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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Portable, affordable, quantitative microchip electrophoresis for hemoglobin A1C testing

    SBC: HEMEX HEALTH INC            Topic: 200

    PROJECT SUMMARY Diabetes is one of the most important health issues in the world. The number of people living with diabetes has quadrupled since 1980, with the greatest increase in prevalence in low and middle-income countries. Not only is diabetes a major cause of morbidity and mortality, but it can also devastate the finances of families and strain countries’ financial resources. World Health ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Renal Therapeutic Angiogenesis Using the Novel Biologic ELP-VEGF

    SBC: LEFLORE TECHNOLOGIES LLC            Topic: 400

    Abstract.Chronic kidney disease (CKD) is a progressive disorder affecting almost 14% of the general population, and this disease has shown a relentless growth over the past 2 decades. Patients with CKD have higher rates of hospitalization, greater mortality, shorter life expectancy, and their healthcare costs are up to 5 times more expensive than non-CKD patients. Thus, treatments to slow, halt, o ...

    STTR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Advancing mGlu1 positive allosteric modulators as therapeutics to facilitate abstinence in cocaine use disorder

    SBC: ELEUTHERIA PHARMACEUTICALS LLC            Topic: NIDA

    Project Summary A major challenge in treating cocaine use disorder is that vulnerability to cue-induced craving and relapse persist even after long periods of abstinence. There is presently no FDA-approved medication to lessen cocaine craving. The goal of Eleutheria Pharmaceuticals LLC is to develop metabotropic glutamate receptor 1 (mGlu1) positive allosteric modulators (PAMs) as therapeutic agen ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Targeting distinct DNA methylation signatures in pediatric glioma using HITMA

    SBC: NZUMBE INC            Topic: NCICA22

    Pediatric high-grade gliomas (pHGG) have proven to be extremely difficult to treat with a dismal survival rate. Fresh, innovative therapeutic approaches are desperately needed to combat this devastating disease. Hypomethylated Induced Target Mediated Apoptosis (HITMA), is a therapeutic strategy that targets and induces apoptosis only in cells that show an aberrant DNA methylation phenotype at repe ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. DEVELOPING A NOVEL NON-VIRAL NANOPIECES GENE DELIVERY SYSTEM FOR AD GENE THERAPY

    SBC: Nanode Therapeutics, Inc.            Topic: 4

    To develop a new, safe, and efficacious non-viral gene delivery system crossing the blood-brain barrier (BBB) for gene therapy of Alzheimer’s Disease (AD).

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Click City: Marijuana- An Interactive, Scalable, High-Fidelity, Digital Prevention Program for Youth

    SBC: OREGON RESEARCH BEHAVIORAL INTERVENTION STRATEGIES, INC.            Topic: NIDA

    ABSTRACT By the end of high school, close to half of 12th graders report marijuana use. While youth often perceive marijuana use as low risk, particularly as more states legalize marijuana for recreational and medical use, there are serious consequences of use by adolescents, including neurological impairment, mental health issues, and future dependence. Many current school-based drug prevention p ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Sourcerer IC: A Web-Based Integrative Multi-Modal Workflow for Epilepsy Surgical Planning

    SBC: Brain Electrophysiology Laboratory Company, LLC            Topic: 106

    Abstract The overarching goal of this project is to create software that improves the use of intracranial EEG to qualify patients with medication-resistant epilepsy for neurosurgery. One million people in the US suffer from continual seizures that are not controlled by medication. The current estimate is that half of these could be treated effectively by surgical resection of the epileptic cortica ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. DanFreez: Zebrafish Genetically-Optimized for Cryogenic Storage of Embryos

    SBC: NEMAMETRIX, INC            Topic: 100

    Summary: Unlike C. elegans and mice, methods for cold storage of zebrafish lines are lacking in the marketplace. We propose the use of environmental and gene c factors to enable cold storage of viable embryos at frozen or near freezing condi ons. In Aim 1 we will explore the use of transient protein expression to produce proteins associated with anhydrobio c status. In Aim 2 we explore the induc ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Caring4Caregivers: A theory-driven mobile solution to promote self-care and well-being among caregivers of individuals with Alzheimer’s andrelated dementias

    SBC: Pro-Change Behavior Systems, Inc.            Topic: R

    7. Project Summary/Abstract Over 11 million Americans are currently providing unpaid care to a family member or friend with Alzheimer's disease or a related dementia (ADRD). While caregiving can be a positive experience that brings meaning and an increased sense of purpose, it can also take a toll. Nearly 60% of ADRD caregivers rate their emotional distress as high or very high, and over 30% suffe ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. An adaptive compute solution for characterizing macromolecular complexes by mass spectrometry with electron-based fragmentation

    SBC: E-Msion, Inc.            Topic: 400

    Despite two decades of advances in the speed, resolution and mass accuracy of modern mass spectrometers, the characterization and quantification of biological macromolecules remains a daunting challenge. The remaining weakness with current instrumentation lies in the methods used to fragment macromolecules, which e-MSion is addressing with an efficient electron-fragmentation technology called ExD. ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
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