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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Point-of-care immunoassay for early diagnosis of pertussis

    SBC: DxDiscovery Incorporated            Topic: NIAID

    DESCRIPTION provided by applicant Pertussis is a serious and potentially life threatening respiratory disease caused by the bacterium Bordetella pertussis Worldwide million people become ill with pertussis each year and of these patients die Despite high vaccine coverage in the United States there were still over pertussis cases reported in the U S in Rapid diagn ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  2. Expanding small molecule functional metagenomics through shuttle BAC expression i

    SBC: Intact Genomics Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Hospital acquired microbial infections are the fourth largest killer in America taking lives and adding $ B to hospital costs The emergence of drug resistant microbes has further amplified public health concern Fungi are prolific producers of anti microbial secondary metabolites SM and since the turn of the century have provided of bioactive m ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  3. MIST System for Simultaneous Parallel Intracellular Delivery & Transfection

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: 400

    DESCRIPTION provided by applicant Alternative nanomaterial and gene transfer solutions are needed to access the potential held in intracellular imaging biopharmaceuticals gene therapy and stem cell research Delivery of small and macromolecules including nucleic acids drug molecules imaging agents peptides antibodies and enzymes into cells is criti ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Galectin 1: A novel small protein therapy for Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: NIAMS

    DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Identification of Borrelia burgdorferi diagnostic biomarkers in humans and nonhum

    SBC: DxDiscovery Incorporated            Topic: NIAID

    DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

    STTR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  6. Anti-virulence FimH inhibitors for the treatment and prevention of UTIs

    SBC: FIMBRION THERAPEUTICS, INC.            Topic: NIAID

    DESCRIPTION provided by applicant Over million women suffer from urinary tract infections UTI annually in the U S and approximately of these patients suffer from multiple recurrences UTI is unique in its high prevalence of chronic recurrent infections which has caused a tremendous need for long term conventional prophylactic therapy This is leading to increased antimicrobial res ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  7. Experimental Design Software for Translational Gastrointestinal Microbiome Studie

    SBC: WILLIAM D SHANNON CONSULTING LLC            Topic: 300

    DESCRIPTION provided by applicant Design of experiments and test of hypotheses need to be available to research teams to develop and validate taxonomic metagenomic biomarkers in gastrointestinal tract GIT diseases The translational research team needs to design an experiment to test a hypothesis e g microbiota in Crohnandapos s disease is different than in normal controls calculat ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Rapid STEMI Fibrinolysis for Underserved Populations

    SBC: Pulse Therapeutics, Inc.            Topic: NIMHD

    DESCRIPTION provided by applicant Coronary heart disease CHD accounts for every of deaths in the United States US with acute incidences estimated at M annually Of these up to are classified as ST elevation myocardial infarction STEMI in which a clot blocks a coronary artery leading to a change in the ECG ST wave Because the heart muscle rapidly dies time to re ...

    SBIR Phase I 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Direct RT-PCR detection of RNA pathogens in crude samples

    SBC: DNA POLYMERASE TECHNOLOGY, INC.            Topic: 200

    DESCRIPTION provided by applicant The objective of this application is to introduce a novel simplified low cost technology to address the broad need of detecting RNA pathogens directly in crude samples such as blood Traditional RT PCR requires purifying the RNA which increases the cost time and risk of cross contamination We intend to reduce or eliminate the purification step by producin ...

    SBIR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Computational tools to analyze SNP data from patients with mental illness

    SBC: PARTEK, INC.            Topic: 101

    DESCRIPTION provided by applicant The broad long term objective of the proposed research is to develop and market a commercial software product that can be used to facilitate the analysis of genetic changes in order to elucidate chromosomal abnormalities that underlie diseases such as autism spectrum disorder bipolar disorder and schizophrenia Recent technological advances allow samples of ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health

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