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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Axonal Transport HTS Platform for Neurodegeneration Drug Discovery

    SBC: Bellbrook Labs, LLC            Topic: 106

    DESCRIPTION provided by applicant Neurodegenerative diseases that affect motor neurons such as PD ALS and HD represent an enormous unmet medical need that is growing with the aging population Existing treatments have little or no effect on the course of disease and patients have to cope with the loss of brain and body function for the rest of their lives Defects in the transport of organell ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Automated Assessment of Leptomeningeal Collaterals on CT Angiograms

    SBC: Kitware, Inc.            Topic: 108

    DESCRIPTION provided by applicant The primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiography CTA as a quantitative assessment of acute stroke Leptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal occlusion The presence and effectiveness of leptomeningeal collaterals i e andquot c ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. IMMEDIATE FIT USING INNOVATIVE TECHNOLOGY TRANSTIBIAL PROSTHESIS

    SBC: IFIT PROSTHETICS, LLC            Topic: NIA

    DESCRIPTION provided by applicant The goal of iFIT Prosthetics LLC r and its founder was to create and commercialize a modular immediate fit fully adjustable transtibial prosthesis system suitable for mass production using high strength polymer materials that are injection molded at a fraction of the cost of conventionally made prostheses This goal was achieved and now the aims of this P ...

    STTR Phase II 2015 Department of Health and Human Services
  4. A Universal Flu Vaccine Based on Conformationally Locked Soluble Headless HA

    SBC: AVATAR MEDICAL, LLC            Topic: NIAID

    DESCRIPTION provided by applicant An influenza pandemic remains an acute threat to world health and stockpiling a universally protective influenza vaccine provides a strong defense against this potential catastrophe The hemagglutinin HA protein is the primary target of humoral Ab responses to Influenza Vaccines based on full length HA give rise predominantly to strain specific Ab response ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. Balancing Immunogenicity of a Tetravalent Live Attenuated Dengue Vaccine

    SBC: Codagenix Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Dengue virus DENV infections are the leading mosquito borne human viral diseases in the world with billion people at risk of infection The diseases caused by DENV range from a self limiting Dengue fever DF to the life threatening hemorrhagic DHF and capillary leak syndrome Dengue shock syndrome DSS DENV accounts for possibly million infectio ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  6. Optimization of Supercritical Carbon Dioxide Based Virus Inactivation, Characterized by Protein Damage and Maintenance of Epitope Integrity in Vaccine Sterilization

    SBC: NOVASTERILIS            Topic: NIAID

    DESCRIPTION provided by applicant The process combining supercritical CO and co sterilants produces strong synergistic microbicidal effects in relatively mild conditions The mechanism of microbe inactivation is not well characterized but the disruption of lipid membranes and mild oxidative damage appear to be involved The process which is also highly efficient against viruses is considere ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Sporocidal Mechanism and Inline Monitoring of Peracetic Acid in Supercritical CO2

    SBC: NOVASTERILIS            Topic: NIAID

    DESCRIPTION provided by applicant It is critical to sterilize biomedical devices xenograft and allograft materials due to the rapid rise of antibiotic resistance in hospital acquired infections HAI For one major HAI pathogen Clostridium difficile the use of antibiotics promotes greater infection rates and worse outcome as the native intestinal flora is eliminated by the strong antibioti ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Development of Molecular Diagnostic Test For Early Onset of Lyme Disease

    SBC: BIOSCIENCE DEVELOPMENT INC            Topic: NIAID

    DESCRIPTION provided by applicant There is no validated assay to reliably detect the early onset of the Lyme disease infection at the time when antibiotic therapy has the best chance of a cure without sequelae Diagnosis is often difficult because most symptoms are often nebulous with the telltale andquot bulls eyeandquot rash only appearing and clearly recognizable in approximately half of c ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. NOVEL ULTRASENSITIVE CANCER BIOMARKER ASSAY PLATFORM UTILIZING PALLADIUM CATALYZED HIGH-GAIN CHEMICAL AMPLIFICATION

    SBC: CATASSAYS            Topic: NCI

    DESCRIPTION provided by applicant We propose to use CatAssaysandapos novel Palladium Catalyzed Chemical Amplification PdCCA technology platform to develop ultra sensitive sandwich ELISA format bioassays to detect very low concentrations of a number of critical cancer and immunoregulatory biomarkers CatAssaysandapos PdCCA technology the first example of the application of heterogeneous me ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a Minimally Invasive Surgical Device for the Treatment of Esophageal Cancer

    SBC: CELL PRESERVATION SERVICES INC            Topic: NCI

    DESCRIPTION provided by applicant The treatment of Esophageal Cancer has experienced a palpable increase in the last few years While numerous options are currently under investigation many if not all remain suboptimal This is critical as it is estimated that in there were new cases and over deaths from esophageal cancer worldwide In the US alone there were new ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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