Award Data

DESCRIPTION (provided by applicant): This Phase I SBIR application is presented by Aeris Therapeutics, Inc. of Woburn, MA. It will examine the feasibility of using a novel enzyme based-system to produce safe, clinically-effective pleurodesis for treatment of malignant pleural effusions. Preliminary data, summarized in this application, suggest that an enzymatic system has the potential for bei ...

75422B The increase of atmospheric CO2 from fossil fuel combustion is a major contributor to global warming and climate change. Improved measurement technology for directly determining the exchange fluxes of the stable isotopes of CO2 is crucial to understanding the natural carbon cycle, which transforms atmospheric CO2 into biological carbon, and to develop strategies to mitigate the problem. ...

75716S Aerosol particles in the atmosphere have important effects on visibility, acid deposition, climate, and human health. A significant amount of anthropogenic aerosols is generated from energy-related activities, and organic compounds are known to constitute a significant fraction of ambient aerosol mass in many locations. However, there is a lack of are real-time, size-resolved, quantitati ...

This Small Business Innovation Research Phase II project addresses the need for improved monitoring technologies for continuous particulate mass and chemical speciation of ambient aerosols. Aerodyne Research, Inc. will develop a prototype Aerosol Chemical Speciation Monitor (ACMS) that measures ambient aerosol mass and chemical composition of non-refractory submicron aerosol particles in real-tim ...

79105S05 As plasma modeling and simulation become mature, virtual diagnostics can become an option for tokamak research in the fusion energy program. A virtual diagnostics toolset that allows direct comparison of numerical simulation with tokamak measurements would provide an invaluable tool for thorough understanding of tokamak plasmas and further define future necessary diagnostics. This proje ...

79508S05 Aerosol particles have important effects on visibility, acid deposition, climate, and human health. A large fraction of the anthropogenic aerosol is generated from energy-related activities, and organic compounds are known to constitute a significant fraction of ambient aerosol mass in many locations. Yet, large uncertainties remain in quantifying the chemical composition and atmospheri ...

Hydrogen peroxide formation represents a loss of gas phase HOx and results in the transfer of atmospheric oxidative capacity to the liquid phase. Measurements of formaldehyde and H2O2 are vital to fully elucidate the atmospheric mechanisms associated with ozone formation and the formation of inorganic and secondary organic aerosol throughout the atmosphere. Tunable infrared differential absorpti ...

An important and fundamental challenge in science and engineering is the need to understand the system output variables (model predictions, measured observables) and their relation to the system¡¦s input variables (model inputs, specified experimental conditions). This project proposes to address this problem through the development of a family of numerical tools for implementing High Dimension ...

DESCRIPTION (provided by applicant): The analysis of components in human breath is a powerful non-invasive technique for the diagnosis and monitoring of asthma, cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). The presence of elevated levels of nitric oxide (NO), carbon monoxide (CO), and ethane (C2H6) in the breath have been identified as biomarkers of these diseases, wh ...

The USDA recognizes the need for improved instrumentation to monitor atmospheric ammonia which is a major environmental concern and a health hazard. Ammonia is a public health concern at high levels, as can be found in animal feed lots. At low levels, ammonia is a source of particulates which are not only a human health problem but also affect visibility and global climate. It has been estimated t ...