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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Value Added Product Generation from ARD

    SBC: BLUE PLANET STRATEGIES, LLC            Topic: NIEHS

    DESCRIPTION (provided by applicant): Harmful metals not readily detoxified naturally are discharged from numerous industrial activities and pose lasting environmental hazards requiring expensive remediation efforts. This project targets profitable dilute metal removal and reclamation. Creating an economic driver for metal contamination mitigation improves human health by promoting environmental cl ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. Enhanced endophyte:poplar system for remediation of organic contaminants

    SBC: Edenspace Systems Corporation            Topic: NIEHS

    DESCRIPTION (provided by applicant): Trichloroethylene (TCE), one of the most common groundwater pollutants, is a known hepatotoxin and carcinogen. It has been widely used by industry and the military as a degreaser for metal parts: according to the Agencyfor Toxic Substances and Disease Registry, more than eight hundred Superfund sites in the United States are contaminated with TCE. Poplar, which ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Develop and Test an Online Biohazard Simulator to Train Skilled Support Personnel

    SBC: GRYPHON SCIENTIFIC, LLC            Topic: NIEHS

    DESCRIPTION (provided by applicant): The World Trade Center clean-up focused national attention on the inadequate training for skilled support personnel , OSHA's term for workers in trades (including construction, demolition and transportation) deployed to support disaster response (Lippy and Murray, 2003). While the relevant OSHA standard (29CFR 1910.120) provides detailed training for emer ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. Prevention of Retinopathy of Prematurity with a Novel Bifunctional Redox Reagent

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Retinopathy of prematurity (ROP) is present in up to 70-85% of very low birthweight premature infants (lt 1 kg). The more severe forms of ROP (Grades 3-5) account for more than 50% of injuries and are associated with lifelong visual impairment, including blindness. There are no pharmaceutical agents, or other measures, approved for the prevention of ROP. A ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Vision-QOL-CAT: A Functional Health CAT for those with Visual Disorders

    SBC: John Ware Research Group, Inc.            Topic: NEI

    DESCRIPTION (provided by applicant): With the aging of the population, vision loss is a growing public health problem affecting more than 3 million Americans. The impact of eye disease on health-related quality of life (HRQOL) and the benefits of new treatments are not well understood and have not been compared with those for other medical conditions. Although self-assessment tools for measuring t ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Advanced Laser Source for High-speed Adaptive Optics OCT

    SBC: Physical Sciences Inc.            Topic: NEI

    DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI) proposes to develop a new adaptive optics imaging approach to high- speed 3D-retinal mapping with enhanced Fourier Domain Mode-locked (FDML) swept-source technology. PSI is currently engaged in ongoing development of high performance, high resolution multimodal adaptive optics (AO) retinal imagers. Such systems resolve and quant ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Long-Acting Mucus-Penetrating Steroid Particles for Treatment of Eye Inflammation

    SBC: KALA PHARMACEUTICALS, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Inadequate treatment of ocular inflammation causes severe discomfort and complications, including blindness. Current means of treating ocular inflammation cannot sustain long-term efficacy without compromising patient safety, comfort or compliance. Conventional eye drops, which are preferred over other ophthalmic and systemic dosage forms due to patient comfort ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Methods and Instrumentation for Hydrostatic Pressure-Enhanced Tissue Fixation

    SBC: PRESSURE BIOSCIENCES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Fixation of tissue samples with formalin and paraffin is an established approach for long-term storage of tissues for later histological analyses. These formalin-fixed paraffin-embedded tissues can also be used for DNA,RNA or protein extraction for retrospective molecular studies. Unfortunately, traditional preservation methods do not guarantee uniform fixation ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. Bifunctional Modulation of Redox Imbalance for Treatment of Septic Shock

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Sepsis accounts for gt 500K hospitalizations in the USA yearly, of which half will progress to a fatal outcome. Because there are no approved pharmaceutical agents that profoundly improve outcome, the mainstay of care is supportive administration of fluids, oxygen, mechanical ventilation, and antibiotics. Sepsis is driven by widespread tissue injury mediated by ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Improving self delivering properties of RNAi compounds through medicinal chemistr

    SBC: RXI PHARMACEUTICALS CORPORATION            Topic: NIGMS

    DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in potent and specific gene silencing by RNA interference (RNAi). Unfortunately, while siRNA-based drugs represent a potentially significant therapeutic paradigm, the ability to apply this technology to human disease has been impeded by the absence of efficient and non ...

    SBIR Phase I 2011 Department of Health and Human Services

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