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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Inhibition of Cardiac Device Induced Cellular Dysfunction in Pigs

    SBC: Novelmed Therapeutics Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): Artificial surfaces of cardiac devices induce cellular activation and platelet dysfunction in patients undergoing bypass procedure. While other pathways may be activated during this process, alternative pathway (AP) activation appears to be one of the important mechanisms for cellular activation and platelet dysfunction in the whole blood model of biomaterial s ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Disease Modifying Biologics for Rheumatoid Arthritis

    SBC: Novelmed Therapeutics Inc            Topic: NIA

    DESCRIPTION (provided by applicant): Nearly 70 million people in the US suffer from arthritis related conditions[1, 2]. Of these, rheumatoid arthritis (RA) cases constitute approximately 3 million. RA is a chronic systemic inflammatory disease that primarily results in erosive destruction of articular joints with additional variable extra-articular effects. The growing elderly population coupl ...

    SBIR Phase I 2010 Department of Health and Human Services
  3. Y2 and Y4 Agonists in Obesity

    SBC: P2D, INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): The purpose of the proposed studies is to assess the feasibility of developing a novel Neuropeptide Y (NPY) obesity treatment. Extensive preclinical and clinical studies indicate that NPY receptors are important mediators of appetite and obesity. The proposed Specific Aims will determine if chronic treatment with selective NPY Y2 or Y4 receptor agonists demonst ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. PD2024: A Peripherally Active TNFalpha inhibitor for the treatment of Obesity

    SBC: P2D, INC            Topic: NIDDK

    DESCRIPTION (provided by applicant): The purpose of the proposed SBIR Phase 1 feasibility study is to assess the efficacy of our lead tumor necrosis factor- alpha (TNF1) inhibitor for the treatment of obesity. Two-thirds of U.S. adults are obese or overweight according to NIH statistics published in 2006. In addition to increased mortality observed in obesity, it is estimated that 70% of cardiovas ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. RAPID QUANTITATIVE POINT OF CARE TEST FOR NICOTINE METABOLITE

    SBC: SILOAM BIOSCIENCES            Topic: NIDA

    The goal of this fast-track SBIR project is to develop the first ever, point-if-care test (POCT) to determine the ratio of nicotine metabolites

    SBIR Phase I 2010 Department of Health and Human Services
  6. New In Vitro Human Liver Toxicity Bioassay System

    SBC: Vivo Biosciences Inc            Topic: NIEHS

    DESCRIPTION (provided by applicant): Abstract: The overall goal of this SBIR proposal is to develop and commercialize a new human liver bioassay system for real time, long-term toxicity analysis of chemical agents or drugs in vitro. At present, liver studies are mostly performed using hepatocytes cultured onto synthetic or animal-derived matrices. Unfortunately these models fail to replicate true ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. PURIFICATION, REFORMULATION AND PHARMACOKINETICS OF NITROSYLCO

    SBC: BNOAT ONCOLOGY, INC.            Topic: NCI

    Oncology remains a major market of unmet need. BNOAT Oncology¿s long-term objective is New Drug Approval of its lead candidate nitrosylcobalamin, a tumor-specific, apoptosis-inducing, anti-cancer drug. Research Design and Methods: Nitrosylcobalamin purification will include crystallizations, various chromatographic techniques including basic ion-exchange resins, neutral ion exchange, gel filtrati ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Preclinical Development of JS-K, a Novel NO-Generating Prodrug for Cancer

    SBC: JSK THERAPEUTICS INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Despite notable achievements over the past two decades, cancer remains a challenging 21st century epidemic demanding new, more effective drugs. Nitric oxide (NO) is well known to kill cancer cells without harming normal bone marrow cells, but until now has not been used directly to treat cancer because of its effect to lower blood pressure. JSK Therapeutics (J ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. High-fidelity clinical movement analysis with body mounted sensors

    SBC: ORCHARD KINETICS, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): High-fidelity clinical movement analysis with body mounted sensors Summary Clinical movement analysis is an important tool for management of orthopedic and neurological movement disorders. Despite scientific and clinical successes, this tool has not found widespread use in clinical practice outside of major research centers. One reason for this is the high cos ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. A Parylene Ribbon Cable for Neural Prosthetic Applications

    SBC: BLACKROCK MICROSYSTEMS            Topic: NIDCD

    DESCRIPTION (provided by applicant): This project addresses the process development and evaluation of an extremely flexible, Parylene C, micro-ribbon cable that is both biocompatible and biostable. Such a cable would be employed to link micro-electrode arrays with percutaneous connectors as well as with other in vivo micro-electronic arrays and modules. The key innovation is the approach utilized ...

    SBIR Phase I 2010 Department of Health and Human Services

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