Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of streamlined chemoenzymatic glycan remodeling systems for antibodies and other important glycoproteins

    SBC: Glycot Therapeutics, LLC            Topic: 300

    Project abstract summary This proposal responds to the NIH PANew Technologies for the GlycosciencesRRWe aim to develop efficient and streamlined cheomoenzymatic systems for glycan remodeling of antibodies and other important glycoproteinsthrough optimizing enzyme immobilization and simplifying the reaction proceduresSuch immobilized enzymeswhen combined with activated glycan library as kitscan hel ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel Probiotic for the Treatment of Sjogren's Syndrome

    SBC: Rise Therapeutics, LLC            Topic: NIDCR

    Project Summary Our goal is to develop a novelimmunologically enhanced Llactis probiotic based therapeutic for the treatment of Sj gren s SyndromeSjSSjS is a progressivechronic autoimmune disease characterized by inflammatory cell infiltration of the salivary and lacrimal glandsresulting in acinar epithelial cell atrophycell deathand loss of exocrine functionAt least half of SjS patients develop e ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. A Single-Cell Proteomic instrument for Predictive Product Quality Check in Autologous CAR-T Immunotherapies

    SBC: IsoPlexis            Topic: NCI

    While CAR T therapies have advanced in the clinicthere are still two specific issues using these breakthrough therapies for blood cancersDurable responses in patients are only atand Cytokine Release Syndrome occurs inof treated patientsThese limitationsfor a drug that costs as much as $may cost an additional $for treating adverse events leading to caution for many clinical centers to administer th ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) for relapse preventionin patients with Opioid Use (OUD)

    SBC: EVON MEDICS, LLC            Topic: NIDA

    The Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Cortex TrainingCBOTis an alternative strategy for relapse prevention in patients with Opioid UseOUDand other substance use disordersSUDOpioid and other forms of drug addiction can be defined as a failure to control drug seeking behaviorand reflect an exaggerated drive to consume drugsand or an inability to engage in ou ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Multi-Omic Single-Cell System for Improved Combination Cancer Immunotherapy Monitoring and Implementation

    SBC: IsoPlexis            Topic: 102

    IsoPlexis proposes to deliver a novel multi omic method for targeted profiling of both the TCR sequence and proteome from an array ofsingle cellsSpecificallywe will deliver a single cellTCR sequencing and protein capture assay for identifying responsive antigen specific TCRsand concurrently evaluate these T cells for functional response to that antigenThe challenge remains to link the activation o ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. ASSESSMENT OF MEDHERENT MEDICATION MANAGEMENT DEVICE AND ADHERENCE PLATFORM

    SBC: SEQUON, INC            Topic: 104

    Project Summary Abstract Individuals suffering from Serious and Persistent Mental IllnessesSPMIare at risk for adverse psychiatricsomatic healthand social outcomes with higher rates of heart diseasehigh blood pressureobesityand diabetesEssential to controlling chronic psychiatric and health disorders is improved care coordination and adherence to prescriptions that address the symptoms and causes ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Developing, Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARYThis application for a Phase II SBIR award extends the successful completion of Phase I and represents acollaboration between ClinitechLLC and McLean Hospital Harvard Medical School to continue thedevelopment of a wearable biosensor for detecting alcohol in the interstitial fluid of humansExcessive use ofalcohol accounts for much of the public health burden related to alcohol use di ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Using ACT01- DHA combination to Improve Conditions of FXS

    SBC: DRI Biosciences Corporation            Topic: NINDS

    Abstract and Project SummaryFragile X SyndromeFXSis a leading inherit cause of intellectual disabilityThe goal of this project is to develop effective medications to improve conditions of FXSThe proposed research is based on the hypothesis that a combined administration of ACTand DHA to the FmrKO micea mouse model of FXSwill rescue brain developmentThe hypothesis is based on experimental observati ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. OPTIMIZATION AND ASSESSMENT OF A BIOLOGIC TO IMPROVE FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY

    SBC: Alcamena Stem cell Therapeutics, LLC            Topic: NINDS

    ABSTRACTPeripheral nerve injuryPNIis a common and challenging clinical problem affecting overof U Strauma patientsAmong combat traumathe rate of PNI increases toThese patients require extensive resources for initial treatment and therapyyet they are still left with functional disabilityCurrent treatments for motorsensoryand mixed PNI include nerve autografts and axonal guidance tubesHoweverthese m ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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