Award Data

DESCRIPTION (provided by applicant): Snapshot Image Mapping Spectrometer (IMS) for High Resolution Biological Imaging Indirect Imaging is proposing, through the SBIR funding mechanism, to develop an innovative imaging device that will allow economical snapshot hyperspectral imaging for real time microscopy and other biomedical applications, and is compatible with most research grade light microsco ...

DESCRIPTION (provided by applicant): Developmental delays are common in early childhood, affecting at least 10 percent of children and are markers for later developmental conditions. It is well established that the tremendous adaptability of the brain in the first three years of life means that early treatment of delays leads to improved outcomes, whereas later intervention is less effective. In o ...

DESCRIPTION (provided by applicant): The overall goal of this proposed research is to adopt an inexpensive IR camera and image analysis software for non-contact monitoring the breath of a premature infant. Sleep apnea in these patients can lead to significant health problems, even death. Existing sensors can give false signals. An all optical system that can detect CO2 in the baby's breath wi ...

DESCRIPTION (provided by applicant): It is estimated that around 45-60 million American women suffer from sexual disorders at some point in their lives. In comparison, about 30 million men are afflicted with comparable conditions. In both men and women, sexual disorders can be associated with a number of clinical conditions, including diabetes, heart disease, hypertension, multiple sclerosis, and ...

DESCRIPTION (provided by applicant): The long-term goal of this project is to develop accurate, rapid, high-throughput and cost-effective diagnostic tests for Fragile X syndrome (FXS) and related disorders in anticipation of population screening needs. Newborn screening (NBS) for Fragile X is timely due to the disease prevalence, lack of a clear phenotype at birth, current and emerging options for ...

DESCRIPTION (provided by applicant): NobleGen Biosciences was founded based upon the groundbreaking work of Dr. Amit Meller's lab at Boston University in which they demonstrated the proof of concept for a unique, nanopore based method for DNA sequencing bynanopore induced photon emission (SNIPE), which utilizes optical detection rather than the more ubiquitous electrical detection. The proces ...

DESCRIPTION (provided by applicant): Changes in expression have been shown to be associated with a variety of normal physiological processes as well as diseases including cancer. Studies have already shown that miRNAs may provide useful markers for the development of disease diagnostic and prognostic assays. Currently there are no discovery based, rapid-multiplexed methods available to simultaneou ...

DESCRIPTION (provided by applicant): A system is constructed for navigation feedback during an interventional cardiology procedure for Cardiac Resynchronization Therapy (CRT) by seeking out the location with low oxygen saturation, which coincidentally is the place for the implantation of leads to pace the heart. Heart failure affects 22 million people worldwide. In many of these patients, an abnor ...

DESCRIPTION (provided by applicant): Respiratory Distress Syndrome (RDS) is a life-threatening condition of the premature infant, wherein the lung is developmentally unprepared for ex utero function and rapidly develops edema, poor compliance, pulmonary arterial hypertension (PAH), and impaired gas exchange. Current standard of care is limited to low volume mechanical ventilation and the exogenou ...

DESCRIPTION (provided by applicant): The onset of hemorrhagic shock is a major cause of death in emergency departments and trauma centers. Currently there is no clinically accepted quantitative monitor of the onset of hemorrhagic shock. Death from hemorrhagic shock results from diminished capillary blood flow and the resultant failure of the body to oxygenate major organs. The long-term goal of th ...