AGAINST ...

LYMPHOTOXIN IS A LYMPHOKINE WHICH HAS POTENT ANTITUMOR ACTIVITY. IT IS A GLYCOPROTEIN WITH A MOLECULAR WEIGHT OF 25,000 DALTONS. DUE TO THE MINUTE AMOUNT PRODUCED BY LYMPHOCYTES, EVALUATION OF ITS PHARMACEUTICAL POTENTIAL REQUIRES THAT IT BE CLONED AND EXPRESSED IN A SUITABLE HOST. IN ORDER TO OBTAIN THE CORRECT GLYCOSYLATION PATTERN, WE PROPOSE TO EXPRESS IT IN MAMMALIAN CELLS. IN PHASE I, WE PLA ...

WE PROMISE TO DEVELOP METHODS FOR THE LARGE-SCALE PRODUCTION OF HUMAN COLONY STIMULATING FACTORS (CSF) FROM NORMAL HUMAN PERIPHERAL BLOOD LYMPHOCYTES. THE FERMENTATION METHODS EMPLOYED WILL BE SIMILAR TO THOSE USED FOR THE PRODUCTION OF NATURAL INTERLEUKIN-2. WE ARE PRODUCING HUMAN IL-2 FOR CLINICAL EVALUATION BY THE BIOLOGICAL RESPONSE MODIFIERS PROGRAM (BRMP). PURIFIED CSFS WILL BE TESTED IN PRE ...

WE PROPOSE TO DEVELOP A METHODOLOGY BY WHICH THE GENES CODING FOR AUTOIMMUNE DISEASE-SPECIFIC PROTEIN ANTIGENS CAN BE RAPIDLY CLONED USING RECOMBINANT DNA TECHNIQUES. THE SYSTEM WHICH WE ARE USING LENDS ITSELF TO HIGH-LEVEL EXPRESSION OF THESE ANTIGENS AS HYBRID PROTEINS IN E. COLI. THIS FACILITATES PRODUCTION OF THESE ANTIGENS FOR IN PHASE I A CDNA LIBRARY WILL BE CONSTRUCTED FROM HUMAN THYROID T ...

WE PROPOSE TO IDENTIFY THE GENES FOR AUTOIMMUNE DISEASE-SPECIFIC PROTEIN ANTIGENS BY THE USE OF RECOMBINANT DNA TECHNIQUES. THE SYSTEM THAT WE ARE USING LENDS ITSELF TO HIGH-LEVEL EXPRESSION OF THESE ANTIGENS AS HYBRID PROTEINS IN E. COLI. THIS APPROACH FACILITATES PRODUCTION OF THESE ANTIGENS FOR THE PURPOSE OF ANTIGEN CHARACTERIZATION, GENERATION OF ANTIBODIES AND DEVELOPMENT OF IMMUNODIAGNOSTIC ...

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