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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.
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SBC: LR TECHNOLOGIES, Inc. Topic: DHP17A001
In this topic, we plan to design a vital EMF sensor to work under any conditions. The sensor will be integrated with smart clothing and using e-textile materials.STTR Phase II 2018 Department of DefenseDefense Health Agency
SBC: UNVEIL LLC Topic: DHP17A003
Augmented reality (AR) offers the ability to enhance existing combat medic training by including perceptual cues and adaptive training elements to traditional simulation-based training using manikins. Unveil has developed a training system called the Macrocognitive AR Trainer (MART). MART is designed to foster the development of macrocognitive skills (e.g., sensemaking, assessment skills, mental m ...STTR Phase II 2018 Department of DefenseDefense Health Agency
SBC: Spectral Md, Inc. Topic: DHP17A006
The primary objective of this Phase II proposal is to construct and validate the portable SpectralMD DeepView imaging technology designed previously in Phase I. This device allows surgeons to quickly and objectively assess tissue viability in burn surgery prior to skin grafting. DeepView uses machine learning and multispectral imaging to generate quantitative prognostic images with easily interpre ...STTR Phase II 2018 Department of DefenseDefense Health Agency
SBC: ARCHIE MD INC. Topic: DHA17A002
Providing Army combat medics with meaningful experience in treatment of battlefield injuries is a particular challenge. Moulage has the potential to assist in acquiring what could otherwise be very hard-to-come-by preparatory experience for distressing real-life emergencies medics and soldiers may encounter in the field. However, current approaches to moulage are limited in their ability to reflec ...STTR Phase II 2018 Department of DefenseDefense Health Agency
Building an evidentiary case for circulating GHBP as a biomarker for drug-associated stunting of growthSBC: REVERAGEN BIOPHARMA, INC. Topic: NICHD
There is increasing interest in the use of biomarkers in clinical drug developmentwith much of thest Century Cures Act focused on encouraging this approachIdeallybiomarkers could provide and acute and objective read out of drug mechanism of actionpharmacodynamic biomarkersor prediction of later clinical benefit or harmsurrogate outcome measureHoweververy few biomarkers have been validated for rout ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Coactigon, Inc. Topic: 102
ABSTRACTSteroid Receptor CoactivatorSRCis a key breast cancer oncogene that is frequently overexpressed or amplified in estrogen receptorERand human epidermal growth factor receptorHERpositive breast cancersElevated expression of SRCalso has been associated with resistance to tamoxifen therapy and with poor disease outcome in HERpositive breast cancersNumerous studies have shown that experimental ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: Lacerta Therapeutics, Inc. Topic: 102
Abstract GlioblastomaGBMis the most lethal form of adult brain cancers with a median survival of andltmonths despite aggressive standard chemoradiationGBM are formed by GBM stem like cellsGSCsa major contributor to tumor recurrence and a natural focus for therapeutic developmentThere are two main reasons responsible for treatment failurehigh intraand inter tumor cellular and molecular heterogeneit ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: WEINBERG MEDICAL PHYSICS, INC. Topic: DHA18A001
There is an urgent need to bypass or cross the blood brain barrier (BBB) to deliver drugs for TBI treatment. This project aims to develop targted intranasally delivered, magnetically propulsed, and targted nanoparticles for traumatic brain injury (TBI). In Phase I, we will demonstrate the design, fabrication, and in vitro characterization of proposed drug laden magnetic nanoparticles as well as co ...STTR Phase I 2018 Department of DefenseDefense Health Agency
Development of a small molecule activator of integrin cell adhesion to enhance therapeutic responses to checkpoint blockade in cancerSBC: 7 Hills Pharma LLC Topic: 102
Recent FDA approvals of ipilimumabnivolumaband pembrolizumabwhich target checkpoint receptors cytotoxic T lymphocyte associated antigenCTLAand programmed deathPDhave ushered in a new era of cancer immunotherapy in metastatic melanomaDespite unprecedented overall survival benefits with combination therapythe incidence of complete responses are onlyimmune related adverse eventsirAEsare increasedand ...STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
SBC: IMMUNOBLUE, LLC Topic: NCI
PROJECT SUMMARY Melanoma is one of the most prevalent cancers and is estimated to account for overdeaths inin the United States aloneAlthough highly curable when detected earlytheyear survival rates decline precipitously for patients with regionaland metastaticmelanoma indicating a lack of efficacy of conventional therapiesand a strong need for novel therapies for this patient populationIn respons ...STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health