Award Data

ABSTRACT Although arteriovenous fistulae AVFs are the preferred mode of dialysis vascular access over fail to mature in that they do not develop an adequate blood flow or diameter to support hemodialysis This results in a very significant clinical morbidity and economic cost At a pathogenetic level AVF maturation failure is due to a small vessels b bad non laminar hemodynamic pr ...

Project Summary Pancreatitis is a significant public health problem accounting for over $ Billion of health care costs annually Approximately one third of patients with acute pancreatitis will go on to have recurrent pancreatitis Of those about will progress to chronic pancreatitis a painful disease with an increased risk of both diabetes and pancreatic cancer More than of people w ...

DESCRIPTION provided by applicant Insulin resistance IR also known as metabolic syndrome is tied to obesity and is associated with numerous modern health problems including the growing problems of type diabetes and cardiovascular disease The growing health economic and social burdens of these conditions calls for the need to develop drug treatments for IR We know from multiple lines of ...

DESCRIPTION provided by applicant Chronic viral hepatitis is clinically silent until development of cirrhosis and hepatic decompensation Decompensated cirrhosis is a precursor to liver failure and is associated with increased risk of severe esophageal bleeding significant cardiovascular events and death The gold standard for diagnosing cirrhosis is liver biopsy though problems with the pro ...

DESCRIPTION provided by applicant Directed Chemotherapy Delivery for Leptomeningeal Metastases PI Lad Shivanand and McCabe Aaron Project Summary Leptomeningeal Metastases LM is a condition in which cells from a primary solid or hematological tumor metastasize invade the subarachnoid space and spread throughout the cerebrospinal fluid CSF resulting in seeding of the leptomeninges along ...

DESCRIPTION provided by applicant Of all the hundreds of types of synthetic middle ear implants that are used in surgery approximately of these are rejected by the body These include total ossicular replacement prostheses TORPs and partial ossicular replacement prostheses PORPs TORPs are used in general when during surgery it is noted that the malleus incus and stapes are all absen ...

PROJECT SUMMARY This proposal aims to develop a new small molecule drug to be advanced into human clinical trials for the treatment of cocaine addiction According to the National Institute on Drug Abuse illicit drug use cost the United States more than $ billion annually in expenses related to crime lost work productivity and health care Approximately million Americans aged or older ...

DESCRIPTION provided by applicant Congenital diaphragmatic hernia CDH affects in newborns CDH is a disorder in which part of the diaphragm fails to form allowing abdominal organs to migrate into the chest resulting in lung hypoplasia underdevelopment in affected infants Although great strides have been made in the management of this disease significant morbidity and mortality p ...

ABSTRACT This STTR Phase I resubmission describes a small deceptively simple portable device called Speed Bumps that rapidly quantifies the sensation of flutter on the feet toes or fingers in micrometer m units Flutter frequency is to Hz which is below the approximate lower vibration range of to Hz This high sensitivity device is designed to differentiate the small variati ...

DESCRIPTION provided by applicant For this Phase I STTR proposal the investigators plan to develop the radiofrequency RF coil technology required for high resolution fMRI at T In the absence of a body transmit coil all T head coils must also incorporate a transmitter in addition to the receiver Here we propose a transmit array with up to individual channels combined with a receive a ...