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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Low Cost Co-Doped Scintillator for Medical CT

    SBC: Radiation Monitoring Devices, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Venous catheters play critical roles in the administration of chemotherapy, antibiotics, blood, blood products and total parenteral nutrition essential for the successful treatment of many chronic afflictions. Recent ad vances in catheter technology have enabled the explosive growth in oncology (vascular access ports), nephrology (hemodialysis catheters) and in ...

    SBIR Phase II 2008 Department of Health and Human Services
  2. Production and use of Pb-203 for cancer therapy research

    SBC: ALPHAMED, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Promising results are being obtained from studies of molecules labeled with Lead-212 (Pb-212) as potential targeted radiotherapeutic agent against metastatic melanoma. According to the American Cancer Society approximat ely 60,000 people in the US will be diagnosed with melanoma this year, and 8,000 will die from this disease. For Pb-212 melanoma therapy to pro ...

    SBIR Phase II 2008 Department of Health and Human Services
  3. ADVANCED TECHNOLOGY FOR ASSAYING CANCER-DRUG RESISTANCE

    SBC: AMBERGEN, INC            Topic: N/A

    DESCRIPTION (provided by applicant): Significant advances have been made toward the development of a new generation of molecularly targeted cancer drugs, many of which are only now emerging from the pipeline. This project aims to develop a new, highly sens itive technology for detecting drug-resistance mutations in proteins which preexist prior to treatment or are acquired due to the selective pre ...

    SBIR Phase II 2008 Department of Health and Human Services
  4. D9-THC for Marijuana Addiction

    SBC: APHIOS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): ?9-tetrahydrocannabinol (?9-THC) has been shown to alleviate marijuana withdrawal symptoms and thus has potential for treating cannabinoid dependence. However, the bioavailability of ?9-THC administered orally is poor a nd variable. In addition, it also requires drug administration several times a day. Formulations to improve bioavailability and/or to reduce do ...

    SBIR Phase I 2008 Department of Health and Human Services
  5. 402- RFP: N43-CM-87007-68 TOPIC 251: DEVELOPMENT OF ANTICANCER AGENTS REQUEST

    SBC: APHIOS CORPORATION            Topic: N/A

    The aim of this project is the development of Tyrosyl DNA phosphodiesterase (Tdp1) inhibitors in order to enhance the activity of DNA topoisomerase I inhibitors.

    SBIR Phase I 2008 Department of Health and Human Services
  6. THERAPY AGAINST RECALCITRANT C. albicans INFECTION

    SBC: Arietis Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of this project is to develop an effective therapy against relapsing vaginosis caused by Candida albicans. The disease occurs in 8-9% of all women, and is recalcitrant to currently available therapies . Upon adherence to a surface, C. albicans forms persister cells which are tolerant to currently available antimicrobials. Known compounds alon ...

    SBIR Phase I 2008 Department of Health and Human Services
  7. Antibody therapeutics- feasibility study on hormone-refrectory prostate cancer m

    SBC: ATTOGEN, INC            Topic: N/A

    DESCRIPTION (provided by applicant): We propose to evaluate the therapeutic feasibility of a humanized antibody drug DAPI- 01 (anti-FGFR2-IIIc) in prostate cancer model systems. The molecular target of the antibody is fibroblast growth factor receptor-2 (F GFR2) isoform IIIc, which is involved in androgen-independent tumor growth and metastasis. Our specialized antibody drug is designed with the i ...

    SBIR Phase I 2008 Department of Health and Human Services
  8. Lateral flow assay for detecting colonization by Streptococcus agalactiae

    SBC: BIOHELIX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Streptococcus agalactiae, a.k.a. group B streptococcus (GBS), is one of the leading causes of morbidity, and mortality among newborns. We propose to develop a molecular assay for GBS using our proprietary helicase depe ndent amplification (HDA), and a lateral flow strip embedded in a device that encloses the reaction vessel to prevent contamination of the labo ...

    SBIR Phase I 2008 Department of Health and Human Services
  9. Development of a novel whole genome amplification method that mimics nature

    SBC: BIOHELIX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): BioHelix is the exclusive licensee for a novel, primase-based Whole Genome Amplification (pWGA) technology invented by Drs. Stanley Tabor and Charles Richardson at Harvard Medical School. This pWGA system utilizes multi ple replication proteins including a primase/helicase, a DNA polymerase, a single-stranded DNA binding protein, and several other accessory pro ...

    SBIR Phase II 2008 Department of Health and Human Services
  10. Herpes virus typing assay for detecting genital herpes

    SBC: BIOHELIX CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of our NIAID Biodefense Phase I SBIR program was to develop, and commercialize field deployable nucleic acid analysis devices for use in biodefense applications. We have begun to sell IsoAmp II kits that will allow our clients to develop home brew assays (we list customers in the commercialization plan). For example, the LANL has obtained NIH fu ...

    SBIR Phase II 2008 Department of Health and Human Services

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