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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Efficacy and Safety of an Aerosolized Recombinant Butyrylcholinesterase Pretreatm

    SBC: Extend Biosciences Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): Cachexia is a complex syndrome characterized by involuntary weight loss and skeletal muscle wasting that leads to fatigue, weakness and a loss of appetite that is not reversed by increased caloric consumption. More thanhalf of all cancer patients develop cachexia and it is responsible for more than 40% of all cancer deaths. Numerous complications associated wit ...

    SBIR Phase I 2013 Department of Health and Human Services
  2. Naloxone Nasal Spray Development

    SBC: IMMUNEXCITE, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): The introduction of therapeutic monoclonal antibodies (mAbs) in cancer has come of age with mAbs now approved for various cancer types including breast cancer. Unmodified mAbs tend to have moderate efficacy in eliminating metastatic tumors even when combined with chemotherapeutic agents. Drug/Toxin mAb conjugates may bring additional clinical benefit but are ex ...

    SBIR Phase I 2013 Department of Health and Human Services
  3. Blocking a novel cytokine signaling pathway for the treatment of rheumatoid arthr

    SBC: Axios Biosciences, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): This Small Business Innovation Research (SBIR) Phase I application is in response to Funding Opportunity Announcement PA-12-088. Tumor-stromal interactions are increasingly recognized as critical components of the progression of human neoplasias, including tumor invasion and metastasis. Utilizing a novel high- throughput screening approach developed by the appl ...

    SBIR Phase I 2013 Department of Health and Human Services
  4. Vaginal Tactile Imager for Pelvic Floor Biomechanical Assessment

    SBC: Organix Incorporated            Topic: NIDA

    DESCRIPTION (provided by applicant): Chronic pain can result from various disease conditions and about 45% of the U. S. population seeks medical help for treatment of pain. Neuropathic pain is a type of chronic pain which is very difficult to treat, and most patients do not get adequate relief. A promising therapeutic drug target for the treatment of inflammation and pain is the cannabinoid CB2 re ...

    SBIR Phase I 2013 Department of Health and Human Services
  5. DEVELOPMENT OF PHYSIOLOGICALLY INSPIRED SIGNAL PROCESSING STRATEGIES FOR COCHLEAR

    SBC: Sensimetrics Corporation            Topic: NIDCD

    DESCRIPTION (provided by applicant): Cochlear implants (CI) are neural prostheses that provide meaningful auditory experience to more than 200,000 deaf patients worldwide. Despite significant success in quiet listening conditions, CIs currently provide only limited benefit in nosy real world situations. A critical limitation of the signal processing strategies employed by curren CIs is that they p ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. Confirmatory Screening for Congenital Non-Syndromic Genetic Hearing Loss Using Ta

    SBC: Focused Genomics dba Parabase Genomics            Topic: NIDCD

    DESCRIPTION (provided by applicant): Approximately 8,000 children in the USA are born each year with some form of hearing loss severe enough to require special services. Half of these are genetic in origin covering several hundred different regions in thegenome where mutations affect the hearing process. One example of genetic predisposition makes some people more likely to develop hearing loss af ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. A Synthetic Biology Toolbox for Natural Product Discovery from Actinomycetes

    SBC: Spire Corporation            Topic: NIDCR

    DESCRIPTION (provided by applicant): The incidence of traumatic facial injuries relative to injuries at the other anatomic locations has risen sharply during combat operations in Iraq and Afghanistan compared to previous military conflicts. Evan in the civilian population, traumatic craniofacial bone injury is often accompanied by injury or loss of surrounding soft tissues. There are reports of l ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. Advanced software tools for planning the placement of skeletal fixation hardware

    SBC: Physical Sciences Inc.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Physical Sciences Inc. and its collaborators at Medical Modeling Inc. and the Brigham and Women's hospital propose to develop software for planning maxillofacial surgery. The software will complement the OsteoMark system under development at PSI and will be integrated with the current surgical planning process used by many surgeons. Current software for p ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Simplifying encoding of bioassays to accelerate translational drug discovery

    SBC: Physical Sciences Inc.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Physical Sciences, Inc. (PSI), in collaboration with The Forsyth Institute, Cambridge, MA proposes to investigate the use of combined Raman microspectroscopy-Optical Coherence Tomography (OCT) imaging for in vivo diagnosis of tooth decay, cracks, and periodontal diseases. Both Raman and OCT are powerful technologies with proven success in human tissue diagnosis ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. KIDNEY STONE INHIBITORS

    SBC: ICET, INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Urolithiasis is a worldwide problem. The lifetime prevalence of urolithiasis is 13% for men and 7% for women in the U.S (NIDDK) and an estimated 2.1 billion was spent in claims for diagnosis for urolithiasis in 2000 which was 50% more than 1994 (Pearle, 2005). Up to 50% of patients may have recurrence within 5 years. (Asplin et al., 1996). Stones injure kidney ...

    SBIR Phase I 2013 Department of Health and Human Services

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