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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Vision-QOL-CAT: A Functional Health CAT for those with Visual Disorders

    SBC: John Ware Research Group, Inc.            Topic: NEI

    DESCRIPTION (provided by applicant): With the aging of the population, vision loss is a growing public health problem affecting more than 3 million Americans. The impact of eye disease on health-related quality of life (HRQOL) and the benefits of new treatments are not well understood and have not been compared with those for other medical conditions. Although self-assessment tools for measuring t ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Advanced Laser Source for High-speed Adaptive Optics OCT

    SBC: Physical Sciences Inc.            Topic: NEI

    DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) proposes to develop a new adaptive optics imaging approach to high- speed 3D-retinal mapping with enhanced Fourier Domain Mode-locked (FDML) swept-source technology. PSI is currently engaged in ongoing development of high performance, high resolution multimodal adaptive optics (AO) retinal imagers. Such systems resolve and quant ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Long-Acting Mucus-Penetrating Steroid Particles for Treatment of Eye Inflammation

    SBC: KALA PHARMACEUTICALS, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Inadequate treatment of ocular inflammation causes severe discomfort and complications, including blindness. Current means of treating ocular inflammation cannot sustain long-term efficacy without compromising patient safety, comfort or compliance. Conventional eye drops, which are preferred over other ophthalmic and systemic dosage forms due to patient comfort ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Novel Catalyst Systems

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Transition metal catalysts are widely used in the pharmaceutical industry for the production of active ingredients, precursors and new drug candidates. These products must be very pure, often requiring labor and energyintensive separation processes, to achieve the required purity levels. Of special concern in the present context is to avoid contaminating the pr ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Methods and Instrumentation for Hydrostatic Pressure-Enhanced Tissue Fixation

    SBC: PRESSURE BIOSCIENCES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Fixation of tissue samples with formalin and paraffin is an established approach for long-term storage of tissues for later histological analyses. These formalin-fixed paraffin-embedded tissues can also be used for DNA,RNA or protein extraction for retrospective molecular studies. Unfortunately, traditional preservation methods do not guarantee uniform fixation ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Customized Nanofiltration Membranes for Enhancing Pharmaceutical Manufacturing

    SBC: COMPACT MEMBRANE SYSTEMS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): The overall focus of this application is to develop nanofiltration membranes to recover the spent solvents generated from drug manufacturing processes allowing the solvents to be reused resulting in elimination of waste. This is also responsive to NIH RFP PA-09-100 entitled Energy Efficiency and Renewable Energy System Technology Research and Development . By ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Novel Materials and Methods for Separations of Glycopeptides and Glycans

    SBC: ADVANCED MATERIALS TECHNOLOGY, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Analysis of glycoprotein polypeptide sites of carbohydrate attachment and the structures of the glycans present on these proteins requires the combination of high resolution chromatographic separations and sophisticatedmass spectrometry. Hydrophilic interaction liquid chromatography (HILIC) has great use in separations of glycopeptides and released glycans, exh ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Bifunctional Modulation of Redox Imbalance for Treatment of Septic Shock

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Sepsis accounts for gt 500K hospitalizations in the USA yearly, of which half will progress to a fatal outcome. Because there are no approved pharmaceutical agents that profoundly improve outcome, the mainstay of care is supportive administration of fluids, oxygen, mechanical ventilation, and antibiotics. Sepsis is driven by widespread tissue injury mediated by ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. A Poly(ADP-Ribose) Detection Assay Enabling Drug Discovery and Development

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Poly(ADP-ribosyl)ation is a post-translational modification that plays a central role in the regulation of cell death and DNA repair. PAR serves as a surrogate marker for poly(ADP-ribose) polymerase (PARP) and poly(ADP-ribose) glycohydrolase (PARG), which are being actively pursued as therapeutic targets with several PARP inhibitors already in clinical trials. ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Improving self delivering properties of RNAi compounds through medicinal chemistr

    SBC: RXI PHARMACEUTICALS CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in potent and specific gene silencing by RNA interference (RNAi). Unfortunately, while siRNA-based drugs represent a potentially significant therapeutic paradigm, the ability to apply this technology to human disease has been impeded by the absence of efficient and non ...

    SBIR Phase I 2011 Department of Health and Human Services

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