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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An Improved Robotic Electrophysiology Platform for Arrhythmia Ablation

    SBC: UNANDUP, LLC            Topic: NHLBI

    Arrhythmias result from disorganized electrical signals within the heart leading to irregular contractions and are a leading cause of death in the US. Ventricular tachycardia and fibrillation are the most serious arrhythmias resulting in 300k annual US deaths, followed by 130k US deaths due to atrial fibrillation (AF). With a prevalence of 6M in the US, AF is the most common arrhythmia, resulting ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  2. Innovation of Skin Banking and Transplantation Based on a First-in-Class Biocompatible Cryopreservation Technology

    SBC: CRYOCRATE LLC            Topic: NIAID

    SUMMARY Previous support from NIH SBIR and Coulter Foundation awards allowed the CryoCrate team to develop a first- in-class biocompatible cryopreservation medium product, trademarked as OdinSol®, that will provide efficient options for biobanking practices associated with storage of skin grafts from donors or xenotransplants. The OdinSol® technology removes the need for any toxic cell permeatin ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  3. Promoting adult hippocampal neurogenesis using antisense oligonucleotides as an Alzheimer's disease therapy

    SBC: BOLDEN THERAPEUTICS, INC.            Topic: NIA

    PROJECT SUMMARY There is an enormous need for therapeutics to prevent and treat Alzheimer's disease (AD). Adult Hippocampal Neurogenesis (AHN) is critical for normal learning and memory, but it declines in patients with AD. Work in animal models has underscored the role of AHN in improving cognition in the face of AD pathology. Thus, restoring AHN has emerged as an attractive target for an AD ther ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  4. Entrepreneurial development award for a novel Alzheimer's disease therapeutic

    SBC: BOLDEN THERAPEUTICS, INC.            Topic: Y

    The aging population in the US and globally has led to an urgent need for therapeutics to prevent and treat Alzheimer's disease (AD). Adult Hippocampal Neurogenesis (AHN) is critical for normal learning and memory and declines in patients with AD. Work in animal models has underscored the role of AHN in improving cognition in the face of AD pathology. Thus, restoring AHN has emerged as an attracti ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Novel Immunomodulatory Pyridone for the Treatment of Heart Failure with Preserved Ejection Fraction

    SBC: I-Cordis, LLC            Topic: NHLBI

    PROJECT SUMMARY/ABSTRACT Heart Failure with preserved Ejection Fraction (HFpEF) is one of the major drivers of healthcare costs in the western world and arguably the largest unmet need in cardiology. Currently, there are no FDA approved drugs to treat the vast majority of patients with HFpEF. Recently, the Phase II PIROUETTE trial showed that the immunomodulatory drug pirfenidone, marketed for the ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  6. Joyuus: A Web-based Tool for Postpartum Care Self-care to Address the Complex Needs of Underserved Women

    SBC: JOYUUS, LLC            Topic: 100

    PROJECT SUMMARY/ABSTRACT In the United States, the postpartum period is a critical time for both maternal and child health; the US maternal mortality rate is the highest among other developed, high-income countries. More than half of all maternal deaths occur postpartum, from one day to one year after birth.1-9 There are vast racial and ethnic disparities in maternal mortality and severe morbidity ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  7. Behavioral feedback and rewards for improving functional brain mapping in presurgical pediatric patients

    SBC: TURING MEDICAL TECHNOLOGIES INC            Topic: 106

    Project Abstract/Summary The objective of this psychological technology SBIR/STTR Fast-Track proposal is to provide an innovative gamified biofeedback solution (software-only) to improve the effectiveness of functional Magnetic Resonance Imaging (fMRI) for pediatric pre-neurosurgical planning. Maximal safe resection of an epileptic focus to optimize outcome is carefully balanced against impact on ...

    SBIR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Sotair for Improving Performance and Minimizing Complications of Manual Ventilation

    SBC: SAFEBVM CORP.            Topic: NHLBI

    Abstract Bag valve mask (BVM) resuscitators are the gold standard of emergency airway management and artificial respiration for patients who are not breathing adequately. However, a well-documented problem with BVMs is that they are often misused, regardless of the qualifications and experience of the provider, which can lead to dangerous complications such as gastric insufflation. Gastric insuffl ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  9. Rapid dissection of the biosynthesis of antiMRSA antibiotics produced in co-culture by extremophilic fungi through the development of Fungal Artificial Chromosomes

    SBC: INTACT GENOMICS INC            Topic: NIAID

    PROJECT SUMMARY. The economic and social burden of the treatment of infectious and chronic diseases is enormous, rt$300B annually. The ongoing COVID-19 pandemic alone will cost the U.S. economy roughly $8 trillion over the next decade without an effective drug to date. The emergence of drug resistant microbes, the diminishing supply of novel classes of antibiotics, and the dramatic reduction in Ra ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
  10. High performance and widely accessible secretomics assay platform

    SBC: Auragent Bioscience LLC            Topic: 400

    AbstractSecretory proteins are fundamental to local and systemic cellular signaling in biological systems. The regulation and dysregulation of the networks involving these proteins plays a critical role in health, aging, and development of disease. As such, study of these proteins and their networks is critical to our understanding of biology. Not surprisingly, this particular set of proteins cons ...

    SBIR Phase II 2022 Department of Health and Human ServicesNational Institutes of Health
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