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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. FAST platform for same-shift, complete antibiotic menu antibiotic susceptibility testing

    SBC: SeLux Diagnostics            Topic: R

    The goal of this Phase I SBIR proposal is to demonstrate utility to all major pathogenic bacterial strains of SeLux s rapidlow costphenotypic antibiotic susceptibility testASTsystemfast AST or FASTUtilizing existing optical detectors and standard dried antibiotic microplatesand avoiding pitfalls of metabolic probesFAST will potentially transform therapy of infections by significantly accelerating ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Humanized Anti-Renalase Antibodies for Unresectable Melanoma

    SBC: BESSOR PHARMA, LLC            Topic: 102

    Project Summary AbstractThis project brings together an experiencedintegrated project team with complementary expertise to advance a new approach to treating melanomas that cannot cured by surgery and have spread in the bodyThe project attacks a new targetrenalasean endogenous protein that can function as a survival factorwhich becomes overexpressed in melanomaand plays a role in suppressing the b ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Interventions to Improve Reproductive Health among Adolescents

    SBC: DFusion            Topic: NICHD

    Althoughyear olds are onlyof the U Ssexually active populationthey account for nearlyof themillion new cases of sexually transmitted infectionsSTIeach yearAlthough historically lowthe U Steen pregnancy rate continues to be one of the highest in the developed worldEvidence based prevention efforts can help avoid the costs and health consequences associated with STIs and unwanted teen pregnancy amon ...

    STTR Phase I 2018 Department of Health and Human Services
  4. Culture-free identification of pathogens common in endocarditis directly from patient specimens

    SBC: HELIXBIND INC.            Topic: NIAID

    PROJECT SUMMARY Infective EndocarditisIEis a life threatening disease that affects roughlyAmericans annuallyIE is characterized by microbial vegetations on the endocardial surface which induce serious heart damage and persistent bloodstream infectionsBSIsleading to sepsisLeft untreated IE is fatalAmong the criteria to establish IE and treat patients most effectivelyblood cultures are indispensable ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. CFI Pathogen Inactivation of Human Plasma Units

    SBC: APHIOS CORPORATION            Topic: NHLBI

    PROJECT SUMMARY The rapid spread of the Zika viruswhich can have a significant impact on neurological disorders in unborn fetuses and potentially adultsthe recent outbreak of the extremely virulent Ebola virusperiodic emergence of SARSrecurrent outbreaks of potentially pandemic strains of influenza such as H Nthe continuing epidemic of MERS and the worldwide AIDS epidemic have highlighted a persis ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Aerosol Delivery of Surfactant for ARDS

    SBC: KAER BIOTHERAPEUTICS CORPORATION            Topic: NHLBI

    Acute respiratory distress syndromeARDSafflicts aboutAmericans each yearThe pathology consists of rapid onset of respiratory symptoms including radiographic bilateral opacities and pulmonary edemaThe primary risk factors for the development of ARDS are pneumoniaaspirationmajor traumasepsisand inhalation injuryDespite the adoption of lung protective ventilationthe mortality rate remains aboutCommon ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Head mounted smartphone system for remote treatment of convergence insufficiency

    SBC: EYEPHONE LLC            Topic: NEI

    PROJECT SUMMARYIn this projectwe propose to develop and demonstrate feasibility of a head mounted smartphone based application forin home training and remote monitoring of progress for patients with convergence insufficiencyCICI develops in anestimatedofschool agechildrenintheU Soverallandcausessymptomsofeyestrainblurredvisionand reduced concentrationresulting in significant educational disadvanta ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Oxygen-Generating Dressing

    SBC: Theracell, Inc.            Topic: 600

    EquipmentThe equipment currently available at TheraCell includesBarnstead Reverse Osmosis Water Purification System Compressed Air system Laminar Flow Hood Fume Hood Oxygen plasma chamber Vacuum pumpsdry and oil Ultrasonic cleaner Laboratory balances Convection oven Forced Convection Oven Nuaire Incubator Vacuum oven Small autoclave Large volume cooled centrifuge with swing out rotor and buckets I ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Inhibitors of virus glycoprotein-LAMP1 receptor binding for Lassa virus therapy

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    Summary Since its discovery inLassa virusLASVa bi segmented RNA virus from the family Arenaviridaehas been recognized as the cause of disease affecting a quarter million people per yearresulting indeaths annually in West AfricaDue to global travelthere have been numerous confirmed cases of LASV infection outside West Africa including the USIts ability to spread as an aerosol and a case fatality ra ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Retinal eye-tracking for the prognosis and monitoring of multiple sclerosis

    SBC: C. Light Technologies, Inc.            Topic: NINDS

    Abstract The goal of this project is to validate an innovativehighly sensitive retinal eye tracking technologythe tracking scanning laser ophthalmoscopeTSLOas a prognostic and monitoring tool for neurodegenerative disordersnamely multiple sclerosisMSThe applications of effective treatments for multiple sclerosis are constrained bythe absence of methods for early detection andquantitativehighly sen ...

    STTR Phase I 2018 Department of Health and Human Services

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