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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. development of immunodeficient rabbit models

    SBC: Celetrix LLC            Topic: NIAID

    DESCRIPTION provided by applicant Transplantation of human or animal pluripotent stem cells PSCs or their derivatives to model animals constitutes an important preclinical system to model and investigate cell survival development and differentiation in vivo and to assess the safety and efficacy of transplantation based cell therapies Immunodeficient mice are dominantly used in biomedical ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Development of DRα1-MOG-35-55 for treatment of DR2 negative MS subjects

    SBC: VIROGENOMICS BIODEVELOPMENT INC            Topic: NIAID

    DESCRIPTION provided by applicant Our laboratory discovered and is developing partial p MHC class II constructs pMHC as a possible immunotherapy for multiple sclerosis MS pMHC containing the extracellular domains of the MS risk factor HLA DR linked covalently to the encephalitogenic peptide of myelin oligodendrocyte glycoprotein pDR MOG can reverse CNS inflammation and ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Clinical real-time resting state fMRI

    SBC: NeurInsight, LLC            Topic: 108

    DESCRIPTION provided by applicant Surgical resection of brain neoplasms aims at maximizing long term survival by gross total resection of tumor tissue while preserving the patientandapos s functional status Task based functional MRI fMRI is increasingly used as an adjunct to intra operative electrocorticography for mapping eloquent cortex but suffers a significant failure rate due to funct ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Monitored Breathing Awareness Therapy for Insomnia Disorder in Older Adults

    SBC: ADVANCED MEDICAL ELECTRONICS CORP            Topic: NIA

    DESCRIPTION provided by applicant Insomnia of sufficient clinical severity to meet diagnostic criteria is present in approximately of older adults nearly million individuals n the US alone If left untreated it can lead to increased rates of depression cognitive impairment and cardiovascular disease Treatment relies on pharmacotherapy such as sedative hypnotic therapy which is ass ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Lab-on-a-patch for neonates to monitor real-time glucose and reduce needle pain

    SBC: ZANSORS LLC            Topic: NICHD

    DESCRIPTION provided by applicant This STTR grant is aimed to reduce pain from repeated needle pricks by improving the monitoring of glucose homeostasis GH in neonates by developing a real time glucose monitoring device The innovation utilizes a micro needle based lab on a patch platform invented by STTR partner George Washington University GWU GH is usually monitored by blood test via a ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Discovery of alpha4beta2 Nicotinic Receptor Antagonists as Alcohol Abuse Medications

    SBC: ASSUAGE PHARMACEUTICALS, INC.            Topic: NIAAA

    PROJECT SUMMARY Alcohol addiction and disorders associated to excessive alcohol use are a serious public health problem in the United States and in other parts of the world Current pharmacotherapies for the treatment of these disorders show limited efficacy Preclinical and clinical findings point to nicotinic acetylcholine receptors nAChRs as an alternative promising target for the developmen ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Stabilization of Influenza Vaccine by Silica-Coating

    SBC: STONESTABLE, INC.            Topic: NIAID

    The goal of this Phase I STTR grant proposal is to stabilize live attenuated influenza vaccine LAIV using a temporary silica coating that is removed in vivo In so doing we will establish a broader technology to eliminate the cold chain required for transport of heat and cold labile vaccines Many vaccines are unstable under ambient environmental conditions Currently vaccines are either stabil ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Simple, low cost assay for detection of HIV-1 antiretroviral resistance in resource-limited settings

    SBC: Discidium Biosciences, LLC            Topic: NIAID

    Antiretroviral therapy has become a reality in resource limited settings thanks to entities such as PEFAR and the Global Fund However contrary to the therapeutic choice flexibility in developed countries all patients go on reverse transcriptase inhibitor RTI based first line regimens with more expensive protease and integrase inhibitor based regimens being reserved as second line therapy for ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Product Development of Intensity Modulation for Bolus Electron Conformal Therapy

    SBC: Decimal, LLC            Topic: 102

    Project Summary Abstract Electron beam therapy EBT using MeV beams provides effective radiation treatment for superficial cancers depthandlt cm As many as of radiotherapy patients in USA annually are eligible for electron therapy for some portion of their treatment making it the second most used external beam modality As many as of these electron patients ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Cognitive Change Battery: An Assessment for Serial Administration

    SBC: COGMETRIC LLC            Topic: NIA

    ABSTRACT Detecting change in neuropsychological functioning over time is critical for proper diagnosis and management of many neurological psychiatric and psychological conditions It is well documented that most commonly used cognitive assessments produce significant retest effects such as practice and regression to the mean effects Retest effects can cause substantial changes in test score ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
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