Award Data

Combat soldiers are exposed to vast numbers of dangerous chemicals with potentially adverse health outcomes.This SBIR proposal aims to develop a new class of saliva based diagnostic assays that will measure the bodys response to toxic chemical exposure via a panel of clinically used biomarkers that are indicative of organ injury.The tests will leverage the proven functionality of lateral flow diag ...

The applicant developed the modular Sterile Saline Solution System (S4), for remote site production of Sterile Physiologic Saline. It used Available Surface Water of poorer quality for particulates, chemical contaminants, microbes and biologicals than the EPA Grade Drinking Water Standards (EGDWS) specifies and dry reagent formulation. This system is the subject of an FDA assigned Investigational ...

Currently, deployed medics are required to transport, maintain and be resupplied with liquid-based medications and materials that are heavy, expensive to transport, perishable and may require refrigeration.Many medications and materials are or will be available in dehydrated formularies that require sterile water for injection (SWFI) to rehydrate for immediate use, such as freeze-dried platelets.I ...

A recent study of battlefield casualties found that over 90% of potentially survivable mortality cases were associated with hemorrhage. It is critical to maintain fluids and prevent hemorrhagic shock as soon as possible after the injury. However, medics must plan for and carry these bulky solutions to the point of injury, and additional casualties could exhaust limited available supplies. Mainstre ...

To address the DHP need for a deployable, controlled hypothermia device, Physical Optics Corporation (POC) will further improvise on our Fast and Smart Cooling Equipment for Enhanced Neuroprotection (FASCOOL) based on research results of a previously funded DARPA SBIR. The FASCOOL program will leverage findings from that program and augment the device by adding a new feedback/control mechanism to ...

Traumatic brain injury (TBI) impacts over two million Americans annually, and is the signature injury of the Iraq and Afghanistan conflicts. Therapeutic hypothermia is a promising neuroprotective technique for treating TBI, but reduced body temperature is a threat to soldiers in military operations with multiple injuries. Mainstream has proposed a novel vapor compression cooling system that overco ...

Selective Aortic Arch Perfusion (SAAP) was invented by Manning specifically to treat both traumatic and non-traumatic/medical cardiac arrest. SAAP uses a descending aortic arch balloon occlusion catheter to selectively perfuse the heart and brain to restore intrinsic cardiac function and limit neurological injury. In hemorrhage-induced traumatic cardiac arrest (HiTCA), aortic occlusion controls su ...

Hyperkalemia will clearly continue to be a concern in the treatment of combat casualties. The risk of death from hyperkalemia-induced cardiac arrhythmias is significant in the absence of renal replacement therapy (RRT).Rapid evacuation out of Iraq and Afghanistan ensured that most hyperkalemia occurred further up the evacuation chain, thereby limiting the need for non-RRT hyperkalemia treatment op ...

Hyperkalemia continues to be a concern when treating combat casualties. Current hemodialysis systems use a dialysate in a membrane contactor to replicate the function of the kidney by removing the toxins, excess fluid and the minerals. The dialysis machines used in hemodialysis centers are bulky. There are home dialysis machines that are smaller but not person portable and weighing about 70lbs.Sim ...

Defense Health Program (DHP) seeks to develop a new and innovative medical device tailored to prevent or treat accumulation of blood in the pleural space after chest trauma or surgery (i.e. retained hemothorax). Critical Innovations, NeoMatRx, Milestone Strategies, and The FDA Group, in addition to consultant Captain David Plurad, MD, FACS (USN, Ret.), have formed a team of medical device experts ...