Award Data

DESCRIPTION provided by applicant Placental measures of roundness cord insertion centrality volume shape and thickness are biomarkers of maternal fetal growth Deviations from expected placental morphology even as early as weeks are related to placental dysfunction and pregnancy complications such as preeclampsia pregnancy hypertension gestational diabetes mellitus and fetal chromo ...

DESCRIPTION provided by applicant Autism is the fastest growing developmental disorder in the United States with that affects about in children Thus not surprisingly the cost and burden on families patients and caregivers is enormous Associated with autism spectral disorder are other pervasive developmental disorders that include Rett syndrome Phelan McDermid syndrome and Fragile X ...

DESCRIPTION provided by applicant The overall goal of this SBIR Phase II proposal is to develop and validate a fully commercialized instrumented gait analysis system and associated training and reporting tools Gait dysfunction can dramatically affect a personandapos s ability to perfor activities of daily living and assessment of gait is a critical component of physical therapy practice Cur ...

DESCRIPTION Infections are a leading cause of mortality in adult and pediatric ICUs Earlier diagnosis and treatment of infection could significantly reduce patient morbidity and mortality Unfortunately current methods of detection cannot routinely detect infection early in the disease course Isomark has developed a breath based early detection technology biomarkers and instruments for detect ...

Summary abstract The proteins encoded by the human genome may participate in as many as pairwise protein interactions and nearly every major process in a cell is carried out by assemblies of or more interlocking protein molecules Bruce Alberts Cell However there are no commercially available expression systems for regulated expression of multi subunit protein complexes The ...

DESCRIPTION provided by applicant Most drugs interact with protein molecules to elicit a cellular response Traditional drug discovery is a laborious and expensive experimental process so computational approaches to assess protein function and to accelerate the discovery process are in high demand Virtual drug screening and structure based drug design represent computational approaches that c ...

DESCRIPTION provided by applicant Osteoarthritis OA is a significant contributor to human morbidity and mortality with an economic burden exceeding $ billion annually in the United States Lubricin is a natural lubricant of the articular cartilage of the knee and the intraarticular administration of lubricin prevents OA progression following knee injury However the manufacture of lubrici ...

DESCRIPTION provided by applicant Respiratory infections with influenza viruses cause severe morbidity and mortality in humans and animals worldwide Importantly in humans the majority of morbidity and mortality following flu infection is seen in older individuals andgt year old Yet clear understanding of how aging impacts on innate immune responses and how to improve vaccine design ...

DESCRIPTION provided by applicant Prostate cancer PCA is the most common non skin cancer and the second leading cause of cancer death in American men with over new cases diagnosed and over PCA deaths annually in the United States Ultrasound guided biopsy is the standard of care for confirming cancer typically following elevated PSA levels however it has been estimated that ...

DESCRIPTION provided by applicant The goal of this Phase I is to develop a prototype for a novel antiviral therapy directed towards Epstein Barr virus based on a novel post transcriptional regulatory mechanism called structurally interacting RNA or sxRNA We are pioneering a revolutionary antiviral approach that uses a viral encoded microRNA miRNA to create specificity even in infections in t ...