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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. N/A

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    N/A

    SBIR Phase I 2001 Department of Health and Human Services
  2. LOW-COST, GEIGER-MODE MUAPD ARRAYS FOR CYTOMETRY

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (abstract, from application): Flow cytometers provide invaluable information for the fields of developmental biology, genetics, hematology, immunology, oncology, microbiology, and parasitology. Multiparameter analysis greatly enhances the capability of flow cytometers, and reducing the size, power, and cost of the laser excitation source improves thei ...

    SBIR Phase I 2001 Department of Health and Human Services
  3. HIGH PERFORMANCE DETECTOR FOR SMALL ANIMAL PET

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (Verbatim from the Applicant's Abstract): Positron Emission Tomography (PET) is an in vivo analog of autoradiography, which makes it a potentially powerful new tool for imaging biological processes in small laboratory animals. Its critical advantage is that functional data can be obtained non-invasively, allowing each animal to be studied ...

    SBIR Phase I 2001 Department of Health and Human Services
  4. N/A

    SBC: ALKERMES, INC.            Topic: N/A

    N/A

    SBIR Phase I 2001 Department of Health and Human Services
  5. Novel, sustained-release naltrexone for opiate abuse

    SBC: ALKERMES, INC.            Topic: N/A

    DESCRIPTION: While opiate agonists can be effective for treating abusers, they are. inappropriate in many circumstances. The opiate antagonist naltrexone (NTX) has been approved by the FDA and endorsed by NIDA and other government agencies as an important treatment alternative for heroin abuse. However, all authorities recognize that poor compliance greatly limits na ...

    SBIR Phase I 2001 Department of Health and Human Services
  6. Dynamic Dosimetry Planning for Ultrasound Brachytherapy

    SBC: ALPHATECH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to develop an effective ultrasound-based real-time brachytherapry treatment planning system that improves brachytherapy outcomes through better dose coverage, reduction in manual workload, and shorter treatment planning process and overall procedure duration. Our system concept incorporates innovations for: ...

    SBIR Phase I 2001 Department of Health and Human Services
  7. Substrate Profiling of New Enzymes for Drug Discovery

    SBC: ALTHEXIS COMPANY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): With a dramatic increase in the number of complete bacterial genomes in the public and private databases, there exists an outstanding opportunity for the identification of new antibacterial protein targets. Interestingly, the accumulation of genomic sequences has been punctuated by the realization that typically greater than on ...

    SBIR Phase I 2001 Department of Health and Human Services
  8. PROTEASE FORMULATION BASED ON CROSSLINKED ENZYME CRYSTAL

    SBC: ALTUS BIOLOGICS, INC.            Topic: N/A

    Design of new efficient drug delivery systems for proteins is one of the major themes of modern biotechnology and biopharmaceutical industry. We found that crosslinked enzyme crystals (CLECs(R)) show stability under low pH, on storage and against proteolysis. The CLECs can be prepared in high yield and have high protein load. These properties make them ideal for gut lumenal therapy where the thera ...

    SBIR Phase I 2001 Department of Health and Human Services
  9. NOVEL ENZYME FORMULATION FOR TREATMENT OF HYPEROXALURIA

    SBC: ALTUS BIOLOGICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Design of new efficient drug delivery systems for proteins is one of the major themes of modern biotechnology and biopharmaceutical industry. We found that crosslinked enzyme crystals (CLECs) show stability under low pH, on storage and against proteolysis. These properties make them ideal for gut lumenal therapy. The pati ...

    SBIR Phase I 2001 Department of Health and Human Services
  10. Novel In Vitro Expression Methods for Proteome Analysis

    SBC: AMBERGEN, INC            Topic: N/A

    DESCRIPTION (Applicant's abstract): Proteomic analysis is an important goal for the post-genomic era. While all genes in the human genome have now been decoded, the function of most of these genes remains undetermined. A new approach for proteomic analysis was demonstrated during Phase I based on in vitro expression and isolation of proteins. Until now, it ha ...

    SBIR Phase I 2001 Department of Health and Human Services

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