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Project Summary Abstract The goal of this project is to complete the pre clinical and translational studies necessary to prepare a novel oncolytic viralOVtherapyWO Sfor clinical evaluation in non small cell lung cancerNSCLCNSCLC is the predominate form of lung cancerwhich is the leading cause of cancer death in the United StatesRecentlyimmunotherapies have emerged as a potential new treatment appr ...

Abstract An estimatedmillion Americans ageand older are living with Alzheimerandapos s diseaseADand as the population agesthis number is expected to rise tomillion byAgitation is one of the most common and distressing neuropsychiatric symptoms of Alzheimerandapos s disease and related dementiasADRDfor patients in the ambulatory and long term careLTCsettingsAgitation contributes to increased health ...

Abstract Despite overall declines in the rate of tobacco use in the United States over the past years nearly million Americans still smoke posing extremely high risk for long term health problems and death There has been extensive research evaluating a wide range of smoking cessation approaches over the past years Recent reviews note that there has been significant progress in the application of b ...

SUMMARY Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require multiplestaged surgical interventionsA significant source of the heightened morbidity and mortality associated with these operations is the development of cardia ...

Project Summary AbstractThe recent rapid expansion of genomic data greatly contributes to the understanding of disease development and progressionTo translate these genetic discoveries into clinical applicationswe need to develop therapeutic platforms that can specifically modulate the expression of disease related genes in vivoSmall RNAssuch as microRNAs and siRNAs function in messenger RNA silen ...

PROJECT SUMMARY Osteogenesis imperfectaOIalso known asbrittle bone diseaseis a genetic disease in which patients have defects in the formationstructureor strength of their bonescausing them to break easilyOI patients exhibit impaired tissue development and bone regeneration due to inherited mutations in one of the collagen genesleading to skeletal defectsbone fragilitydentinogenesis imperfectahear ...

Triple negativePRERHERbreast cancerTNBCwhich disproportionately afflicts premenopausal and minority womenhas a very poor prognosisCurrent TNBC treatment consists of combination chemotherapy which is toxic to the patientincreases morbidity and decreases quality of lifeConsidering these limitationsand high relapse rateTNBC poses a major clinical challengeand developing new agents that are effective ...

AbstractThe overall goal of this study is to develop and demonstrate a novelpredictive in vitro organotypicD culture models of the blood brain barrierBBBderived from rodents for chemical toxicity screeningIn contrast with current Transwell based static and microfluidic assaysour commercially available SynBBB model enables real time visualization and quantitation of transport permeation under physi ...

Ventricular assist devicesVAD sclearly have a role in cardiac medicinehow to precisely define that role is still subject to research and debateconsidering the possibilities of destination therapybridge to transplantbridge to recoverybridge to definitive therapy and possibly other variants one might specifyCertain VAD features are emerging as requiredadequate output to truly make a difference to th ...

PROJECT SUMMARYThree of top five causes of death in humans globally are lung relatedchronic obstructive pulmonary diseaseCOPDlower respiratory infections and lung cancers collectively account for over eight million deaths annuallyCurrentlyin preclinical settingstatic cell cultures and animal models are the most widely used systems for mechanistic and translational studiesHowevercritical limitation ...