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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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Developing an efficient E-cigarette aerosol generation and exposure system for rodent models with aerosol characteristics equivalent to those inhaled by E-cigarette usersSBC: AUTOMATE SCIENTIFIC, INC. Topic: NIDA
Abstract E cigarettes (E-cigs) are increasingly popular worldwide, in particular, among youths. E-cigs may contribute to nicotine addiction and are unlikely to discourage conventional cigarette smoking. Mainstream and second-hand E-cig aerosols contain, in addition to nicotine, detectable levels of toxins including carcinogens and heavy metals such as formaldehyde, benzene, nitrosamines, cadmium a ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
Clinical validation and commercialization of a novel hydrogel-based vaginal packing system for pelvic brachytherapySBC: BrachyFoam, LLC Topic: 102
This proposal aims to complete preclinical validation and commercialize a novel vaginal packing product based upon a biocompatible polymer hydrogel strategy. The hydrogel will form in situ after being injected into a bag placed within the vaginal cavity during pelvic brachytherapy. The hydrogel packing can then be removed readily after the brachytherapy treatment. This Phase II proposal focuses on ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: RAFT PHARMACEUTICALS LLC Topic: NIAID
PROJECT SUMMARY Asthma, characterized by airways obstruction with symptoms of wheezing, shortness of breath, chest tightness and consequently cough, remains a significant health problem. While advances in bronchodilator, corticosteroid and Th2-targeting therapy allow for well-controlled asthma in a large population of patients, subjects with severe, corticosteroid resistant asthma require frequent ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
A Randomized, Blinded, Placebo-Controlled Clinical Trial to Evaluate Longeveron Mesenchymal Stem Cell (LMSC) Therapy for Treating The Metabolic SyndromeSBC: Longeveron LLC Topic: NIA
The metabolic syndrome (MetS) is a cluster of factors that increases the risks for cardiovascular disease, type 2 diabetes mellitus, and mortality, and currently affects andgt; 40% of US adults. MetS is associated with endothelial dysfunction, decreased circulating endothelial progenitor cells (EPCs), and a pro-inflammatory state. We have made the exciting discovery that therapy with allogeneic me ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: GPB Scientific, Inc. Topic: 101
ABSTRACT The goal of this Fast-Track STTR project is to develop a Deterministic Lateral Displacement (DLD) microfluidic device that can enrich white blood cells (WBCs) from a typical leukapheresis unit in 1 hr, for use in manufacturing cancer cellular immunotherapy. Chimeric antigen receptor T cell (CAR-T) therapy has been recommended for FDA approval to treat relapsed or refractory pediatric and ...STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
Targeting bacteria, the innate response of the middle ear to infection, and host-pathogen interactions, using topical and transtympanic applications for the treatment of otitis media.SBC: EARNANO LLC Topic: NICHD
Otitis media is a world wide disease primarily affecting the pediatric population under the age ofyearsIt is the most common reason for pediatric care visits and antibiotic therapyOver prescription and poorcompliance have led to a reduced susceptibility of bacteria to antibiotics andconsequentiallyto recurrent and chronic ear diseasesClearlythere is a compelling need to investigate alternative the ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: POINT DESIGNS, LLC Topic: NICHD
The Point DigitA Ratcheting Prosthetic Finger UsingAdvanced Rapid Manufacturing Technology Project SummaryAbstract The goal of the proposed project is to develop and commercialize a purely mechanicalratcheting prosthetic fingerthe Point Digitwhichhas an industry leading strength to weight ratiocan be operated unilaterallyone handedoffers anatomical rotation and flexion around the patient s metacar ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: Inheret, Inc Topic: NCI
Project Summary This project is to complete the developmentintegration with the electronic medical record and human testing of the InheRET Inherited Risk Evaluation ToolInheRET s aim is to quickly and easily identify individuals at increased risk for hereditary diseasesthereby facilitating their to access downstream risk appropriate carereducing morbidity and mortalityInheRET s unique features red ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: CreCare, LLC Topic: NICHD
Development of a Functional Assessment for Children and Youth who are Hospitalized Project Abstract The objective of this project is to develop a marketable clinician reportedjudgement based functional assessmentusing contemporary measurement technology that transforms the assessment of children hospitalized in the USItem response theoryIRTand computer adaptive testCATprinciples will be used to di ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
SBC: AEROSOL DEVICES INC Topic: NIAID
Aerosolized pathogenssuch as Influenza virusescan spread rapidly and silently throughout a populationcausing severe outbreaks that can be difficult to controlEarly detection of these airborne pathogens is key to controlling outbreaksespecially among vulnerable populations such as in hospitalstreatment centers or nursing homesYet available methods are neither rapidnor portableCurrent methods rely h ...STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health