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SBC: BERTEC CORP Topic: NIA
Falls are a significant source of early morbidity and mortality in the aging populationyet the neurologicalsensoryand motor changes that lead to increased fall risk often escape early identification and interventionVital signs are commonly used in clinical settings to assess the cardiovascular systemblood pressureheart rateimmune systembody temperatureand the respiratory systemrespiratory rateto e ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
Development of Spleen Tyrosine Kinase (SYK) negative allosteric modifiers for therapeutic intervention in Alzheimer's disease.SBC: ARCHER PHARMACEUTICALS, INC. Topic: NIA
Pathological hallmarks of Alzheimerandapos s diseaseADinclude extracellular deposits of Apeptidesintraneuronal aggregates of abnormally phosphorylated tau protein and neuroinflammationMost proposed AD disease modifying therapies have focused on strategies that reduce brain Aamyloid or tau pathological accumulationHoweversuch approaches have been unsuccessful in late stage AD clinical trials and ma ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: N8 MEDICAL INC Topic: NHLBI
ABSTRACT Infection is a serious and potentially fatal complication of surgery to deliver cardiovascular implantable electronic devicesCIEDsi epacemakers and implantable cardioverter defibrillatorsUntreated device related infection is associated with mortality rates as high asCurrentlyonly one antibiotic impregnated mesh has been FDA approved for placement in surgical incisions to reduce infections ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
TAPS-ESP: Tobacco, Alcohol, Prescription Drug, and Illicit Substance Use- Electronic Spanish Platform: Technologies to Increase Screening in Primary Care to Reduce Behavioral Health DisparitiesSBC: COG ANALYTICS, LLC Topic: 102
ABSTRACTTAPS ESP Language accessibility and cultural awareness are essential elements of quality healthcareLimited English ProficiencyLEPindividuals are less likely to self identify a need for behavioral health serviceswhich results in longer duration of untreated disordersAccurate identificationdiagnosisand treatment are entirely dependent on a linguistically accurate screening and assessmentespe ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: HEMEX HEALTH INC Topic: NIDDK
PROJECT SUMMARY Diabetes is one of the most important health issues in the worldIt is a disease that disproportionately affects low and middle income countriesNot only is diabetes a major cause of morbidity and mortalityit can devastate the finances of families and strain countriesfinancial resourcesKey components for addressing this healthcare crises include early diagnosis as well as ongoing mon ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
3D Holographic Guidance, Navigation, and Control (3D GN&C) for Endovascular Aortic Repair (EVAR)SBC: CENTERLINE BIOMEDICAL INC Topic: NHLBI
Project Summary This project will develop newD visualization to improve stent graft deployment during minimally invasive endovascular aortic repairEVARby overcoming limitations ofD x ray fluoroscopyfluoroD holographic guidancenavigation and controlD GNandamp Cwill be provided to decrease fluoro radiation dose burden to patients and OR staff during treatment of aortic aneurysmsparticularly when dep ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: RITHIM BIOLOGICS INC Topic: NCATS
ABSTRACT Atrial fibrillationAFis the most common rhythm disturbance in the US and other developed countriesAF significantly affects the lives of the afflictedcausing symptoms that range from palpitations to fatigueweakness and activity intoleranceand substantially increasing the risks of strokecongestive heart failure and deathThe impact on public health is substantialwith more thanhospital admiss ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: PHOENIX PHARMALABS, INC. Topic: NIDA
Abstract Currentlyclinically used drug abuse medications exist for treatment of addiction to opiatesalcoholand nicotinebut not cocaineThe objective of the proposed project is to test the hypothesis that the partial kappa agonist PPLcan be effective as a pharmacotherapy for treatment of cocaine abuseBecause of chronic drug induced changes in the kappa opioid receptor systemkappa receptor directed c ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: NONINVASIX INC Topic: NICHD
AbstractIn newborn infants intermittent total hemoglobin concentrationTHbmeasurement represents an essential diagnostic testHoweverblood sampling in neonates results in iatrogenic anemiais a painful experience for infantsand is a tedious procedure for health care personnelBlood sampling forTHbmeasurements represents a high proportion of painful procedures required in infantsyet heel sticksthe most ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: LYST THERAPEUTICS LLC Topic: NHLBI
Project Description Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require surgical interventionComplications arising from the use of currently available prosthetic materials in the form of vascular graftspatchesor replaceme ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health