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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development and testing of MRI mediated radiofrequency ablation system and probes

    SBC: Robin Medical, Inc.            Topic: NCI

    Project Summary Abstract Radiofrequency ablation RFA is a minimally invasive method used to treat solid tumors commonly primary liver cancers and metastases which are accessible percutaneously via a sharp needle Imaging guidance typically by ultrasound or CT is required for probe placement but these methods are incapable of monitoring the progress of the procedure Additional imaging sessi ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Development of VLP vaccine for RSV

    SBC: SIGMOVIR BIOSYSTEMS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Respiratory syncytial virus RSV is a substantial threat to human health most severely affecting three large populations infants young children and the elderly Despite the significance of RSV disease in these different populations there are no vaccines available The goal of this Phase II STTR project is to continue preclinical testing of a novel RSV vac ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Genetic Cytology for Ovarian and Endometrial Cancer Screening

    SBC: PAPGENE, INC.            Topic: 102

    DESCRIPTION provided by applicant In this Fast Track application a path to commercialization will be pursued for a breakthrough andquot genetic cytologyandquot test capable of detecting both ovarian and endometrial cancer from routinely collected Pap specimens In deference to the notable success of the Pap test in reducing deaths due to cervical cancer and in reference to the core enabling ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Multivalent Oral Vaccine against Enterotoxigenic Escherichia coli and Enteric Fevers

    SBC: PROTEIN POTENTIAL LLC            Topic: NIAID

    Enteric diseases caused by enterotoxigenic E coli ETEC strains Shigella spp and Salmonella Typhi all of which are NIAID Category B priority agents collectively affect andgt million people annually worldwide Currently there is no vaccine against ETEC or shigellosis A typhoid vaccine exists An affordable effective oral multivalent vaccine against all organisms would have enormous ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Technology to Select Candidates for Prophylactic Treatments to Prevent Sporadic Breast Cancers

    SBC: SILBIOTECH, INC.            Topic: 102

    PROJECT SUMMARY ABSTRACT This SBIR direct Phase II project is on developing a multimarker based technology for precisely selecting candidates for prophylactic treatments and preventing sporadic breast cancers The patient population addressed here for selecting candidates is among subjects diagnosed with proliferative precancerous breast tumors that include atypias papillomas sclerosing adenos ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Plant derived HIV neutralizing mAbs for passive immunotherapy in newborn macaques

    SBC: Plant Vax, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant The identification of highly potent broadly neutralizing antibodies bnAbs against HIV and success in preventing SHIV infection following their passive administration have increased the likelihood that immunotherapeutic strategies can be adopted to prevent and treat HIV infection However while broad and potent neutralizing activity is an essential prer ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Novel Mucosal Adjuvant for an HIV DNA Vaccine

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Our primary approach to develop an effective prophylactic vaccine against HIV utilizes a novel immunogen called the Full Length Single Chain FLSC that consists of gp derived from HIV genetically linked via a amino acid linker to the D D domains of human CD When rhesus macaques were inoculated with versions of FLSC that contain CD derived from rhes ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. In Vivo Efficacy Studies of Clofazimine against CDAD in Hamster Model

    SBC: KAMTEK INC            Topic: NIAID

    DESCRIPTION provided by applicant CDC identified in a report C difficile CD associated disease CDAD as andquot urgent public health threatandquot responsible for at least deaths annually A primary factor for origin of CDAD is exposure to broad spectrum antibiotics causing a disruption of normal intestinal bacterial flora unchecked growth of CD and its toxins causing serious i ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Multi Source E Beam kV X Ray Tube for Image Guided Radiotheraphy

    SBC: TELESECURITY SCIENCES, INC.            Topic: 102

    DESCRIPTION provided by applicant This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice The key novel technology is an optimized multi source X ray tube with focal spots that is placed below the multi leaf collimator MLC of a r ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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