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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Not Available

    SBC: LEADSCOPE, INC.            Topic: NIEHS

    The last two decades have produced dramatic technological advances in molecular biology and computer science. The NTP is evaluating how best to incorporate these advances into its research and testing strategies in order to broaden scientific knowledge of exposure-related disease mechanisms. To support these efforts, the goal of this contract is to develop a PC and/or Mac-based integrated predi ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. PHASE I- MOTION SIMULATION EFFECTIVENESS ON COLICKY

    SBC: Sweet Dreems Inc.            Topic: N/A

    N/A

    SBIR Phase I 1983 Department of Health and Human Services
  3. Optimization of Protein Therapeutic Formulations

    SBC: SOLUBLE THERAPEUTICS, INC            Topic: NIGMS

    DESCRIPTION (provided by applicant): This proposal involves the development and validation of a novel approach to improve and accelerate the discovery of biopharmaceuticals (i.e. vaccines, monoclonal antibodies and other therapeutic proteins). Biopharmaceuticals are used to treat a variety of infectious and chronic diseases. The proposed research is intended to establish a new paradigm for rapidly ...

    STTR Phase I 2010 Department of Health and Human Services
  4. Fluorescence Intensity-Based Scoring of Macromolecule Crystallization Plates

    SBC: IXPRESSGENES, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure-function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals, and is a major area of NIH research. Crystallization however is also the rate limiting step, despite techn ...

    STTR Phase I 2010 Department of Health and Human Services
  5. In Vivo Assessment of Embryonic Stem Cell Teratoma Prevention

    SBC: BIOINVISION INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The capacity to evaluate the teratoma forming potential of differentiated embryonic stem cell populations represents an urgent need before widespread therapeutic application of these cells is possible. Researchers at Case Western Reserve University and BioInVision, Inc. will join together to create platform technologies for validating existing embryonic stem ce ...

    STTR Phase I 2010 Department of Health and Human Services
  6. Small Molecule targeting of NADPH oxidase in neutrophils

    SBC: P2D, INC            Topic: NHLBI

    DESCRIPTION (provided by applicant): Acute lung injury (ALI) and Acute Respiratory Distress Syndrome (ARDS) are characterized by a rapid and severe respiratory failure, arising after clinical events including major surgery, trauma, multiple transfusions and sepsis. ALI/ARDS have an associated mortality of 40-80% and current pharmacological modalities have been unsuccessful in decreasing mortality. ...

    STTR Phase I 2010 Department of Health and Human Services
  7. Development of a BBB Model to Study Transendothelial Cell Migration

    SBC: FLOCEL INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Increasing evidence indicates that systemic inflammation and the blood-brain barrier (BBB), which becomes the target of overreacting or misguided immune cells that determine BBB failure and immune extravasations into the brain parenchyma, are involved in the pathogenesis of neurological diseases such as meningitis, inflammation, Alzheimer's disease, and multipl ...

    STTR Phase I 2010 Department of Health and Human Services
  8. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: NHLBI

    DESCRIPTION provided by applicant The overall goal of this project is to demonstrate the ability of our acute myocardial infarct selective paramagnetic contrast agent Gadolinium ABE DTTA to differentiate between acute and chronic infarcts in a reliable manner using contrast enhanced magnetic resonance imaging ceMRI In our Phase I data we have shown that Gd ABE DTTA exclusively highlight ...

    STTR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  9. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms

    SBC: DISCOVERYBIOMED, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Title: Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms Project Summary Statement The Problems: Complementary and alternative medicine (CAM) is an understudied scientific discipline. It is unappreciated that many biologically active and therapeutically beneficial compounds are derived from botanicals. Moreover, the scientific me ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. High-Throughput Ex Vivo Tumor Cell Motility Assay

    SBC: Nanofiber Solutions, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Gliomas are the most aggressive and least successfully treated brain tumors because of their distinctive ability to infiltrate surrounding brain tissue. Even if the bulk of the tumor is removed, migratory cells left behind are not detected by the immune system and resist current cytotoxic therapies. Tumor recurrence then typically involves a rapid and deadly ou ...

    SBIR Phase I 2010 Department of Health and Human Services

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