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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ASSAYS FOR HEPATITIS B VIRUS WITH HUMAN LEUKEMIC CELL LINES

    SBC: CBR LABORATORIES, INC.            Topic: N/A

    INFECTION OF HUMANS WITH THE SMALL HEPATOTROPHIC DNA VIRUS, HEPATITIS B VIRUS (HBV), CAN LEAD TO ACUTE OR CHRONIC HEPATITIS, CIRRHOSIS AND PRIMARY HEPATOCELLULAR CARCINOMA. IN SPITE OF ADVANCES IN TESTING OF BLOOD AND THE RECENT INTRODUCTION OF A SAFE EFFECTIVE VACCINE, THERE IS STILL AN INCIDENCE OF ABOUT 6% INFECTION BY HBV IN INDIVIDUALS WHO RECEIVE A BLOOD TRANSFUSION OR BLOOD PRODUCTS. THUS T ...

    SBIR Phase I 1988 Department of Health and Human Services
  2. CRYOPRESERVATION OF PANCREATIC ISLET CELLS

    SBC: Cellular Transplantation            Topic: N/A

    DIABETES MELLITUS IS ONE OF THE MOST PREVALENT, MORBID AND MORTAL DISEASES KNOWN TO MANKIND. TRANSPLANTATION OF PANCREATIC ISLETS IN ANIMAL MODELS CAN COMPLETELY CURE DIABETES AND MORE IMPORTANTLY MAKE THE ANIMAL ABSOLUTELY INDEPENDENT OF INSULIN. THE SUCCESSFUL TRANSPLANTATION OF ISLETS CAN BE FACILITATED IN A CLINICAL SITUATION IF ADEQUATE MEANS OF PRESERVING ISLETS ARE AVAILABLE. THE OVERALL LO ...

    SBIR Phase I 1988 Department of Health and Human Services
  3. SYNTHESIS OF FLUORESCENT INDICATORS FOR CYTOSOLIC CA2+

    SBC: COVALENT ASSOC., INC.            Topic: N/A

    A SERIES OF IMPROVED FLUORESCENT DYES SPECIFIC FOR COMPLEXING CA2+ WILL BE SYNTHESIZED AND EVALUATED FOR THEIR ABSORPTION AND EMISSION CHARACTERISTICS AND THEIR ABILITY TOBIND CA2+. THESE CHELATORS INCORPORATE BENZOCOUMARIN LASER DYE FLUOROPHORES, WHICH HAVE DESIRABLE HIGH-QUANTUM YIELDS AND VISIBLE WAVELENGTH ABSORPTION AND EMISSION. THE FLUOROPHORE IS ATTACHED TO AN EGTA-LIKE (ETHYLENEGLYCOL BIS ...

    SBIR Phase II 1988 Department of Health and Human Services
  4. SOFTWARE FOR GROUP-SEQUENTIAL CANCER CLINICAL TRIALS

    SBC: CYTEL SOFTWARE CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  5. ARTICULATION TRAINING AID

    SBC: Design Automation Associates            Topic: N/A

    A CONCEPT HAS BEEN DEVISED FOR THE APPLICATION OF MODERN SPEECH-RECOGNITION TECHNIQUES TO ASSIST IN ARTICULATION TRAINING OF PERSONS WITH SPEECH DEFICITS OR RELATED LEARNINGDISABILITIES. PROPOSED IS A DEVELOPMENT EFFORT TO EMBODY THE CONCEPT IN SOFTWARE AND ADD-ON HARDWARE FOR A PERSONAL COMPUTER TERMINAL. IT IS EXPECTED THAT THIS TRAINING AID WOULD BE UTILIZED AT FIRST, AT SPEECH AND LANGUAGE CLI ...

    SBIR Phase I 1988 Department of Health and Human Services
  6. A STRABISMUS CORRECTING PROSTHESIS

    SBC: Dsp Engineering Inc            Topic: N/A

    TREATMENT OF STRABISMUS REMAINS A SIGNIFICANT CHALLENGE TO THE FIELD OF OPHTHALMOLOGY. A NEW APPROACH HAS BEEN TAKEN TO TREAT THIS CONDITION WHICH PROVIDES A LEVEL OF PRECISION AND FLEXIBILITY UNOBTAINABLE VIA SURGICAL AND/OR PHARMOCOLOGICAL MEANS. THE WELL-ESTABLISHED TECHNIQUE OF ELECTRICAL STIMULATION TO PRODUCE CONTROLLED MUSCLE CONTRACTION HAS BEEN EMPLOYED IN A NOVEL WAY. A PROSTHESIS SYSTEM ...

    SBIR Phase I 1988 Department of Health and Human Services
  7. TELEPHONE COMMUNICATION FOR THE DEAF

    SBC: Duffy Engineering            Topic: N/A

    THIS PROPOSAL ADDRESSES THE PROBLEM OF TELEPHONE COMMUNICATION BY THE DEAF AND DEAF-BLIND. THE CURRENT STATE OF THE ART ALLOWS THESE PERSONS TO COMMUNICATE ON THE TELEPHONE WITH OTHERS WHEN BOTH ARE USING SPECIALIZED EQUIPMENT. THE PROPOSED CONCEPT WOULD REQUIRE SPECIALIZED EQUIPMENT BY THE HEARING-IMPAIRED PERSON ONLY. THE PROCESS IS BASED ON A COMMERCIAL MICROCOMPUTER CONVERTING TONE OR PULSE SI ...

    SBIR Phase II 1988 Department of Health and Human Services
  8. IMPROVED ACCURACY IN MANUAL BLOOD PRESSURE MEASUREMENTS

    SBC: Dynamedics Inc            Topic: N/A

    EFFORTS TO REDUCE MEASUREMENT VARIATION AND OBSERVER ERROR IN BLOOD PRESSURE MEASUREMENTS HAVE MET WITH SOME SUCCESS INRESEARCH AND INSTITUTIONAL ENVIRONMENTS. HOWEVER, THESE EFFORTS, WHICH INCLUDE THE RANDOM-ZERO SPHYGMOMANOMETER, THEZERO MUDDLER, AND AUTOMATED SPHYGMOMANOMETERS, HAVE GENERALLY NOT BEEN SUITABLE IN PROFESSIONAL AND OFFICE-BASEDCLINICAL APPLICATIONS WHERE MOST BLOOD PRESSURE MEASU ...

    SBIR Phase I 1988 Department of Health and Human Services
  9. DEVELOPMENT OF A THIN CERAMIC COATING FOR IMPLANTED DEVICE PROTECTION

    SBC: ECO ENERGY CONVERSION            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  10. DEVELOPMENT OF A NEW DOSAGE FORM FOR LONG-TERM STUDIES OF ^9-THC

    SBC: ElSohly Laboratories, Incorporated            Topic: N/A

    STUDIES IN THIS PROPOSAL WILL BE AIMED AT THE PREPARATION OFA SUPPOSITORY FORMULATION OF A PRO-DRUG OF DELTA-9-TETRA- HYDROCANNABINOL (^9-THC) AND STUDY THE BIOAVAILABILITY OF THC FROM THIS FORMULATION AS COMPARED TO I.V. ADMINISTRATIONOF BOTH THC AND ITS PRODRUG. BIOAVAILABILITY STUDIES WILL BE CONDUCTED IN MONKEYS, AND BLOOD SAMPLES WILL BE COLLECTEDAT 0, 15, 30, 60, 90, 120, 180, 240, AND 480 M ...

    SBIR Phase II 1988 Department of Health and Human Services

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