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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Large Throughput Multiplex Analysis of Gene Expression

    SBC: Genaissance Pharmaceuticals            Topic: N/A

    We will develop resources for large-throughput analysis of gene expression. The complement of genesexpressed in a given cell varies during development, in disease states and in response to hormonal sgene expression are the basis of cancer. This project will show the feasibility of "Multiplex Profillarge-throughput strategy for characterizing changes in gene expression and for retrieving the variap ...

    SBIR Phase I 1995 Department of Health and Human Services
  2. Novel Repeat Elements for Genome Analysis

    SBC: Genaissance Pharmaceuticals            Topic: N/A

    The goal of this Phase I project is to isolate and characterize new chromosome-specific human repetelements. The resulting probes will be valuable for cytogenetic cancer diagnostics. Our preliminaryrandom amplification of polymorphic DNA (RAPD) is a valuable approach for the discovery of chromosompolymorphic repetitive DNA elements. Phase I will involve systematic and high- throughput employmentge ...

    SBIR Phase I 1995 Department of Health and Human Services
  3. N/A

    SBC: Genaissance Pharmaceuticals            Topic: N/A

    N/A

    SBIR Phase I 1995 Department of Health and Human Services
  4. Biodegradable Antibiotic Beads for Osteomyletis

    SBC: BIOTEK, INC.            Topic: N/A

    Deep infection following open fractures or bone surgery are a challenging orthopedic problem. The ugentamicin-impregnated PMMA cement or beads has become a successful part of the management of osteomchronic post-fracture infections, but these materials have disadvantages, such as the need for a secthe PMMA, the existence of many gentamicin-immune organisms, and highly non-uniform delivery. The obp ...

    SBIR Phase I 1995 Department of Health and Human Services
  5. Biodegradable Bone Matrix for Peptide Delivery

    SBC: BIOTEK, INC.            Topic: N/A

    There is need for a convenient biodegradable bone substitute to support soft tissue and stimulate bWe will combine its unique BIOPORE material with the recently characterized osteogenic growth peptidthis objective. BIOPORE is a porous biodegradable material developed by BIOTEK. OGP is a 14-aminoacinormally present in serum, which stimulates proliferation and activity of osteoblasts and increasesde ...

    SBIR Phase I 1995 Department of Health and Human Services
  6. Biodegradable Polylactide-Co Glycolide Medical Cements

    SBC: BIOTEK, INC.            Topic: N/A

    Osteomyelitis is a serious orthopedic problem, and its prevention or treatment using systemic antibcomplications and is often unsuccessful. The use of polymethylmethacrylate beads or bone cement to dto bone sites does reduce the incidence of post- operative bone infections, but these non-porous poldrug delivery vehicles, and because they are non-biodegradable materials they cannot be used where bd ...

    SBIR Phase I 1995 Department of Health and Human Services
  7. Cell Lines with Receptors Important to Mental Health

    SBC: Bunsen Rush Laboratories, Inc.            Topic: N/A

    The long-term objective of this project is to develop cell lines that stably express G-protein coupreceptors important to mental health. The specific aim of this application is to demonstrate the feaby developing a permanent cell line expressing the human D1 dopamine receptor (d1R). Cell lines whicreceptors will be useful in functional assays for finding new ligands (drugs) which will be highly ss ...

    SBIR Phase I 1995 Department of Health and Human Services
  8. Long Pulse Laser Treatment of Psoriasis

    SBC: CANDELA CORPORATION            Topic: N/A

    The investigators will study the efficacy of long pulsed laser treatment for psoriasis. Psoriasis iwhich is often chronic in nature. Current treatment modalities do not result in a cure of this chroninvestigators wish to develop a safe and efficacious dye laser for psoriasis. The laser radiation wiselective absorption by erythrocytes in the capillaries of the dermal papillae. Subsequent thermal nm ...

    SBIR Phase I 1995 Department of Health and Human Services
  9. Picosecond Laser for Dermatology Applications

    SBC: CANDELA CORPORATION            Topic: N/A

    Analysis of the characteristic interaction time for laser tissue irradiation suggests that picosecopulses will operate in a temporal regime where photomechanical effects are dominant. At least in thethis mechanism is expected to lead to an improved treatment. To access this new laser treatment regimust be developed. Current picosecond laser systems of energy in excess of 1 mJ are complex and costo ...

    SBIR Phase I 1995 Department of Health and Human Services
  10. Bridge Amplification for Blood Banking Tests

    SBC: CBR LABORATORIES, INC.            Topic: N/A

    The long term objective of this project is to develop a novel diagnostic testing methodology that csafety and volume of the blood supply. The basis for this method is an innovative amplification techBRIDGE allows for the simultaneous detection of a plurality of organisms or cellular antigens in a ssimplicity and sensitivity of BRIDGE will allow more extensive screening while reducing the overall(c ...

    SBIR Phase I 1995 Department of Health and Human Services

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